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[1]李英,张学军.miR-93在多囊卵巢综合征患者血清中的表达及临床意义[J].天津医科大学学报,2018,24(03):209-211,215.
　LI Ying,ZHANG Xue-jun.Expression and clinical significance of miR-93 in the serum of patients with polycystic ovary syndrome[J].Journal of Tianjin Medical University,2018,24(03):209-211,215.
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miR-93在多囊卵巢综合征患者血清中的表达及临床意义(PDF)
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《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:
24卷
期数:
2018年03期
页码:
209-211,215
栏目:
出版日期:
2018-05-20

文章信息/Info

Title:
Expression and clinical significance of miR-93 in the serum of patients with polycystic ovary syndrome
作者:
李英1; 2; 张学军1
1.天津医科大学免疫学系， 天津 300070；2.天津市中心妇产科医院检验科，天津 300100
Author(s):
LI Ying1; 2; ZHANG Xue-jun1
1.Department of Immunology, Tianjin Medical University, Tianjin 300070，China; 2. Department of Clinical Laboratory; Tianjin Central Hospital of Gynecology and Obstetrics, Tianjin 300100，China
关键词:
多囊卵巢综合征; miR-93; 高雄激素血症; 胰岛素抵抗
Keywords:
polycystic ovary syndrome;  miR-93;  hyperandrogenemia;  insulin resistance
分类号:
R711.75
DOI:
-
文献标志码:
A
摘要:
目的：探讨miR-93在多囊卵巢综合征（PCOS）患者血清中的表达及临床意义。方法：利用实时荧光定量PCR分别检测PCOS患者（25例）和正常对照（25例）血清中miR-93的相对表达量，并分析miR-93与PCOS临床特征（高雄激素血症、胰岛素抵抗）的关系；绘制 ROC曲线评价血清miR-93诊断PCOS的价值。结果：与对照组相比，miR-93在PCOS患者血清中的相对表达量明显升高（Z =7.614，P < 0.01）；体质指数（BMI）、空腹血糖（FBG）、血清总睾酮（TT）和胰岛素抵抗指数（HOMA-IR）在PCOS患者中均升高（P < 0.05）。在对照组，血清miR-93的水平与TT、HOMA-IR的相关系数r值分别为0.03、0.39（均P > 0.05）；在PCOS组，血清miR-93的水平与TT、HOMA-IR的相关系数r值分别为0.33、0.28（均P > 0.05）。ROC曲线分析显示，血清miR-93用于诊断PCOS的曲线下面积为0.73，敏感度为70%，特异度为78%。结论：miR-93在PCOS患者血清中表达上调，可能与PCOS的发生发展相关，且用于诊断PCOS具有一定的价值。
Abstract:
Objective: To investigate the expression and clinical significance of serum miR-93 in patients with polycystic ovary syndrome (PCOS). Methods: The relative expression level of serum miR-93 was detected in PCOS group(n=25) and control group(n=25) by quantitative real time PCR, and the relationship between miR-93 and clinical features of PCOS (hyperandrogenemia and insulin resistance) were analyzed. Furthermore, the value of serum miR-93 was evaluated in the diagnosis of PCOS using ROC curve. Results: Compared with the control group, the relative levels of serum miR-93 in PCOS patients were significantly increased (Z =7.614, P < 0.01), and body mass index (BMI), fasting blood-glucose (FBG), serum total testosterone (TT) and insulin resistance index were elevated in PCOS patients (P < 0.05). In control group, correlation coefficient r values of serum miR-93 with TT and HOMA-IR were 0.03 and 0.39(both P > 0.05), respectively. In PCOS group, correlation coefficient r values of serum miR-93 with TT and HOMA-IR were 0.33 and 0.28 (both P > 0.05), respectively. ROC curve analysis showed that the area under the curve, sensitivity and specificity of serum miR-93 for the diagnosis of PCOS were 0.73, 70%, and 78%, respectively. Conclusion: The expression levels of miR-93 in PCOS patients are up-regulated, therefore the increment of miR-93 may be associated with the occurrence and development of PCOS, and it has certain value for the diagnosis of PCOS.

参考文献/References:

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备注/Memo

备注/Memo:
文章编号 1006-8147(2018)03-0209-03
基金项目 天津市卫生局科技基金资助项目（2013KY39）
作者简介 李英（1987-），女，初级检验技师，硕士在读，研究方向：妇科疾病；通信作者：张学军，E-mail: xjzh@tmu.edu.cn。
更新日期/Last Update: 2018-05-20