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《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:

23卷

期数:

2017年05期

页码:

419-422

栏目:

临床医学

出版日期:

2017-09-20

文章信息/Info

Title:

Relations of IR to LEP, APN and FGF-21 among children with different BMIs

文章编号:

1006-8147(2017)05-0419-04

作者:

胡 楠¹; 刘 艳²; 李素芬²; 金娜娜² ; 高鹏飞² ; 何庆¹

(1.天津医科大学总医院内分泌代谢科,天津 300052; 2.天津海滨人民医院内分泌科, 天津 300280)

Author(s):

HU Nan¹;  LIU Yan²;  LI Su-fen²;  JIN Na-na²;  GAO Peng-fei² ; He Qing¹

（1.Department of Endocrinology and Metabolism ,General Hospital, Tianjin Medical University ，Tianjin 300052，China；2. Department of Endocrinology, Coastal People’s Hospital of Tianjin, Tianjin 300280 ,China）

关键词:

体质指数; 瘦素; 脂联素; FGF-21; 胰岛素抵抗; 儿童青少年

Keywords:

BMI' target="_blank" rel="external">">BMI;  LEP;  APN; FGF-21; insulin resistance;  children

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分类号:

R589.2

DOI:

-

文献标志码:

A

摘要:

目的：探究不同体质指数（BMI）儿童青少年脂肪炎性因子瘦素（LEP）、脂联素（APN）、人成纤维细胞生长因子-21(FGF-21)与胰岛素抵抗（IR）的相关性。方法：收集7～16岁12 476例儿童青少年体检资料，根据BMI分为肥胖、超重及正常组；选取30例志愿者为研究对象，检验空腹血糖、胰岛素和血清LEP、APN、FGF-21等，计算胰岛素抵抗指数（HOMA-IR）并分析LEP、APN、FGF-21与之的相关性。结果：与正常组相比，两组LEP明显升高，肥胖组HOMA-IR、FGF-21明显升高，APN明显降低；与超重组相比，肥胖组HOMA-IR、LEP与FGF-21明显升高（P<0.05）。Pearson相关分析提示HOMA-IR与LEP、FGF-21呈正相关(r=0.563、0.301；P<0.05）；与ANP呈负相关（r=-0.376；P<0.001）。结论：儿童青少年肥胖易产生胰岛素抵抗，可能与脂肪组织分泌脂肪炎性因子有关，检测血清LEP、APN、FGF-21可以为预测胰岛素抵抗提供参考。

Abstract:

Objectives: To explore the relations of IR to the levels of leptin (LEP), adiponectin (APN) and fibroblastic growth factor-21 ( FGF-21) among children with different BMIs. Methods: The physical reports of 12 476 children from 7 to 16 years old were selected. According to BMI, overweight group, obesity group and normal group were set as test groups, with 30 volunteers being selected as study subjects to each group respectively. The fasting blood-glucose, insulin and serum LEP, APN AND FGF-21 of these study subjects were tested to figure out HOMA-IR and its relations to LEP, APN, FGF-21. Results: Compared with normal group, the levels of LEP were significantly higher in both overweight and obesity group, and the levels of HOMA-IR and FGF-21 in obesity group increased significantly, but its levels of APN decreased sharply; Compared with overweight group, the levels of HOMA-IR, LEP and FGF-21 among obesity group increased markedly (P﹤0.05). Pearson correlation analysis showed that HOMA-IR was positively associated with LEP and FGF-21 (r=0.563, 0.301; P﹤0.05), but was negatively correlated with APN level (r=-0.376;P﹤0.001). Conclusion: Children obesity can lead to IR, which may result from adipose tissue secreting inflammatory cytokines. Test serum LEP, APN and FGF-21 can provide reference for prognosing IR.

参考文献/References:

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备注/Memo

备注/Memo:

基金项目 国家自然科学基金资助项目（81570144，81270144）；滨海新区卫生局科技项目（2014BWKZ004）

作者简介 胡楠（1989-），女，硕士在读，研究方向：内分泌与代谢病;

通信作者：何庆，E-mail：hech69@163.com。

常用功能

更新日期/Last Update: 2017-09-20