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《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:

21卷

期数:

2015年03期

页码:

185-188

栏目:

专题报道

出版日期:

2015-05-20

文章信息/Info

Title:

 Relationship between uric acid and CHADS₂/CHA₂DS₂-VASc Score in patients with nonvalvular atrial fibrillation

文章编号:

1006-8147（2015）03-0185-04

作者:

 陈延勋;  李广平

 

 （天津医科大学第二医院心脏科， 天津 300211）

Author(s):

 CHEN Yan-xun ;  LI Guang-ping

 （Department of Cardiology，The Second Hospital ,Tianjin Medical University ，Tianjin 300211，China）

关键词:

 ; 心房颤动;  尿酸;  CHADS₂ ; CHA₂DS₂-VASc

Keywords:

 ; atrial fibrillation;  uric acid ; CHADS₂; CHA₂DS₂-VASc

分类号:

R541.7+5

DOI:

-

文献标志码:

A

摘要:

 目的：探讨非瓣膜性心房颤动（房颤）患者尿酸（UA）与评估房颤患者血栓栓塞风险的CHADS₂、CHA₂DS₂-VAS c评分的关系。方法：连续入选非瓣膜性房颤188例，对患者进行CHADS₂和CHA₂DS₂-VASc评分，同时记录年龄、性别、伴发疾病、实验室指标、超声心动图结果等。根据CHADS₂、CHA₂DS₂-VASc评分将房颤发生血栓栓塞的风险分为低中危和高危组，比较房颤患者发生血栓风险低中危组与高危组各项指标的差异，同时探讨房颤患者UA与CHADS₂和CHA₂DS₂-VASc评分之间的关系。结果：无论何种分组方式，两组间年龄、高血压史、糖尿病史、冠心病史、脑卒中有统计学差异(P<0.05)，与低中危组相比，高危组年龄增加，UA、左房内径（LAD）、左室舒张末内径（LVEDD）增加，左室射血分数（LVEF）下降(P<0.05）。相关分析显示，尿酸、LAD、LVEDD和CHADS₂、CHA₂DS₂-VADSc评分呈正相关，LVEF和CHADS₂、CHA₂DS₂-VADSc评分呈负相关。结论:非瓣膜性房颤患者UA与CHADS₂、CHA₂DS₂-VASc评分呈正相关。

Abstract:

 Objective: To investigate the relationship between uric acid (UA) and CHADS2,CHA₂DS₂-VASc score for the evaluation of thromboembolism risk in patients with non-valvular atrial fibrillation(AF). Methods: One hundred and eighty-eight patients with nonvalvular Af(69 with paroxysmal Af and 119 with persistent AF) were collected in this study. The baseline clinical data were detected including age, sex, comorbidties, laboratory parameters and ecocardiography. CHADS₂ and CHA₂DS₂-VASc risk scores for each patient were calculated. According to CHADS₂ and CHA₂DS₂-VASc scores, the Af patients were divided into low-intermediate group and high risk group respectively， and the parameters between the two groups were compared ，andthe relationship between UA with AF evaluated． Results：The base characteristics between two groups had significant differences in age and comorbidities， in all groups method. Group with higher CHADS₂ and CHA₂DS₂-VASc scores had older age ,higher UA, left atrial diameter(LAD) ，left ventricular end-diastolic diameter(LVEDD) and lower left ventricular ejection fraction(LVEF). The correlation analysis showed UA，LVEDD，LAD and CHADS2,CHA₂DS₂-VASc score were positively correlated，however LVEF and CHADS2,CHA₂DS₂-VASc score were negatively correlated. Conclusion: UA is significantly correlated with CHADS₂ and CHA₂DS₂-VASc scores in patients with AF.

参考文献/References:

[1]European Heart Rhythm Association, European Association for Cardio-Thoracic Surgery, Camm A J, et al. Guidelines for the management of atrial fibrillation: the Task Force for the Management of Atrial Fibrillation of the European Society of Cardiology (ESC)[J]. Eur Heart J, 2010, 31(19): 2369

[2] Shankar A, Klein R, Klein B E, et al. The association between serum uric acid level and long-term incidence of hypertension:population-based cohort study[J]. J Hum Hypertens, 2006, 20(12): 937

[3] Fang J, Alderman M H. Serum uric acid and cardiovascular mortality:the NHANES I epidemio-

logic follow-up study,1971-1992,National Health and Nutrition Examination Survey[J].JAMA,

2000,283(18):2404

[4]Chonchol M, Shlipak M G, Katz R, et al. Relationship of uric acid with progression of kidney disease[J]. Am J Kidney Dis, 2007, 50(2): 239

[5]A Shankar B E, R Klein E A. Association between serum uric acid level and peripheral arterial disease[J]. Atherosclerosis, 2008, 196(2): 749

[6]Yoo Tae WOO, Sung K C, Shin H S, et al. Relationship between serum uric acid concentration and insulin resistance and metabolic syndrome[J]. Circ J, 2005, 69(8): 928

[7]Chao T F, Hung C L, Chen S J, et al. The association between hyperuricemia,left atrialsize and new-onset atrial fibrillation[J]. Int J Cardiol, 2013, 168（4): 4027

[8]Tamariz L, Agarwal S, Soliman E Z ,et al. Association of serum uric acid with incidentatrial fibr-

rillation[J]. AM J Cardiol, 2011,108(9):1272

[9]Go A S, Hylek E M, Phillips K A, et al. Prevalence of diagnosed atrial fibrillation in adults: National implications for rhythm management and stroke prevention: the AnTicoagulation and Risk Factors in Atrial Fibrillation (ATRIA) Study[J]. JAMA, 2001, 285(18): 2370

[10]Taillandier S, Olesen J B, Clémenty N, et al. Prognosis in patients with atrial fibrillation and CHA2DS2-VASc Score = 0 in a community-based cohort study[J]. J Cardiovasc Electrophysiol, 2012, 23(7): 708

[11]Numa S, Hirai T. Hyperuricemia and transesophageal echocardiogra-phic thromboembolic risk in patients with atrial fibrillation at clinically low-intermediate risk[J]. Circulation Journal, 2014, 78(7): 1600

[12]Su H M, Lin T H, Hsu P C, et al. Association of hyperuricemia with cardiac events in patients with atrial fibrillation[J]. Int J Cardiol, 2014, 172(2): 464

[13]Kaufman M，Guglin M . Uric acid in heart failure:a biomarker or therapeutic target[J]. Heart Fail Rev, 2013, 18(2): 177

[14]Mazzali M, Kanellis J, Han Lin, et al. Hyperuricemia induces a primary renal arteriolopathy in rats by a blood pressure-independent mechanism[J]. Am J Physiol Renal Physiol, 2002, 282(6): F991

[15]Palmer T M, Nordestgaard B G, Benn M, et al. Association of plasma uric acidwith ischaemic heart disease and blood pressure:mendelian randomisationanalysis of two large cohorts[J]. BMJ, 2013, 347: 4262

[16]Høieggen A, Alderman M H, Kjeldsen S E, et al. The impact of serum uric acid on cardiovascular outcomes in the Life study[J]. Kidney Int, 2004, 65(3): 1041

[17]Bandaru P, Shankar A. Association between serum uric acid levels and diabetes mellitus[J]. Int J Endocrinol, 2011, 2011: 604715

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备注/Memo

备注/Memo:

 作者简 陈延勋（1988-），男，硕士在读，研究方向：心血管内科；通信作者：李广平，E-mail:tjcardiol@126.com 。

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更新日期/Last Update: 2015-05-26