|本期目录/Table of Contents|

[1]周月,刘欢.巴戟天提取物联合GABA/茶氨酸改善小鼠睡眠作用的研究[J].天津医科大学学报,2020,26(02):114-117.
　ZHOU Yue,LIU Huan.Study on the sleep improvement effect of Morinda officinalis combined with GABA/L-Theanine in mice[J].Journal of Tianjin Medical University,2020,26(02):114-117.
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巴戟天提取物联合GABA/茶氨酸改善小鼠睡眠作用的研究(PDF)
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《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:
26卷
期数:
2020年02期
页码:
114-117
栏目:
基础医学
出版日期:
2020-04-30

文章信息/Info

Title:
Study on the sleep improvement effect of Morinda officinalis combined with GABA/L-Theanine in mice
文章编号:
1006-8147(2020)02-0114-04
作者:
周月; 刘欢
（天津医科大学公共卫生学院营养与食品卫生学系，天津 300070）
Author(s):
ZHOU Yue; LIU Huan
（Department of Nutrition and Food Science,School of Public Health,Tianjin Medical University,Tianjin 300070,China）
关键词:
巴戟天提取物; 改善睡眠; 小鼠
Keywords:
Morinda officinalis; sleep improvement;  mice
分类号:
R151+R96
DOI:
-
文献标志码:
A
摘要:
目的：研究巴戟天提取物联合γ-氨基丁酸（GABA）/茶氨酸对小鼠睡眠的改善作用。方法：18～20 g健康雄性ICR种小鼠，按体质量随机分组，每天经口灌胃不同剂量的GABA/茶氨酸混合物、巴戟天/GABA/茶氨酸混合物或阴性对照物（蒸馏水），30 d后进行直接睡眠实验、延长戊巴比妥钠睡眠时间实验、戊巴比妥钠阈下剂量催眠实验和巴比妥钠睡眠潜伏期实验。结果：GABA/茶氨酸、巴戟天/GABA/茶氨酸各剂量组均无直接睡眠作用，也不能增加阈下剂量入睡动物数（P>0.05）；巴戟天/GABA/茶氨酸两个剂量组的小鼠睡眠时间延长、睡眠潜伏期缩短（P<0.05），GABA/茶氨酸低剂量组的睡眠时间和睡眠潜伏时间与正常对照组相比差异无统计学意义（P>0.05）；GABA/茶氨酸高剂量组可延长戊巴比妥钠睡眠时间、缩短巴比妥钠睡眠潜伏期（P<0.05）。结论：巴戟天/GABA/茶氨酸改善睡眠功能的作用优于GABA/茶氨酸。
Abstract:
Objective: To study the effect of Morinda officinalis combined with gamma－amino butyric acid（GABA）/theanine on sleep improvement in mice. Methods: Healthy male ICR mice(18-20 g) were randomly divided into five groups according to their body weight and were given different doses of GABA/L-Theanine Mixture, Morinda officinalis/GABA/L-Theanine Mixture or negative control substance (distilled water) orally each day. After 30 days of consecutive administration, the direct sleep test, the sleep-extending test with sodium pentobarbital, the sleep-producing test with subthreshold dose of sodium barbital and the incubation period test with sodium pentobarbital were conducted. Results: There was no direct sleep effect in GABA/L-Theanine and Morinda officinalis/GABA/L-Theanine groups and no increase in the number of animals falling asleep at subthreshold dose(P>0.05); the sleep time of Morinda officinalis/GABA/L-Theanine groups was prolonged and the sleep latency was shortened (P<0.05); there was no significant difference in the sleep time and sleep latency between GABA/L-Theanine low dose group and normal control group(P>0.05). The sleep time of pentobarbital sodium was prolonged and the sleep latency of barbital sodium was shortened in the high dose group of GABA/L-Theanine (P<0.05). Conclusion: Morinda officinalis/GABA/L-Theanine has better effect on improving sleep function than GABA/L-Theanine.

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备注/Memo

备注/Memo:
作者简介 周月(1993- ),女,硕士在读,研究方向：营养与慢性疾病；
通信作者: 刘欢,E-mail:liuhuan@tmu.edu.cn。
更新日期/Last Update: 2020-06-02