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[1]王玲莉,于欢,张冬丽,等.中国南海海绵Ircinia sp.中化学成分的研究[J].天津医科大学学报,2020,26(04):306-308.
　WANG Ling-li,YU Huan,ZHANG Dong-li,et al.Studies on chemical constituents of the marine sponge Ircinia sp. from the South China Sea[J].Journal of Tianjin Medical University,2020,26(04):306-308.
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中国南海海绵Ircinia sp.中化学成分的研究(PDF)
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《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:
26卷
期数:
2020年04期
页码:
306-308
栏目:
基础医学
出版日期:
2020-07-15

文章信息/Info

Title:
Studies on chemical constituents of the marine sponge Ircinia sp. from the South China Sea
文章编号:
1006-8147(2020)04-0306-03
作者:
王玲莉; 于欢; 张冬丽; 乔卫; 唐生安
（天津医科大学药学院天然药物学系，天津市临床药物关键技术重点实验室，天津 300070）
Author(s):
WANG Ling-li;  YU Huan;  ZHANG Dong-li;  QIAO Wei;  TANG Sheng-an
（Department of Natural Medicines, School of Pharmacy，Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics (Theranostics), Tianjin Medical University, Tianjin 300070, China）
关键词:
南海海绵; Ircinia sp.; 结构鉴定; 甾醇
Keywords:
marine sponge;  Ircinia sp.;  structure identification;  sterol
分类号:
R284.2
DOI:
-
文献标志码:
A
摘要:
目的：对采自广西涠洲岛海域海绵Ircinia sp.进行化学研究以获得结构新颖的新化合物。方法：运用高速逆流色谱、凝胶渗透色谱、硅胶柱色谱和半制备型高效液相色谱等多种技术分离纯化，再通过氢谱、碳谱和质谱等谱学解析方法鉴定出单体成分的结构。结果：从海绵Ircinia sp.中分离鉴定出5个化合物，分别命名为cholest-7-en-6R-methoxy-3S,5R-diol(1)，cholest-7-en-3S,5R,6R-triol(2)，cholest-7,22-dien-6R-methoxy-3S,5R-diol(3)，鲨肝醇(4)和邻苯二甲酸正丁酯(5)。结论：化合物1～3为首次从该属海绵中分离得到。
Abstract:
Objective: Chemical components of the marine sponge Ircinia sp. from the South China Sea were studied in order to obtain new compounds with novel structures. Methods: HSCCC, GPC, Silica gel column chromatography and semi-preparative HPLC were preformed to isolate and purify the dichloromethane extract of the marine sponge Ircinia sp. The structures of compounds were identified by spectroscopic methods such as 1H NMR, 13C NMR, 2D NMR and MS. Results: Five compounds were obtained and identified, including three steroids, namely cholest-7-en-6R-methoxy-3S,5R-diol（１）, cholest-7-en-3S,5R,6R-triol（２） and cholest-7,22-dien-6R-methoxy-3S,5R-diol（３）, one diol, namely batyl alcohol（4）, and one lipid, namely dibutyl phthalate （５）. Conclusion: Compounds 1-3 are obtained for the first time from the genus Ircinia.

参考文献/References:

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备注/Memo

备注/Memo:
基金项目 天津市自然科学基金重点项目（16JCZDJC32600）；中国博士后基金项目（2016M591399）
作者简介 王玲莉（1993-），女，硕士在读，研究方向：天然药物化学;
通信作者：唐生安，E-mail：tangshengan@tmu.edu.cn。
更新日期/Last Update: 2020-07-15