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《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:

21卷

期数:

2015年05期

页码:

426-429

栏目:

临床医学

出版日期:

2015-09-20

文章信息/Info

Title:

Relationship between serum bilirubin levels and osteoporosis in middle and old aged male patients with type 2 diabetes mellitus

文章编号:

1006-8147(2015)05-0426-04

作者:

?邢云芝; 李春君; 张秋梅; 于 倩; 于德民

?（天津医科大学代谢病医院内分泌科，天津内分泌研究所，卫生部激素与发育重点实验室，天津 300070）

Author(s):

XING Yun-zhi;  LI Chun-jun;  ZHANG Qiu-mei;  YU Qian ; YU De-min

（Department of Endocrinology, Metabolic Disease Hospital ，Tianjin Medical University, Tianjin Institute of Endocrinology, Key Laboratory of Hormone and Development Ministry of Health , Tianjin 300070，China）

关键词:

2型糖尿病; 骨质疏松症; 胆红素; 中老年

Keywords:

-

分类号:

R587.1

DOI:

-

文献标志码:

A

摘要:

目的：探讨2型糖尿病（T2DM）患者血清胆红素水平与骨质疏松症的相关性。方法：选择125例住院治疗的中老年男性2型糖尿病患者，测量其骨密度（BMD）值，据此将研究对象分为两组：合并骨量减少或骨质疏松组(OP)和正常骨密度组(NOP)。比较两组血清胆红素水平，并对胆红素和骨质疏松症的患病率及BMD进行相关性分析。结果：中老年男性T2DM合并OP的患病率为57.6%，统计学分析显示OP组与NOP组糖尿病病程、年龄、BMI、总胆红素（TBIL）、谷丙转氨酶（ALT）和尿素氮（BUN）水平存在显著差异，TBIL与骨质疏松患病率呈负相关，与各部位BMD呈显著正相关。Logistic多因素回归分析显示低TBIL水平是中老年男性T2DM患OP的独立危险因素。结论：胆红素轻度升高是中老年男性T2DM 骨质疏松症的一个重要保护因素。

Abstract:

Objective: To investigate the relationship between serum bilirubin levels and osteoporosis and osteopenia in middle and old aged male patients with type 2 diabetes mellitus (T2DM). Methods: The included 125 male patients with T2DM were divided to the osteoporosis group and the non-osteoporosis group according to BMD values. The following risk factors of the two groups were compared: the duration of T2DM, age, body mass index (BMI), liver and renal function and the correlations between the above risk factors with BMD in T2DM complicated by osteoporosis were analyzed. Results: The prevalence of osteoporosis and osteopenia in the middle and old aged male patients with type 2 diabetes mellitus was 57.6%，duration of diabetes, age, BMI, TBIL, ALT and BUN were significantly different between the two groups. TBIL were negatively correlated with the prevalence rate of osteoporosis and positively correlated with BMD. Multiple logistic regression analysis showed that low TBIL was an independent risk factor of OP in middle and old-aged male diabetic subjects. Conclusion: Bilirubin levels are significantly associated with OP in middle and old-aged male with type 2 diabetes and bilirubin may protect against OP in diabetic men.

参考文献/References:

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备注/Memo

备注/Memo:

作者简介邢云芝（1990-），女，硕士在读，研究方向：糖尿病及其并发症研究；

通信作者：于德民，Email:yudemintj@126.com。

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更新日期/Last Update: 2015-09-22