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《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:

22卷

期数:

2016年02期

页码:

97-100

栏目:

专题报道

出版日期:

2016-03-20

文章信息/Info

Title:

Effect of trimetazidine on myocardial injury in patients with unstable angina pectoris underwent undergoing percutaneous coronary intervention

文章编号:

1006-8147（2016）02-0097-04

作者:

邵 帅¹; 李广平¹; 石昭昭²; 倪艳萍¹; 刘红梅¹

(1．天津医科大学第二医院心脏科,天津心脏病学研究所,天津 300211; 2.陕西省西安市第一医院心内科,西安 710002)

Author(s):

SHAO Shuai¹;  LI Guang-ping¹;  SHI Zhao-zhao²;  NI Yan-ping¹;  LIU Hong-mei¹

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(1.Department of Cardiology, The Second Hospital, Tianjin Medical University, Tianjin Institute of Cardiology,Tianjin 300211, China; 2.Xi^, An Number One Hospital, Xi^,an 710002, China)

关键词:

美他嗪; 不稳定性心绞痛; 经皮冠状动脉介入治疗; 心肌损伤

Keywords:

trimetazidinen;  unstable angina pectoris;  percutaneous coronary intervention;  myocardial injure

分类号:

R541.4

DOI:

-

文献标志码:

A

摘要:

?目的：观察不稳定性心绞痛（UAP）患者经皮冠状动脉介入（PCI）治疗前后心肌损伤标记物血清肌酸激酶同工酶（CK-MB）、血浆肌钙蛋白I（cTnI）及心脏型脂肪酸结合蛋白（h-FABP）的水平变化，评价曲美他嗪对CK-MB、cTnI及h-FABP的影响。方法：将98例UAP患者随机分为曲美他嗪组（37例）及对照组（61例），于PCI术前即刻及术后次日清晨6时分别检测血清CK-MB、cTnI及h-FABP，另选取对照组加测术前即刻、术后3 h、6 h及术后>10h的血清h-FABP水平。结果：对照组术后CK-MB及cTnI含量较同组术前明显增高（P<0.05），曲美他嗪组术后CK-MB及cTnI含量较同组术前有所增高（P>0.05），对照组和曲美他嗪组术后>10h测得h-FABP值分别较术前有所升高（P>0.05）。曲美他嗪组CK-MB、cTnI术前-术后差值分别较对照组显著降低（P<0.05），h-FABP术前-术后差值较对照组有所降低（P>0.05）。对照组术前即刻、术后3h及术后6h h-FABP值逐渐增高，术后>10 h降低，但仍高于术前即刻水平（P<0.05）。结论：PCI术治疗对UAP患者术后心肌细胞可造成微小损伤，PCI术前至少24h以上给予曲美他嗪能够减轻UAP患者PCI术后的心肌损伤。

Abstract:

Objective ：To observe the effect of trimetazidine on myocardial injury in patients with unstable angina pectoris (UAP) undergoing percutaneous coronary intervention (PCI). Methods： Ninety-eight patients with UAP randomly were divided into trimetazidine group (37 cases) and control group (61 cases). Standard medical therapies were given to all 98 patients. The creatine kinase MB （CK-MB）, cardiac troponin I (cTnI) and heart-type fatty acid-bindling protein (h-FABP) were measured in all enrolled subjects before PCI right time and at 6:00 in the next day morning after PCI, and heart-type fatty acid-bindling protein (h-FABP) was also measured in another control group before PCI right time at 3 h, 6 hours and more than 10 h after PCI. Results：The levels of CK-MB and cTnI were elevated significantly after PCI in control group (P<0.05), but there were no significant changes in the increased levels of CK-MB and cTnI after PCI in the trimetazidine group (P>0.05). The levels of h-FABP were elevated at 10hs after PCI in control group and the trimetazidine group，but not significantly (P>0.05). However, the ascended levels of CK-MB (P<0.05), cTnI (P<0.05) and h-FABP (P>0.05) in the trimetazidine group were lower than those in control group. Furthermore, the levels of h-FABP were elevated step by step before PCI right time, 3 h and 6 h after in control group, though decreased 10 h after PCI, but still higher than before PCI right time(P<0.05). Conclusion：PCI may cause some minor damage of myocardium to patients with UAP. Trimetazidine therapy at more than 24 h before PCI can effectively protect myocardium in patients with UAP.

参考文献/References:

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相似文献/References:

备注/Memo

备注/Memo:

作者简介 邵帅（1985-），女，医师，硕士，研究方向：冠心病的基础与临床；通信作者：李广平，E-mail:tjcardiol@126.com。

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更新日期/Last Update: 2016-03-23