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[1]崔丽阳,岳天孚.高危型HPV持续感染的影响因素探讨[J].天津医科大学学报,2014,20(03):209-212.
　CUI Li-yang,YUE Tian-fu.Investigation on factors for persistent high-risk human papilloma virus infection[J].Journal of Tianjin Medical University,2014,20(03):209-212.
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高危型HPV持续感染的影响因素探讨(PDF)
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《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:
20卷
期数:
2014年03期
页码:
209-212
栏目:
临床医学
出版日期:
2014-05-20

文章信息/Info

Title:
Investigation on factors for persistent high-risk human papilloma virus infection
文章编号:
1006-8147(2014)03-0209-04
作者:
崔丽阳1; 2; 岳天孚3
(1.天津医科大学研究生院,天津 300070;2.天津市滨海新区大港医院妇产科,天津 300270;3.天津医科大学总医院妇产科,天津 300052)
Author(s):
CUI Li-yang1; 2;  YUE Tian-fu3
(1.Graduate School,Tianjin Medical University,Tianjin 300070,China;2.Department of Obstetrics and Gynecology,Tianjin Binhai Xinqu Dagang Hospital,Tianjin 300270，China；3.Department of Obstetrics and Gynecology, General Hospital, Tianjin Medical University ,Tianjin 300052，China)
关键词:
高危人乳头瘤病毒; 持续感染; 影响因素; 宫颈癌
Keywords:
 ;  high risk human papilloma virus;  automatic clearance;  influencing factors;  cervical cancer
分类号:
-
DOI:
-
文献标志码:
A
摘要:
目的：探讨高危型人乳头状瘤病毒(HR-HPV)持续感染的影响因素。方法：对148例HR-HPV阳性患者，进行问卷调查及随访，调查宫颈HR-HPV感染患者持续感染影响因素，探讨各因素与宫颈HR-HPV持续感染的关系。全部病例随访3年。结果：HR-HPV感染持续感染率为21.62%，自然清除率为69.59%，病毒清除时间为6个月到2年，中位数为18个月。经单因素分析及多因素非条件回归分析后结果提示，年龄、职业、最初病毒负荷量、性伴侣个数、配偶性伴侣个数、避孕方式以及生殖道各类炎症与HR-HPV感染持续感染呈正相关，是HPV持续感染的影响因素(P<0.01)。与患者是否吸烟、受教育程度及初次性生活年龄无明显相关性(P>0.05)。结论：年龄较大、不用避孕套避孕、性伴侣数目多、生殖道各种炎症或高病毒负荷量患者具有更高的HR-HPV持续感染率，应予以适当治疗并定期随访。对于无症状、低病毒负荷量的HR-HPV感染者宜密切随访，避免过度治疗。
Abstract:
Objective: To investigate the factors affecting high-risk human papilloma virus (HR-HPV) persistence. Methods: One hundred and forty eight HR-HPV positive cases with benign cervical pathologic diagnosis were enrolled in the study. The effective factors for persistent infection were analyzed. All patients were followed up for 3 years. Results: The rate of HR-HPV infection was 21.62%. HR-HPV infection spontaneous clearance rate was 69.59%, with the clearance time from 6 months to 2 years and the median viral clearance time of 18 months. Single factor analysis and multivariate regression analysis both showed that age, occupation, the initial viral load, number of sexual partners, sexual companion number, contraception and reproductive tract inflammation were the positive factors affecting the spontaneous HPV clearance (P <0.01). While smoking, level of education and age of first sexual experience had no obvious contribution (P >0.05). All the patients were continuously followed up. Conclusion: The results show that older women, sex without condom, the number of sexual partners, reproductive tract inflammation and high viral load of HR-HPV infection are factors for higher persistent infection rate. Thus, intensive screening and proper treatment are recommended.  The over treatment should be avoided for cases with asymptomatic or low viral load of HR-HPV infection.

参考文献/References:

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备注/Memo

备注/Memo:
作者简介 崔丽阳（1969-），女，硕士在读，研究方向：妇产科学；通信作者：岳天孚，E-mail: yuetianfu163@163.com。
更新日期/Last Update: 2014-05-12