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《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:

32卷

期数:

2026年02期

页码:

165-170

栏目:

临床医学

出版日期:

2026-03-20

文章信息/Info

Title:

Retrospective study on the correlation between Meprin-α， Gal-3 and acute coronary syndrome

文章编号:

1006-8147(2026)02-0165-06

作者:

马振华; 李 琦; 魏丽萍

（天津市人民医院，南开大学第一附属医院心内科，天津300121）

Author(s):

MA Zhenhua;  LI Qi; WEI Liping

（Department of Cardiology， Tianjin People′s Hospital， The First Affiliated Hospital of Nankai University， Tianjin 300121， China）

关键词:

急性冠脉综合征; Meprin-α; 半乳糖凝集素-3

Keywords:

acute coronary syndrome;  meprin-α;  galectin-3

分类号:

R541.4

DOI:

10.20135/j.issn.1006-8147.2026.02.0165

文献标志码:

A

摘要:

目的：探讨Meprin-α和半乳糖凝集素3（Gal-3）与急性冠脉综合征（ACS）之间的关系。方法：选取2022年1月至2022年12月于天津市人民医院心内科接受冠状动脉造影检查的患者206例，将造影检查结果确诊为ACS的169例患者纳入ACS组，检查结果未见异常的37例患者纳入正常对照组。测定并比较两组患者血清Meprin-α和Gal-3的水平，分析其与ACS发生之间的相关性，比较二者在ACS不同亚组即不稳定型心绞痛（UAP）、急性非ST段抬高型心肌梗死（NSTEMI）与急性ST段抬高型心肌梗死（STEMI）之间的水平，并评估二者对ACS及其亚组的诊断效能。结果：ACS组血清Meprin-α水平显著高于对照组（Z=-3.503，P＜0.05）。在ACS亚组中NSTEMI组Meprin-α水平较UAP组显著升高（P＜0.05）。Gal-3水平在ACS各亚组间无统计学差异（P＞0.05）。二元Logistic回归分析显示，血清Meprin-α升高是ACS发生的独立危险因素（OR=1.493，95%CI： 1.141~1.955，P＜0.05）。受试者工作特征（ROC）曲线分析显示，Meprin-α不仅可预测ACS的发生（AUC=0.683 9，P＜0.05），且对UAP（AUC=0.640 3，P＜0.05）、NSTEMI（AUC=0.795 8，P＜0.05）以及STEMI（AUC=0.692 5，P＜0.05）均具有一定的预测价值。Gal-3与ACS发生之间无关（P＞0.05）。结论：Meprin-α可能参与ACS的发生、发展，并有望成为评估ACS的潜在生物标志物；而Gal-3与ACS不相关。

Abstract:

Objective： To investigate the association between Meprin-α， Galectin-3 （Gal-3）， and acute coronary syndrome （ACS）. Methods：A total of 206 patients who underwent coronary angiography in the Department of Cardiology at Tianjin People′s Hospital from January to December 2022 were enrolled. Among them， 169 patients diagnosed with ACS based on angiography results were assi-gned to the ACS group， while 37 patients with normal angiography findings were assigned to the control group. Serum Meprin-α and Gal-3 were measured and compared between the two groups of patients， and the correlation of these biomarkers with ACS occurrence was analyzed. The levels of two biomarkers indistinct ACS subgroups specifically unstable angina pectoris（UAP）， acute non-ST-elevation myocardial infarction （NSTEMI）， and acute ST-elevation myocardial infarction （STEMI） were compared，and their diagnostic performance for ACS and its subgroups were evaluated. Results： Serum Meprin-α levels were significantly higher in the ACS group compared with the control group （Z=-3.503，P<0.05）. In ACS subgroups， patients with NSTEMI exhibited significantly higher levels of Meprin-α compared to those with UAP （P<0.05）. No statistically significant differences in Gal-3 levels were found across the ACS subgroups （P>0.05）. Binary Logistic regression analysis indicated that elevated serum Meprin-α was an independent risk factor for ACS （OR=1.493， 95% CI： 1.141-1.955， P<0.05）. Receiver operating characteristic （ROC） curve analysis demonstrated that Meprin-α not only predicted occurrence of the ACS（AUC=0.683 9， P<0.05）， but also showed predictive value for UAP （AUC=0.640 3， P<0.05）， NSTEMI （AUC=0.795 8， P<0.05）， and STEMI （AUC=0.692 5， P<0.05）. However， no statistically significant association was found between Gal-3 and ACS occurrence（P>0.05）. Conclusion： Meprin-α may be involved in the pathogenesis of ACS and has the potential to serve as a biomarker for ACS assessment. In contrast， Gal-3 is not associated with ACS.

参考文献/References:

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备注/Memo

备注/Memo:

基金项目 天津市科技计划项目面上项目（23JCYBJC01470）；天津市卫生健康委员会中医中西医结合科研项目（2023055）；天津市人民医院重点项目（2023YJZD003）
作者简介 马振华（1990-），男，医师，硕士，研究方向：心血管内科；通信作者：魏丽萍，E-mail：weilipingme@163.com。

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更新日期/Last Update: 2026-03-20