|本期目录/Table of Contents|

[1]林宪仁,何 佳,巴 一,等.Girdin蛋白在脑胶质瘤组织中的表达及其与临床病理特征和预后的关系[J].天津医科大学学报,2015,21(05):397-400.
　LIN Hsien-jen,HE Jia,BA Yi,et al.Expression of Girdin in glioma tissues and its relationship with pathological clinical characteristics and prognosis of the patient[J].Journal of Tianjin Medical University,2015,21(05):397-400.
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Girdin蛋白在脑胶质瘤组织中的表达及其与临床病理特征和预后的关系(PDF)
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《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:
21卷
期数:
2015年05期
页码:
397-400
栏目:
临床医学
出版日期:
2015-09-20

文章信息/Info

Title:
Expression of Girdin in glioma tissues and its relationship with pathological clinical characteristics and prognosis of the patient
文章编号:
1006-8147（2015）05-0397-04
作者:
林宪仁1; 何 佳1 ; 巴 一1; 马勇杰2
?(1.天津医科大学肿瘤医院,国家肿瘤临床医学研究中心,天津市肿瘤防治重点实验室,天津 300060;2.天津医科大学肿瘤医院肿瘤研究所细胞生物学实验室,天津 300060）
Author(s):
LIN Hsien-jen1;  HE Jia1;  BA Yi1;  MA Yong-jie2
(1.Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin Key Laboratory of Cancer Prevention and Therapy, Tianjin 300060, China.2. Laboratory of Cancer Cell Biology ，Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, China)
关键词:
Girdin蛋白; 脑胶质瘤; 免疫组化; 预后
Keywords:
protein Girdin;  glioma;  immunohistochemistry;  prognosis
分类号:
R739.4
DOI:
-
文献标志码:
A
摘要:
目的:研究Girdin在人脑胶质瘤组织中表达的特点及其与病理特征和预后的关系。方法:应用SP免疫组化技术测定100例脑胶质瘤组织中Girdin的表达情况,分析Girdin表达与患者临床病理特征的关系,Kaplan-Meier生存曲线分析Girdin表达与预后的关系,用Cox比例风险分析影响生存结果的独立预后因素。结果: Girdin在各病理级别脑胶质瘤中均有表达,Girdin在III～IV级脑胶质瘤表达高于I～II级脑胶质瘤,差异具有统计学意义。Girdin表达与脑胶质瘤恶性程度、肿瘤大小呈正相关,Girdin高表达组患者的预后比低表达组患者差,Cox比例风险分析提示Girdin、年龄、病理学分级及肿瘤大小是脑胶质瘤患者预后影响因素。结论: Girdin可能在促进恶性脑胶质瘤发生发展中起重要作用。
Abstract:
Objective: To investigate the characteristics of Girdin expression and its expression in glioma patients with malignancy grade in the prognosis of these patients. Methods: Girdin expression was investigated using the SP method in glioma tissues in 100 specimens. Kaplan-Meier survival was constructed to assess Girdin expression and living status. Cox Proportional hazard analysis was used to analyze the factors affecting survival prognosis. Results: Protein expression level and pathological grade of glioma were both increased accordingly, patients with high and low protein expressions had a significantly different survival times, where patients with low Girdin expression had higher survival times as compared to patients with high Girdin expression．Cox Proportional Hazard analysis found that Girdin expression, age, pathology grade, and size of glioma were all factors affecting the prognosis of glioma patients. Conclusion: Expression of the protein Girdin is positively correlated with pathological grade of gliomas, and patients with high Girdin expression have poorer prognosis, suggesting that Girdin may play a role in tumor genesis and progression of gliomas.

参考文献/References:

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备注/Memo

备注/Memo:
作者简介 林宪仁（1986－）,男,硕士在读；研究方向：神经肿瘤中胶质瘤的基础与临床研究;通信作者:马勇杰,E-mail:yongjiemagu@aliyun.com。
更新日期/Last Update: 2015-09-22