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《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:

24卷

期数:

2018年04期

页码:

344-347

栏目:

出版日期:

2018-07-20

文章信息/Info

Title:

Efficacy and safety of sublingual immunotherapy with dermatophagoides farinae drops for children with allergic rhinitis and asthma

作者:

刘梦昭; 刘长山

天津医科大学第二医院儿科，天津 300211

Author(s):

LIU Meng-zhao;  LIU Chang-shan

Department of Pediatrics, The Second Hospital, Tianjin Medical University, Tianjin 300211, China

关键词:

哮喘; 舌下免疫治疗; 粉尘螨滴剂; 儿童

Keywords:

bronchial asthma;  sublingual immunotherapy(SLIT);  dermatophagoides farinae;  children

分类号:

R725.6

DOI:

-

文献标志码:

Ａ

摘要:

目的：观察粉尘螨滴剂舌下免疫治疗哮喘伴过敏性鼻炎患儿的临床疗效及安全性。方法：观察分析接受粉尘螨滴剂舌下免疫治疗的哮喘伴过敏性鼻炎患儿72例，根据免疫治疗疗程分为1年组、2年组、3年组，随访评估治疗前后患儿哮喘症状（日间和夜间症状）评分、鼻炎症状评分、总症状评分（哮喘和鼻炎症状评分总和）、药物使用评分、哮喘和鼻炎的视觉模拟评分（VAS评分）。结果：1年组、2年组和3年组患儿治疗后哮喘症状评分、鼻炎症状评分、总症状评分、药物使用评分、哮喘和鼻炎的VAS评分较治疗前均显著下降（P＜0.05），治疗3年组和2年组药物使用评分显著低于1年组（P＜0.05），2年组和3年组之间药物使用评分未见显著差异。各治疗组未发现不良反应。结论：粉尘螨滴剂舌下免疫不同治疗组均具有较好的临床疗效且安全性好，治疗2年以上的患儿临床疗效更好。

Abstract:

Objective: To evaluate the efficacy and safety of sublingual immunotherapy (SLIT) with dermatophagoides farinae drops in children with allergic rhinitis and asthma. Methods: Seventy-two children with asthma and allergic rhinitis who recieved dermatophagoides farinae drops were assigned into 1-year group, 2-year group and 3-year group according to the course of SLIT. The asthma symptom scores (ASS, day and night), rhinitis symptom scores (RSS), total symptom scores (TSS, asthma and rhinitis symptom scores),medication scores (MS), and VAS scores of asthma and rhinitis were evaluated before and after SLIT. Results: There were significant differences in ASS, RSS, TSS, MS and VAS scores among children who underwent SLIT compared with baseline(P＜0.05). MS in 3-year group and 2-year group was significantly lower than that in 1-year group (P < 0.05). There were no significant differences in MS between 3-year group and 2-year group. Adverse reaction was not observed in each group. Conclusion: SLIT with dermatophagoides farinae drops is safe and effective in each SLIT group and has shown better efficacy after 2-year SLIT.

参考文献/References:

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备注/Memo

备注/Memo:

-

常用功能

更新日期/Last Update: 2018-07-20