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《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:

22卷

期数:

2016年02期

页码:

101-103

栏目:

专题报道

出版日期:

2016-03-20

文章信息/Info

Title:

Value of vWF and?D-dimer for thrombosis and prognosis in patients with non-valvular atrial fibrillation

文章编号:

1006-8147（2016）02-0101-03

作者:

张彦月¹; 林文华²

(1.天津医科大学研究生院, 天津 300070;2.泰达国际心血管病医院内一科,天津 300145)

Author(s):

ZHANG Yan-yue¹ ; LIN Wen-hua²

?

(1.Department of Graduate School ,Tianjin Medical University.Tianjin 300070,China; 2. Department of Cardiology, TEDA International Cardiovascular Hospital, Tianjin 300145, China)

关键词:

心房颤动;  血栓;  血管性血友病因子;  D-二聚体

Keywords:

atrial fibrillation ;  thrombosis;  von Willebrand factor;  D-dime

分类号:

R541

DOI:

-

文献标志码:

A

摘要:

目的：研究心房颤动(AF)患者血浆血管性血友病因子（vWF）因子及D-二聚体水平在血栓形成及临床预后中的价值。方法：选取具有完整资料确诊AF患者61例，无AF史30例做为对照组，根据食道超声(TEE)及有无血栓史将AF患者分为血栓组（n=13)及非血栓组(n=48)，测定D-二聚体及vWF含量，并评价血栓组行抗凝治疗后3个月的血栓情况，将其分为血栓溶解组（n=9)及血栓未溶解组(n=4)，复测各组的两因子水平，进行分析评价。结果：与对照组比较，血栓组与非血栓组vWF水平及D-二聚体水平均高于窦性心律组，P<0.05。血栓组vWF水平及D-二聚体水平高非血栓组，P<0.05。血栓组经治疗后血栓溶解组两因子水平较治疗前明显下降（P<0.05),而血栓未溶解组两因子水平也较治疗前下降，但无统计学意义（P>0.05).且房颤血栓组血浆D-二聚体及vWF水平呈正相关性（r=0.952, P<0.05)。结论：vWF因子及D-二聚体水平可用于评估AF患者血栓形成风险的高低，同时可以预测合并血栓的AF患者的临床预后。

Abstract:

?Objective: To study the value of von Willebrand factor（vWF）and plasma D-dimer in patients with non-valvular atrial fibrillation (AF) for thrombosis and prognosis . Methods: Sixty-one patients with AF and thirty patients with non-AF were enrolled into the study, patients with AF according to transesophageal echocardiography (TEE) and history of thrombosis were divided into two groups, thrombus group(n=13) and non-thrombus group (n=48), then the plasma concentration of vWF and D-dimer were measured. Furthermore, thrombus group was divided into thrombolysis group and non-thrombolysis group through anticoagulant treatment, after anlysing and evaluating the results. Results: Compared with the control group, the palsma levels of vWF and D-dimer were all significantly higher (P<0.05) in patients in thrombus group and non-thrombus group. Compared with thrombus group, the levels of vWF and D-dimer were higher in patients of non-thrombus group. The levels of the two factors were significantly lower in thrombolysis group compared with prior treatment, but in non-thrombolysis group they showed no statistical significance before and after the treatment. In addition, vWF was positively correlated with D-dimer(r=0.952, P<0.05). Conclusion: The level of vWF and D-dimer could estimate the risk of thrombus formation in AF patients, as well as make good prognosis.

参考文献/References:

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备注/Memo

备注/Memo:

作者简介 张彦月 (1988- ),女,硕士在读，研究方向：心血管专业；通信作者： 林文华， E-mail:linwernhua@sina.com。

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更新日期/Last Update: 2016-03-23