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[1]杨晓玲,李 嘉,周莉,等.恩替卡韦初治代偿期和失代偿期乙肝肝硬化患者96周疗效比较[J].天津医科大学学报,2014,20(03):204-208.
 YANG Xiao-ling,LI Jia,ZHOU Li,et al.Comparison of entecavir efficacy in initial treatment for HBV patients with compensated and decompensated cirrhosis in 96 weeks[J].Journal of Tianjin Medical University,2014,20(03):204-208.
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恩替卡韦初治代偿期和失代偿期乙肝肝硬化患者96周疗效比较(PDF)
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《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:
20卷
期数:
2014年03期
页码:
204-208
栏目:
临床医学
出版日期:
2014-05-20

文章信息/Info

Title:
Comparison of entecavir efficacy in initial treatment for HBV patients with compensated and decompensated cirrhosis in 96 weeks
文章编号:
1006-8147(2014)03-0204-05
作者:
杨晓玲12李 嘉2周莉2王婧涵12刘均娟2高 敏2
(1.天津医科大学研究生院,天津 300070;2.天津市第二人民医院,天津市肝病医学研究所,天津 300192)
Author(s):
YANG Xiao-ling12 LI Jia2ZHOU Li2WANG Jing-han12LIU Jun-juan2GAO Min2
(1.Graduate School, Tianjin Medical University,Tianjin 300070,China;2.Tianjin Second People’s Hospital, Tianjin Liver Disease Institute, Tianjin 300192, China)
关键词:
乙肝肝硬化代偿期失代偿期恩替卡韦疗效
Keywords:
hepatitis B cirrhosis compensated hepatitis B cirrhosis decompensated entecavir efficacy
分类号:
-
DOI:
-
文献标志码:
A
摘要:
目的:比较代偿期和失代偿期乙肝肝硬化患者接受恩替卡韦(ETV)初始抗病毒治疗疗效。方法:回顾性分析初始应用ETV治疗96周的代偿期(n=54)和失代偿期(n=51)肝硬化患者,比较两组治疗前后不同时间点肝功能、HBV DNA阴转率、Child-Puge评分、食管静脉曲张程度、肝硬度的变化和区别及临床结局的情况。结果:代偿期组12周和24周时血清丙氨酸转氨酶(ALT)复常率明显高于失代偿期组(P<0.01),12周HBV DNA阴转率明显高于失代偿期组(P<0.05)。代偿期和失代偿期组血清白蛋白分别于12周、24周开始明显高于基线(P<0.01),胆碱酯酶(CHE)分别于24周、48周开始明显高于基线(P<0.01)。96周时,100%代偿期和96.1%失代偿期组Child-Pugh评分表现为改善和稳定;11例代偿期和4例失代偿期患者食管静脉曲张有不同程度减轻;两组患者肝硬度均减低,代偿期组减低更明显,治疗后与基线比较差异有统计学意义(P<0.01)。结论:经长期ETV抗病毒治疗,代偿期肝硬化患者可获得更显著的疗效 。
Abstract:
Objective: To compare the efficacy of entecavir in initial treatment for HBV patients with compensated and decompensated cirrhosis in 96 weeks Methods: Data of 54 compensated and 51 decompensated cirrhotic patients treated with ETV(>96 weeks) were collected, and the difference of liver function, HBV DNA negativity, Child–Puge score, the degree of esophageal varix and liver stiffness value were compared before and after treatment between the groups. Results: Alanine aminotransferase normalized rate was significantly higher at 12 and 24 wk(P<0.01) and HBV DNA negativity rate was higher at 12 wk(P<0.05) in the compensated group than in the decompensated group. In the two groups, serum albumin levels were much higher than the baseline at 12 and 24 wk, respectively (P<0.01), and serum cholinesterase levels were significantly higher than the baseline at 24 and 48 wk, respectively (P<0.01). The Child–Pugh score improved or remained steady in all compensated patients and 96.1% of decompensated patients. The degree of esophageal varix was lessened including for 11 compensated and 4 decompensated patients. Liver stiffness value was significantly decreased in the compensated group compared with the baseline (P<0.01). Conclusion: Long-term ETV treatment has superior effect on the compensated cirrhotic patients.

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备注/Memo

备注/Memo:
 作者简介 杨晓玲(1986-),女,硕士在读,研究方向:内科产染病学(肝病方向);通信作者:李嘉,E-mail: lijiadoctor1968@gmail.com
更新日期/Last Update: 2014-05-12