|本期目录/Table of Contents|

[1]刘靓,王婷 综述,郑荣秀 审校.中枢性性早熟与KISS1、MKRN3系统的关系研究进展[J].天津医科大学学报,2018,24(03):274-277.
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中枢性性早熟与KISS1、MKRN3系统的关系研究进展(PDF)
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《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:
24卷
期数:
2018年03期
页码:
274-277
栏目:
综述
出版日期:
2018-05-20

文章信息/Info

Title:
-
作者:
刘靓; 王婷 综述; 郑荣秀 审校
天津医科大学总医院儿科，天津 300052
Author(s):
-
关键词:
中枢性性早熟; KISS1; MKRN3
Keywords:
-
分类号:
R725.8
DOI:
-
文献标志码:
A
摘要:
中枢性性早熟发病的具体机制至今仍不明确。近些年，科学家们发现一些基因的突变与HPG轴(下丘脑-垂体-性腺轴)提前激活有关。KISS1系统与MKRN3系统是近些年研究者们研究的热点。KISS1基因是一种肿瘤转移抑制基因，KISS1在HPG轴的上游发挥作用。MKRN3基因是一种母系印记基因，MKRN3在HPG轴下游发挥作用。有研究表明，KISS1系统的激活突变在HPG轴激活过程中起着重要的作用，MKRN3失活突变与中枢性性早熟密切相关。本文重点介绍了KISS1系统、MKRN3系统及中枢性性早熟与这两个系统的关系。
Abstract:
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相似文献/References:

[1]王昭冉,刘戈力,杨箐岩,等.促性腺激素及盆腔超声在中枢性性早熟女童诊断中的价值[J].天津医科大学学报,2018,24(01):32.
　WANG Zhao-ran,LIU Ge-li,YANG Qing-yan,et al.Value of gonadotropin and pelvic ultrasound in the diagnosis of central precocious puberty in girls[J].Journal of Tianjin Medical University,2018,24(03):32.

备注/Memo

备注/Memo:
文章编号 1006-8147(2018)03-0274-04
作者简介 刘靓（1991-），女，硕士在读，研究方向：小儿内分泌代谢性疾病；通信作者：郑荣秀，E-mail:rxzheng@hotmail.com。
更新日期/Last Update: 2018-05-20