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《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:

19卷

期数:

2013年06期

页码:

499-501

栏目:

临床医学

出版日期:

2013-11-20

文章信息/Info

Title:

Hyperuricemia or gout associated with the severity of nonalcoholic fatty liver disease

作者:

郭彩云; 聂秀玲; 孙丽荣; 杨 洋

天津医科大学代谢病医院糖尿病痛风科， 天津 300070

Author(s):

GUO Cai-yun;  NIE Xiu-ling;  SUN Li-rong;  YANG Yang

Department of Diabetes and Gout, Metabolic Diseases Hospital, Tianjin Medical University, Tianjin 300070, China

关键词:

高尿酸血症; 痛风; 非酒精性脂肪肝 ; 代谢综合征

Keywords:

hyperuricemia; gout; nonalcoholic fatty liver disease; metabolic syndrome

分类号:

R575.5

DOI:

-

文献标志码:

A

摘要:

目的：探讨高尿酸血症/痛风对非酒精性脂肪肝（NAFLD）严重程度的影响。方法：选取痛风患者86例，高尿酸血症患者77例，同期体检健康人群86例，测量身高、体质量、血压、腰围、臀围、空腹静脉血糖（FPG）、空腹胰岛素（FINS）、糖化血红蛋白（HbA1c）、血脂、肝功能、肾功能、血尿酸（SUA），计算体质指数（BMI）、胰岛素抵抗指数（HOMA-IR）、肾小球滤过率（eGFR），并进行肝脏B超检查，比较各组的NAFLD的总检出率及轻、中、重度脂肪肝检出率及生化指标。结果：痛风组及高尿酸血症组SUA、BMI、腰围、MAP、FPG、FINS、HOMA-IR、HbA1c、ALT、Scr、TG、LDL均显著高于对照组，而HDL、eGFR显著低于正常组（P<0.05）；痛风组GGT、BUN显著高于正常组（P<0.05）；痛风组及高尿酸血症组NAFLD总检出率及轻、中度脂肪肝检出率均显著高于对照组（45.3%、26.7%、17.4% vs 35.1%、27.3%、6.5% vs 23.3%、17.4%、4.7%，P<0.05）；Logistic回归分析显示SUA、TG、BMI是NAFLD的独立危险因素，OR值分别为1.004、1.394和1.213。结论：高尿酸血症及痛风是NAFLD进展的重要高危因素，TG、肥胖、SUA参与NAFLD发生发展。

Abstract:

Objective: To evaluate the severity of nonalcoholic fatty liver disease(NAFLD) in patients with hyperuricemia or gout． Methods: Seventy-seven patients with asymptomatic hyperuricemia, 86 patients with gout and 86 healthy controls were studied. NAFLD presence and severity were defined by ultrasonographic detection of steatosis in the absence of other liver diseases. Other biochemical variables were measured by routine methods. Results：Compared with healthy controls，the SUA, BMI, waist circumference, MAP, FPG, FINS, HOMA-IR, HbA1c, ALT, Scr, TG, LDL were significantly higher in hyperuricemia and gout groups, HDL, eGFR inverse. GGT,BUN in gout were higher than in healthy controls. The detection rate of NAFLD were significantly higher in hyperuricemia and gout groups than those in control group for mild and moderate fatty liver as well as total average(45.3%, 26.7%, 17.4% vs 35.1%, 27.3%, 6.5% vs 23.3%, 17.4%, 4.7%; P<0.05). Logistic analysis showed that SUA,TG and BMI were the independent risk factors of NAFLD and OR were 1.004, 1.394 and 1.213 respectively. Conclusion：Hyperuricemia and gout are the essential risk factors of the progress of NAFLD and closely related to the severity of the fatty liver ultrasound and metabolic syndrome.

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[2]聂秀玲,宋林凌,孙丽荣.痛风患者血红蛋白水平与非酒精性脂肪性肝病关系的研究[J].天津医科大学学报,2020,26(06):533.
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备注/Memo

备注/Memo:

作者简介 郭彩云（1988-），女，硕士在读，研究方向：内分泌与代谢病；通信作者：孙丽荣，E-mail: augustnie@eyou.com。

常用功能

更新日期/Last Update: 2013-12-20