|本期目录/Table of Contents|

[1]蒋腾,朱仲玲综 述,阎昭审 校.二甲双胍抗肿瘤作用的研究进展[J].天津医科大学学报,2020,26(06):577-579,584.
点击复制

二甲双胍抗肿瘤作用的研究进展(PDF)
分享到：

《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:
26卷
期数:
2020年06期
页码:
577-579,584
栏目:
综述
出版日期:
2020-11-20

文章信息/Info

Title:
-
作者:
蒋腾1; 朱仲玲1综 述; 阎昭1; 2审 校
1.天津医科大学肿瘤医院临床药理研究室，国家肿瘤临床医学研究中心，天津市“肿瘤防治”重点实验室，天津市 恶性肿瘤临床医学研究中心，天津300060；2.天津市药物临床研究技术创新中心，天津 300182
Author(s):
-
关键词:
二甲双胍; AMPK; 抗肿瘤; 脂质合成; 自噬; 免疫功能; 肠道菌群
Keywords:
-
分类号:
R961
DOI:
-
文献标志码:
A
摘要:
二甲双胍作为治疗2型糖尿病的一线药物，研究表明它具有预防多种肿瘤发生的作用，并且表现出一定的抗肿 瘤作用。二甲双胍可以通过AMP活化蛋白激酶（AMPK）抑制脂质合成、控制自噬、诱导细胞周期停滞、激活Foxo3a。也 可以不依赖于AMPK发挥增强免疫功能、抑制未折叠蛋白反应（UPR）、抑制微管蛋白的表达、激活DNA损伤反应、调节 肠道菌群的作用。探究二甲双胍的抗肿瘤作用机制，为二甲双胍在治疗肿瘤方面的合理用药提供理论依据。
Abstract:
-

参考文献/References:

[1] Practice Committee of the American Society for Reproductive Medicine. Role of metformin for ovulation induction in infertile patients with polycystic ovary syndrome（PCOS）：a guideline[J]. Fertil Steril，2017，108（3）： 426
[2] Armen Y，Alexander A S. Metformin： mechanisms in human obesity and weight loss[J]. Curr Obes Rep ，2019，8（2）：156
[3] Barzilai N，Crandall J P，Kritchevsky S B，et al. Metformin as a tool to target aging[J]. Cell Metab，2016，23（6）：1060
[4] Morales D R，Morris A D. Metformin in cancer treatment and prevention[J]. Annu Rev Med，2015，66 ：17
[5] Pollak M. The effects of metformin on gut microbiota and the immune system as research frontiers [J]. Diabetologia，2017，60（9）：1662
[6] Moro M，Caiola E，Ganzinelli M，et al. Metformin enhances cisplatin-induced apoptosis and prevents resistance to cisplatin in co-mutated KRAS/LKB1 NSCLC[J]. J Thorac Oncol，2018，13（11）：1692
[7] Hsiuchen C，David C C. Mitochondrial dynamics in regulating the unique phenotypes of cancer and stem cells[J]. Cell Metab，2017， 26（1）：39
[8] Li Y，Xu S Q，Mihaylova M M，et al. AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice[J]. Cell Metab，2011， 13 （4）：376
[9] Yan W，Xu W B，Yan Z X，et al. Metformin induces autophagy and G0/G1 phase cell cycle arrest in myeloma by targeting the AMPK/mTORC1 and mTORC2 pathways[J]. J Exp Clini Cancer Res，2018， 37（1）：63
[10] Saladini S，Michele A，Barreca F，et al. Metformin impairs glutamine metabolism and autophagy in tumour cells[J]. Cells，2019，8（1）：49
[11] Yudhani R D，Astuti I，Mustofa M，et al. Metformin modulates cyclin D1 and P53 expression to inhibit cell proliferation and to induce apoptosis in cervical cancer cell lines[J]. Asian Pac J Cancer Prev， 2019，20（6）：1667
[12] Gwak H，Kim Y，An H，et al. Metformin induces degradation of cyclin D1 via AMPK/GSK3β axis in ovarian cancer[J]. Mol Carcinog，2017，56（2）： 349
[13] Sin-Ting W，Hsiu J H，Jaw-Town L，et al. Simvastatin-induced cell cycle arrest through inhibition of STAT3/SKP2 axis and activation of AMPK to promote p27 and p21 accumulation in hepatocellular carcinoma cells[J]. Cell Death Dis，2017，8（2）：e2626
[14] Zhou X J，Kuang Y C，Liang S M，et al. Metformin inhibits cell proliferation in SKM-1 cells via AMPK-mediated cell cycle arrest[J]. J Pharmacol Sci，2019，141（4）：146
[15] Liu Y，Ao X，Ding W，et al. Critical role of FOXO3a in carcinogenesis[J]. Mol Cancer，2018，17（1 ）：104
[16] Chou C C，Lee K H，Lai I L，et al. AMPK reverses the mesenchymal phenotype of cancer cells by targeting the Akt-MDM2-Foxo3a signaling axis[J]. Cancer Res，2014，74（17）：4783
[17] Sato A，Sunayama J，Okada M，et al. Glioma-initiating cell elimination by metformin activation of FOXO3 via AMPK[J]. Stem Cells Transl Med，2012，1（11）：811
[18] Eikawa S，Nishida M，Mizukami S，et al. Immune-mediated antitumor effect by type 2 diabetes drug， metformin[J]. Proc Natl Acad Sci U S A，2015，112（6）：1809
[19] Cha J H，Yang W H，Xia W Y，et al. Metformin promotes antitumor immunity via endoplasmic- reticulum-associated degradation of PD-L1[J]. Mol Cell，2018，71（4）：606
[20] Rufo N D，Agostinis P. The unfolded protein response in immunogenic cell death and cancer immunotherapy[J]. Trends Cancer，2017，3（9）：643
[21] Cubillos-Ruiz J R，Glimcher L H. Tumorigenic and immunosuppressive effects of endoplasmic reticulum stress in cancer[J]. Cell，2017， 168（4）：692
[22] Vavilis T，Delivanoglou N，Aggelidou E，et al. Oxygen-glucose deprivation（OGD） modulates the unfolded protein response（UPR） and inflicts autophagy in a PC12 hypoxia cell line model[J]. Cell Mol Neurobiol，2016，36（5）：701
[23] Amelia L P，Teo W S，Mccarroll J A，et al. An emerging role for tubulin isotypes in modulating cancer biology and chemotherapy resistance[J]. Int J Mol Sci，2017，18（7）：1434
[24] Person F，Wilczak W，Hube-Magg C，et al. Prevalence of βIII-tubulin（TUBB3） expression in human normal tissues and cancers[J].Tumor Biology，2017，39（10）：101042831771216
[25] Oliveras-Ferraros C V，Menendez J A. Genome-wide inhibitory impact of the AMPK activator metformin on [kinesins，tubulins，histones，auroras and polo-like kinases] M-phase cell cycle genes in human breast cancer cells[J]. Cell Cycle，2009，8（10）：1633
[26] Menendez J A，Cufí S，Oliveras-Ferraros C，et al. Metformin and the ATM DNA damage response（DDR） ：accelerating the onset of stress-induced senescence to boost protection against cancer[J]. Aging， 2011，3（11）：1063
[27] Tien S D，Chang H H，Hauer M，et al. Metformin alters the duodenal microbiome and decreases the incidence of pancreatic ductal adenocarcinoma promoted by diet-induced obesity[J]. Am J Physiol Gastrointest Liver Physiol，2019，317（6）：G763
[28] Cherney D I，Tony K L. A gut feeling for metformin[J]. Cell Metab，2018，28（6）：808
[29] Cariello M，Ducheix S，Maqdasy S，et al. LXRs，SHP，and FXR in prostate cancer：enemies or menage a quatre with AR[J]. Nucl Recept Signal，2018，15：1550762918801070
[30] You W J，Li L J，Sun D Q，et al. Farnesoid X receptor constructs an immunosuppressive microenvironment and sensitizes FXRhigh PD-L1low NSCLC to anti–PD-1 immunotherapy[J]. Cancer Immunol Res，2019，7（6）：990
[31] Fu T，Coulter S，Yoshihara E，et al. FXR regulates intestinal cancer stem cell proliferation[J]. Cell，2019，176（5）：1098
[32] Arrieta O，Barron F，Padilla M S，et al. Effect of metformin plus tyrosine kinase inhibitors compared with tyrosine kinase inhibitors alone in patients with epidermal growth factor receptor- mutated lung adenocarcinoma： a phase 2 randomized clinical trial[J]. JAMA Oncol，2019，5（11）： e192553
[33] Kristen A M，Xian Z，Patrick M F，et al. A randomized phase Ⅱ study of metformin plus paclitaxel/carboplatin/bevacizumab in patients with chemotherapy-na?觙ve advanced or metastatic nonsquamous non-small cell lung cancer[J]. Oncologist，2018，23（7）：859
[34] Parikh A B，Peter K，Nicholas R，et al. Metformin as a repurposed therapy in advanced non-small cell lung cancer（NSCLC）：results of a phase Ⅱtrial[J]. Invest New Drugs，2017，35（6）：813
[35] Nanni O，Amadori D，Rocca A，et al. Metformin plus chemotherapy versus chemotherapy alone in the first-line treatment of HER2-negative metastatic breast cancer.The MYME randomized，phase 2 clinical trial[J]. Breast Cancer Res Treat，2019，174（2）：433
[36] Higurashi T，Hosono K，Takahashi H，et al. Metformin for chemoprevention of metachronous colorectal adenoma or polyps in post-polypectomy patients without diabetes： a multicentre double-blind ，placebo-controlled，randomised phase 3 trial[J]. Lancet Oncol，2016， 17（4）：475

相似文献/References:

[1]刘 倩,胡 芳,牛文彦.AMPK腺病毒载体在小鼠骨骼肌中的表达和作用[J].天津医科大学学报,2016,22(01):1.
　LIU Qian,HU Fang,NIU Wen-yan.Effect and expression of AMPK adenovirus on mouse skeletal muscle[J].Journal of Tianjin Medical University,2016,22(06):1.
[2]刘 豫,薄志强,张志宏.糖尿病及二甲双胍对上尿路肿瘤术后复发的影响[J].天津医科大学学报,2017,23(01):53.
　LIU Yu,BO Zhi-qiang,ZHANG Zhi-hong.Effect of diabetes mellitus and metformin on intravesical recurrence after radical operation in patients with upper urinary tract urothelial carcinoma[J].Journal of Tianjin Medical University,2017,23(06):53.
[3]吕晓婷,洪宇桁,牛文彦.短链脂肪酸对C2C12小鼠骨骼肌细胞AMPK的作用研究[J].天津医科大学学报,2019,25(01):1.
　LV Xiao-ting,HONG Yu-heng,NIU Wen-yan.Effect of short-chain fatty acids on AMPK in mouse C2C12 skeletal muscle cells[J].Journal of Tianjin Medical University,2019,25(06):1.
[4]徐凯月,孟祥雪,黄 传,等.间歇性低氧干预提高心梗大鼠心功能和运动耐量[J].天津医科大学学报,2019,25(05):459.
　XU Kai-yue,MENG Xiang-xue,HUANG Chuan,et al.Intermittent hypoxia intervention improves cardiac function and exercise tolerance of rats with myocardial infarction[J].Journal of Tianjin Medical University,2019,25(06):459.
[5]任 静,朱仲玲 综 述,阎 昭 审 校.AMPK对脂质代谢调控作用的研究进展[J].天津医科大学学报,2019,25(05):540.
[6]苏悦,史昱,姜俐洋,等.间歇性低氧干预对脑缺血大鼠神经功能恢复的影响[J].天津医科大学学报,2021,27(03):222.
　SU Yue,SHI Yu,JIANG Li-yang,et al.Effect of intermittent hypoxic intervention on neurological function recovery in cerebral ischemic rats[J].Journal of Tianjin Medical University,2021,27(06):222.
[7]郭洋,张露露,牛文彦.二甲双胍通过调控MSTN抑制小鼠骨骼肌细胞C2C12分化[J].天津医科大学学报,2023,29(01):41.
　GUO Yang,ZHANG Lu-lu,NIU Wen-yan.Metformin inhibits the differentiation of C2C12 murine skeletal muscle cells by regulating MSTN[J].Journal of Tianjin Medical University,2023,29(06):41.
[8]孙亚朝,邓邦利,牛文彦.短链脂肪酸对肝细胞糖脂代谢调节的作用机制研究[J].天津医科大学学报,2023,29(02):126.
　SUN Ya-zhao,DENG Bang-li,NIU Wen-yan.Study of the mechanism of short chain fatty acids-regulated glucose and lipid metabolism in hepatocytes[J].Journal of Tianjin Medical University,2023,29(06):126.

备注/Memo

备注/Memo:
文章编号 1006-8147（2020）06-0577-03
基金项目 天津市科技计划项目(18ZXXYSY00070)
作者简介 蒋腾(1992-)，男，硕士在读，研究方向：药理学；通信作者：阎昭，E-mail:yanzhaopaper@163.com。
更新日期/Last Update: 2020-11-20