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[1]郑元培,傅胜惠,高 姗,等.血液透析患者单纯性结膜下出血相关影响因素研究[J].天津医科大学学报,2016,22(02):157-159.
　ZHENG Yuan-pei,FU Sheng-hui,GAO Shan,et al.Relationship between spontaneous subcoujunctival hemorrhage and arterial stiffness in hemodialysis patients[J].Journal of Tianjin Medical University,2016,22(02):157-159.
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血液透析患者单纯性结膜下出血相关影响因素研究(PDF)
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《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:
22卷
期数:
2016年02期
页码:
157-159
栏目:
临床医学
出版日期:
2016-03-20

文章信息/Info

Title:
Relationship between spontaneous subcoujunctival hemorrhage and arterial stiffness in hemodialysis patients
文章编号:
1006-8147（2016）02-0157-03
作者:
?郑元培1 ; 傅胜惠2 ; 高 姗2 ; 闫铁昆2 ; 赵少贞1

（1.天津医科大学眼科医院屈光与角膜病科，天津 300384；2.天津医科大学总医院肾内科，天津 300052）

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Author(s):
ZHENG Yuan-pei1;  FU Sheng-hui2;  GAO Shan2;  YAN Tie-kun2;  ZHAO Shao-zhen1

（1.Department of Refractive and Corneal Disease, Eye Hospital, Tianjin Medical University, Tianjin, 300384 China; 2.Department of Nephrology, General Hospital, Tianjin Medical University, Tianjin 300052, China）

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关键词:
尿毒症;  血液透析;  动脉僵硬度;  单纯性结膜下出血;  高血压
Keywords:
uremia;  hemodialysis;  arterial stiffness;  spontaneous subcoujunctival hemorrhage;  hypertension
分类号:
R777.39
DOI:
-
文献标志码:
A
摘要:
目的： 探讨尿毒症血液透析患者单纯性结膜下出血相关影响因素。方法： 观察310例行维持性血液透析治疗的尿毒症患者，根据观察期内是否新发单纯性结膜下出血，分为出血组与未出血组。记录患者临床资料及血生化检查指标。两组均行踝臂脉搏波传导速度(baPWV)检测。分析各组间临床及生化指标、baPWV的差异，探讨影响单纯性结膜下出血的危险因素。结果： 310例尿毒症血液透析患者中，观察期内新发单纯性结膜下出血30例次。出血组患者透析龄、血压、既往单纯性结膜下出血病史、血磷、iPTH水平均明显高于未出血组，差异有统计学意义(均P<0.05)，但肝素用量、血肌酐、TC、TG、CRP水平无明显差异(均P>0.05)。baPWV检测结果显示，出血组患者baPWV为（20.4±3.1）m/s，明显大于未出血组（14.2±3.6）m/s，差异有统计学意义(P<0.01)。多因素回归分析显示，既往单纯性结膜下出血病史、血压、baPWV水平是新发单纯性结膜下出血的独立危险因素。结论：单纯性结膜下出血病史、血压、baPWV可能是导致尿毒症血液透析患者单纯性结膜下出血的重要原因。
Abstract:
Objective ： To investigate the relationship between spontaneous subcoujunctival hemorrhage and arterial stiffness in uremic patients under maintained hemodialysis. Methods： Three hundred and ten maintained hemodialysis patients from January 2013 to December 2013 were involved and divided into hemorrhage group and non-hemorrhage group based on whether spontaneous sub-conjunctival hemorrhage occurred in the period. Clinical data and blood biochemical indexes were collected. Twenty healthy people served as the control group. The ankle-brachial pulse wave velocity (baPWV) was measured in all subjects. Results： There were 310 cases being enrolled in at the beginning and 30 cases with spontaneous subconjunctival hemorrhage in the observation period. The age, dialysis history, diabetes, hypertension, previous history of subconjunctival hemorrhage, serum phosphorus and iPTH were significantly higher in hemorrhage group than in non- hemorrhage group (all P <0.05). However, the doses of unfractionated heparin, serum creatinine, TC, TG, and CRP were not significantly different between the two groups (all P > 0.05). The values of baPWV in hemorrhage group was （20.4 ± 3.1） m/s, significantly higher than in non-hemorrhage group[ (14.2 ± 3.6) m/s] and in the control group [(11.2±2.2) m/s] ( all P <0.01). Multivariate regression analysis showed that the previous history of subconjunctival hemorrhage, hypertension, diabetes and baPWV were independent risk factors for spontaneous subconjunctival hemorrhage. Conclusion ：The history of spontaneous subconjunctival hemorrhage, blood pressure, and baPWV may be important causes of spontaneous subconjunctival hemorrhage in patients under hemodialysis.

参考文献/References:

[1]Hu D N,Mou C H,Chao S C, et al.Incidence of Non-Traumatic subconjunctival hemorrhage in a nationwide study in Taiwan from 2000 to 2011[J].PLoS One,2015,10(7):e0132762.
[2]Mimura T,Yamagami S,Usui T, et al.Location and extent of subconjunctival hemorrhage[J].Ophthalmologica,2010,224(2):90.
[3]Harada K,Fujimoto T,Asato Y, et al.Virological and epidemiological analysis of coxsackievirus A24 variant epidemic of acute hemorrhagic conjunctivitis in Okinawa, Japan, in 2011[J].Clin Ophthalmol,2015,9(9):1085.
[4]王婷婷.不同制瓣方式LASIK术后玻璃体后脱离与结膜下出血的研究[D].天津:天津医科大学,2013
[5]闫铁昆,林珊,贾俊亚,等.尿毒症患者桡动脉钙化与骨密度及血清骨代谢指标的关系[J].中华肾脏病杂志,2012,28(12):916
[6]Simpson H K,Baird J,Allison M, et al.Long-term use of the low molecular weight heparin tinzaparin in haemodialysis[J].Haemostasis,1997,26(2):90

相似文献/References:

[1]李可,刘娟娟,刘辉,等.治疗尿毒症新型血液灌流吸附剂体外实验研究[J].天津医科大学学报,2021,27(03):291.
　LI Ke,LIU Juan-juan,LIU Hui,et al.In vitro experimental study on a new hemoperfusionadsorbent to cure uremia[J].Journal of Tianjin Medical University,2021,27(02):291.

备注/Memo

备注/Memo:

作者简介 郑元培（1986-），男，硕士在读，研究方向：眼视光学；通信作者：赵少贞，E-mail:zhaosz1997@sina.com。



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更新日期/Last Update: 2016-03-23