|本期目录/Table of Contents|

[1]李 江,王 刚.性激素结合球蛋白在多囊卵巢综合征患者中的变化及与其他指标的关系[J].天津医科大学学报,2016,22(04):325-327.
　LI Jiang,WANG Gang.Changes of SHBG in patients with polycystic ovary syndrome and their relationship with other indicators[J].Journal of Tianjin Medical University,2016,22(04):325-327.
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性激素结合球蛋白在多囊卵巢综合征患者中的变化及与其他指标的关系(PDF)
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《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:
22卷
期数:
2016年04期
页码:
325-327
栏目:
临床医学
出版日期:
2016-07-19

文章信息/Info

Title:
Changes of SHBG in patients with polycystic ovary syndrome and their relationship with other indicators
文章编号:
1006-8147（2016）04-0325-03
作者:
李 江 ;  王 刚
(天津医科大学总医院医学检验科，天津300052）
Author(s):
LI Jiang ; WANG Gang
（?Department of Laboratory, Tianjin Medical University General Hospital, Tianjin 300052, China.）
关键词:
性激素结合球蛋白; 多囊卵巢综合征; 相关性
Keywords:
sex hormone binding globulin;  polycystic ovary syndrome ;  correlation
分类号:
R711.75
DOI:
-
文献标志码:
A
摘要:

目的： 探讨性激素结合球蛋白（SHBG）在多囊卵巢综合征（PCOS）患者血清中的变化及与其他内分泌指标的关系。方法： 选择58例PCOS患者分为PCOS-IR组30例、PCOS-NIR组28例，30例健康育龄期妇女为对照组。比较PCOS-IR组、PCOS-NIR组患者SHBG、空腹血糖（FPG）、空腹胰岛素（FINS）、睾酮（T）、雌二醇（E2）、泌乳素（PRL）、卵泡刺激素（FSH）、黄体生成素（LH）水平以及HOMA-IR、LH/FSH、FTI的值与对照组的差异，并用Spearman相关分析法分别分析SHBG与其他指标的相关性。结果：PCOS-IR组及PCOS-NIR组患者的SHBG、FINS、HOMA-IR、 LH、T、LH/FSH及FTI与对照组比较差异有统计学意义（P<0.01）；PCOS-IR组及PCOS-NIR组患者的FPG与对照组比较无统计学意义（P>0.05）。PCOS-IR组与PCOS-NIR组患者相比SHBG、FINS、HOMA-IR及FTI差异有统计学意义（P<0.01），PCOS-IR组与PCOS-NIR组患者相比各项性激素指标比较无统计学意义（P>0.05）。SHBG与FINS、T、FTI、HOMA-IR呈负相关(r值分别为: -0.519、-0.513、-0.592、-0.588，均P<0.01)，而SHBG与FPG、LH/FSH(r=-0.292，P>0.05)、LH/FSH(r=-0.124，P>0.05)并无相关性。结论： PCOS患者与对照组相比SHBG降低，FINS、T、FTI、HOMA-IR、LH、LH/FSH升高；且SHBG与FINS、T、FTI、HOMA-IR呈负相关，提示低水平SHBG是预防和治疗PCOS的重要实验指标。

Abstract:
Objective ： To investigate the changes of serum sex hormone binding globulin （SHBG ）and its correlation with other endocrine parameters in patients with polycystic ovary syndrome (PCOS). Methods: Fifty-eight patients with PCOS were selected and divided into PCOS-IR group 30 cases, PCOS-NIR group 28 cases and 30 cases of healthy women as control group. The levels of SHBG, FPG, FINS, T, E2, PRL, FSH, LH in serum and the value of HOMA-IR and LH/FSH were compared between PCOS-IR, PCOS-NIR and normal control, the correlation between SHBG and FPG, FINS, T, HOMA-IR, LH/FSH were analyzed by Spearman correlation. Results: The levels of serum SHBG, FINS, T, FTI, LH and the value of HOMA-IR, LH/FSH and FTI for the PCOS-IR group and PCOS-NIR group had significant difference from those for the control group(P all<0.01). Levels of serum FPG, E2, PRL, FSH were not higher in the PCOS-IR group and PCOS-NIR group than that in the control group (P>0.05). The levels of SHBG, FINS, HOMA-IR and FTI for the PCOS-IR group had significant difference from those for the PCOS-NIR group (P all<0.01). Compared with the PCOS-NIR group, all sex hormone indexes of PCOS-IR group had no statistical significance (P>0.05). There were negative correlations between SHBG and FINS, T, FTI and HOMA-IR in the PCOS group(r=-0.519，-0.513，0.592，-0.588，P all<0.01). But there was no correlation between SHBG and FPG, LH/FSH(r=-0.292，-0.124，P all>0.05). Conclusion: Patients who have diagnosed with PCOS show lower level of serum SHBG and higher levels of FINS, T, FTI, HOMA-IR, LH, LH/FSH than the control group. SHBG may have negative correlation with FINS, T, FTI and HOMA-IR in the PCOS group. The low level of SHBG may be an important experiment basis to predict and treat PCOS.

参考文献/References:

[1]Vrbíková J. Poly cystic ovary syndrome[J]. Vnitr Lek, 2015, 61(10): 886

[2]March W A, Moore V M, Willson K J, et al. The prevalence of polycystic ovary syndrome in a community sample assaaaed under contrasting diagnostic criteria[J]. Hum Reprod, 2010, 25(2): 544

[3]Li R, Yu G, Yang D, et al. Prevalence and predictors of metabolic abnormalities in Chinese women with PCOS:a cross-sectional study[Z], 2014: 76

[4]李央，林金芳．多囊卵巢综合征患者性激素结合球蛋白和总睾酮与胰岛素抵抗的相关性[J]．中华糖尿病杂志，2009，1（6）：422

[5]Lee D E, Park S Y, Park S Y, et al. Clinical and biochemical profiles according to homeostasis model assessment-insulin resistance(HOMA-IR)in korean women with polycystic ovary syndrome[J]. J Menopausal Med, 2014, 20(3): 104

[6]Rotterdam ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group. Reviser 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome[J]. Fertil Steril, 2004, 81(1): 19

[7]Muscogiuri G, Colao A, Orio F. Insulin-Mediated diseases: adrenal mass and polycystic ovary syncrome[J]. Trends in Endocrinology and Metabolism, 2015, 26(10): 512

[8]Cikim A S, Ozbey N, Sencer E, et al. Associations among sex hormone binding globulin concentrations and characteristics of the metabolic syndrome in obese women[J]. Diabetes Nutr Metab, 2004, 17(5): 290

[9]乐明山，杨俊丽．腰臀比和体质量指数与代谢综合征患病关系的临床研究[J]．检验医学与临床，2013，10（23）：3167

[10]Lin X F，Wu R R，Du J， et al. Exploring the significance of sex hormone-binding globulin examination in the treament of women with polycystic ovarian syndrome (PCOS)[J]. Clin Exp Obstet Gynecol， 2015，42(3):315

[11]周斌，王薇薇，张文辉，等．多囊卵巢综合征患者性激素结合球蛋白和硫酸脱氢表雄酮的相关性分析[J]．中国实验诊断学，2007，11（6）：763

[12]Maliqueo M, Bacallao K, Quezada S, et al. Sex hormone-binding globulin expression in the endometria of women with polycystic ovary syndrome[J]. Fertil Steril, 2007, 87(2): 321

[13]Fan Wei, Li Shangwei, Chen Qiong, et al. Association between the (TAAAA)n SHBG polymorphism and PCOS: a systematic review and meta-analysis[J]. Gynecol Endocrinol, 2013, 29(7): 645

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备注/Memo

备注/Memo:

作者简介 李江（1972-），男，主管技师，大本，研究方向：免疫学检验，E-mail：lianggeren2000@sohu.com。



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更新日期/Last Update: 2016-07-13