|本期目录/Table of Contents|

[1]陈延勋,李广平. 非瓣膜性心房颤动患者尿酸与CHADS2、CHA2DS2-VASc评分的关系[J].天津医科大学学报,2015,21(03):185-188.
 CHEN Yan-xun,LI Guang-ping. Relationship between uric acid and CHADS2/CHA2DS2-VASc Score in patients with nonvalvular atrial fibrillation[J].Journal of Tianjin Medical University,2015,21(03):185-188.
点击复制

 非瓣膜性心房颤动患者尿酸与CHADS2、CHADS-VASc评分的关系(PDF)
分享到:

《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:
21卷
期数:
2015年03期
页码:
185-188
栏目:
专题报道
出版日期:
2015-05-20

文章信息/Info

Title:
 Relationship between uric acid and CHADS2/CHA2DS2-VASc Score in patients with nonvalvular atrial fibrillation
文章编号:
1006-8147(2015)03-0185-04
作者:
 陈延勋 李广平

 
 (天津医科大学第二医院心脏科, 天津 300211)
Author(s):
 CHEN Yan-xun LI Guang-ping
 (Department of Cardiology,The Second Hospital ,Tianjin Medical University ,Tianjin 300211,China)
关键词:
 心房颤动 尿酸 CHADS2 CHA2DS2-VASc
Keywords:
 atrial fibrillation uric acid CHADS2CHA2DS2-VASc
分类号:
R541.7+5
DOI:
-
文献标志码:
A
摘要:
 目的:探讨非瓣膜性心房颤动(房颤)患者尿酸(UA)与评估房颤患者血栓栓塞风险的CHADS2、CHA2DS2-VAS c评分的关系。方法:连续入选非瓣膜性房颤188例,对患者进行CHADS2和CHA2DS2-VASc评分,同时记录年龄、性别、伴发疾病、实验室指标、超声心动图结果等。根据CHADS2、CHA2DS2-VASc评分将房颤发生血栓栓塞的风险分为低中危和高危组,比较房颤患者发生血栓风险低中危组与高危组各项指标的差异,同时探讨房颤患者UA与CHADS2和CHA2DS2-VASc评分之间的关系。结果:无论何种分组方式,两组间年龄、高血压史、糖尿病史、冠心病史、脑卒中有统计学差异(P<0.05),与低中危组相比,高危组年龄增加,UA、左房内径(LAD)、左室舒张末内径(LVEDD)增加,左室射血分数(LVEF)下降(P<0.05)。相关分析显示,尿酸、LAD、LVEDD和CHADS2、CHA2DS2-VADSc评分呈正相关,LVEF和CHADS2、CHA2DS2-VADSc评分呈负相关。结论:非瓣膜性房颤患者UA与CHADS2、CHA2DS2-VASc评分呈正相关。
Abstract:
 Objective: To investigate the relationship between uric acid (UA) and CHADS2,CHA2DS2-VASc score for the evaluation of thromboembolism risk in patients with non-valvular atrial fibrillation(AF). Methods: One hundred and eighty-eight patients with nonvalvular Af(69 with paroxysmal Af and 119 with persistent AF) were collected in this study. The baseline clinical data were detected including age, sex, comorbidties, laboratory parameters and ecocardiography. CHADS2 and CHA2DS2-VASc risk scores for each patient were calculated. According to CHADS2 and CHA2DS2-VASc scores, the Af patients were divided into low-intermediate group and high risk group respectively, and the parameters between the two groups were compared ,andthe relationship between UA with AF evaluated. Results:The base characteristics between two groups had significant differences in age and comorbidities, in all groups method. Group with higher CHADS2 and CHA2DS2-VASc scores had older age ,higher UA, left atrial diameter(LAD) ,left ventricular end-diastolic diameter(LVEDD) and lower left ventricular ejection fraction(LVEF). The correlation analysis showed UA,LVEDD,LAD and CHADS2,CHA2DS2-VASc score were positively correlated,however LVEF and CHADS2,CHA2DS2-VASc score were negatively correlated. Conclusion: UA is significantly correlated with CHADS2 and CHA2DS2-VASc scores in patients with AF.

参考文献/References:

[1]European Heart Rhythm Association, European Association for Cardio-Thoracic Surgery, Camm A J, et al. Guidelines for the management of atrial fibrillation: the Task Force for the Management of Atrial Fibrillation of the European Society of Cardiology (ESC)[J]. Eur Heart J, 2010, 31(19): 2369

[2] Shankar A, Klein R, Klein B E, et al. The association between serum uric acid level and long-term incidence of hypertension:population-based cohort study[J]. J Hum Hypertens, 2006, 20(12): 937

[3] Fang J, Alderman M H. Serum uric acid and cardiovascular mortality:the NHANES I epidemio-

logic follow-up study,1971-1992,National Health and Nutrition Examination Survey[J].JAMA,

2000,283(18):2404

[4]Chonchol M, Shlipak M G, Katz R, et al. Relationship of uric acid with progression of kidney disease[J]. Am J Kidney Dis, 2007, 50(2): 239

[5]A Shankar B E, R Klein E A. Association between serum uric acid level and peripheral arterial disease[J]. Atherosclerosis, 2008, 196(2): 749

[6]Yoo Tae WOO, Sung K C, Shin H S, et al. Relationship between serum uric acid concentration and insulin resistance and metabolic syndrome[J]. Circ J, 2005, 69(8): 928

[7]Chao T F, Hung C L, Chen S J, et al. The association between hyperuricemia,left atrialsize and new-onset atrial fibrillation[J]. Int J Cardiol, 2013, 168(4): 4027

[8]Tamariz L, Agarwal S, Soliman E Z ,et al. Association of serum uric acid with incidentatrial fibr-

rillation[J]. AM J Cardiol, 2011,108(9):1272

[9]Go A S, Hylek E M, Phillips K A, et al. Prevalence of diagnosed atrial fibrillation in adults: National implications for rhythm management and stroke prevention: the AnTicoagulation and Risk Factors in Atrial Fibrillation (ATRIA) Study[J]. JAMA, 2001, 285(18): 2370

[10]Taillandier S, Olesen J B, Clémenty N, et al. Prognosis in patients with atrial fibrillation and CHA2DS2-VASc Score = 0 in a community-based cohort study[J]. J Cardiovasc Electrophysiol, 2012, 23(7): 708

[11]Numa S, Hirai T. Hyperuricemia and transesophageal echocardiogra-phic thromboembolic risk in patients with atrial fibrillation at clinically low-intermediate risk[J]. Circulation Journal, 2014, 78(7): 1600

[12]Su H M, Lin T H, Hsu P C, et al. Association of hyperuricemia with cardiac events in patients with atrial fibrillation[J]. Int J Cardiol, 2014, 172(2): 464

[13]Kaufman M,Guglin M . Uric acid in heart failure:a biomarker or therapeutic target[J]. Heart Fail Rev, 2013, 18(2): 177

[14]Mazzali M, Kanellis J, Han Lin, et al. Hyperuricemia induces a primary renal arteriolopathy in rats by a blood pressure-independent mechanism[J]. Am J Physiol Renal Physiol, 2002, 282(6): F991

[15]Palmer T M, Nordestgaard B G, Benn M, et al. Association of plasma uric acidwith ischaemic heart disease and blood pressure:mendelian randomisationanalysis of two large cohorts[J]. BMJ, 2013, 347: 4262

[16]Høieggen A, Alderman M H, Kjeldsen S E, et al. The impact of serum uric acid on cardiovascular outcomes in the Life study[J]. Kidney Int, 2004, 65(3): 1041

[17]Bandaru P, Shankar A. Association between serum uric acid levels and diabetes mellitus[J]. Int J Endocrinol, 2011, 2011: 604715

相似文献/References:

[1]张 茜,李洪发,刘俊玲,等. 快速扩弓后牙齿及牙槽骨变化的锥体束CT研究[J].天津医科大学学报,2014,20(01):57.
 ZHANG Qian,LI Hong- fa,LIU Jun-ling,et al. Study on cone beam computed tomography study of tooth and alveolar bone changes after rapid maxillary expansion treatment [J].Journal of Tianjin Medical University,2014,20(03):57.
[2]马长辉,杨万松.血清丙氨酸转氨酶与ST段抬高型心肌梗死的相关性研究[J].天津医科大学学报,2014,20(02):116.
 MA Chang-hui,YANG Wan-song.Clinical study of serum alanine aminotransferase in patients with acute ST-segment elevation myocardial infarction[J].Journal of Tianjin Medical University,2014,20(03):116.
[3]李 颖 综述,夏 天 审校. 肥胖相关性肾病的研究进展[J].天津医科大学学报,2014,20(02):165.
[4]牛 健,于晓旭,李 雪,等.重组 CARDs TX 融合蛋白的表达纯化与复性[J].天津医科大学学报,2014,20(03):184.
 NIU Jian,YU Xiao-xu,LI Xue,et al.Expression, purification and renaturation of recombinant CARDs TX fusion protein[J].Journal of Tianjin Medical University,2014,20(03):184.
[5]陈清刚,钱 明,王 毅,等.首发精神分裂症患者与超高危人群认知功能的对照研究[J].天津医科大学学报,2014,20(03):216.
 CHEN Qing gang,QIAN Ming,WANG Yi,et al.Control study of cognitive function in ultra-high risk population of schizophrenia and first-episode schizophrenia patients[J].Journal of Tianjin Medical University,2014,20(03):216.
[6]单立新,高 越,王学菊.血清Cys C、RBP、尿mALb/ Cr检测在糖尿病肾病早期诊断中的价值[J].天津医科大学学报,2014,20(03):241.
[7]班新超,孙保存,谷彦军,等. CXCR4和CathepsinD在恶性纤维组织细胞瘤中的表达及意义[J].天津医科大学学报,2014,20(04):264.
 BAN Xin-chao,SUN Bao-cun,GU Yan-jun,et al.Expression of CXCR4 and CathepsinD in malignant fibrous histiocytoma and their biological significance[J].Journal of Tianjin Medical University,2014,20(03):264.
[8]谭艳萍,吴校伟,刘 寅,等. 冠心病合并糖尿病患者药物涂层支架术后观察[J].天津医科大学学报,2014,20(05):414.
[9]叶剑飞 综述. microRNAs与肿瘤研究的新进展[J].天津医科大学学报,2014,20(05):416.
[10]李 姗,严海泓,章 萍,等. 长春新碱致双手麻木与麻痹性肠梗阻1例报道[J].天津医科大学学报,2014,20(05):373.

备注/Memo

备注/Memo:
 作者简 陈延勋(1988-),男,硕士在读,研究方向:心血管内科;通信作者:李广平,E-mail:tjcardiol@126.com 。

更新日期/Last Update: 2015-05-26