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《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:

25卷

期数:

2019年06期

页码:

638-641

栏目:

临床医学

出版日期:

2019-11-20

文章信息/Info

Title:

Clinical observation of Olanzapine in the treatment of senile type 2 diabetes mellitus complicated with mental disorder

文章编号:

1006-8147(2019)06-0638-04

作者:

和西波¹; 2 ; 毛富强¹ ; 刘艳艳² ; 高艳杰²

（1.天津医科大学基础医学院精神卫生学系，天津 300070；2.天津市安宁医院，天津 300300）

Author(s):

HE Xi-bo¹; 2;  MAO Fu-qiang¹;  LIU Yan-yan²;  GAO Yan-jie²

（1. Department of Mental Health, School of Basic Medical Sciences, Tianjin Medical University, Tianjin 300070, China; 2.Tianjin Anning Hospital, Tianjin 300300, China）

关键词:

老年; T2DM; 精神障碍; 精神病治疗

Keywords:

old age;  T2DM;  mental disorder;  psychiatric treatment

分类号:

R587.2

DOI:

-

文献标志码:

A

摘要:

目的：探究老年2型糖尿病（T2DM）伴发精神障碍抗精神病治疗效果。方法：选取我院2016年3月至2018年2月收治的老年T2DM伴发精神障碍患者94例，使用随机数字表法将其分为对照组（47例）及治疗组（47例），对照组仅给予T2DM对症治疗，治疗组在其基础上施加抗精神病药物治疗。比较两组治疗前后血糖、白介素-6（IL-6）、肿瘤坏死因子-α（TNF-α）、脑源性神经营养因子（BDNF）水平及简明精神病量表（BPRS）、SF-36生活质量量表评分。结果：治疗前两组FBG、2hPG、HbAlc、IL-6、TNF-α、BDNF水平及BPRS、SF-36生活质量量表评分差异不显著（P>0.05），治疗后，治疗组FBG、2hPG、HbAlc、IL-6、TNF-α、水平及BPRS评分显著低于对照组，治疗组BDNF水平、SF-36生活质量量表评分显著高于对照组（P<0.05）。结论：抗精神病治疗能有效提高老年T2DM患者血糖控制效果，减轻其炎症反应与精神障碍症状，提高患者生活质量，值得临床推广。

Abstract:

Objective: To investigate the effect of type 2 diabetes mellitus (T2DM) on antipsychotic treatment of mental disorders. Methods: A total of 94 elderly patients with T2DM and mental disorders admitted to our hospital from March 2016 to February 2018 were randomly divided into the control group(47 cases) and the treatment group(47 cases). The control group was given only symptomatic treatment of T2DM, and the treatment group was treated with antipsychotic drugs. Blood glucose, interleukin-6(IL-6), tumor necrosis factor-α(TNF-α), brain-derived neurotrophic factor (BDNF) levels, simple mental illness scale(BPRS) and short form 36 item health survey were compared before and after treatment. Results: The scores of FBG, 2hPG, HbAlc, IL-6, TNF-α, BDNF, BPRS and short form SF-36 item health survey were not significantly different before treatment(P>0.05). After treatment, 2hPG The HbAlc, IL-6, TNF-α, level and BPRS scores in the treatment group were significantly lower than those in the control group. The BDNF level and short form 36 item health survey scores in the treatment group were significantly higher than those in the control group,(P<0.05).Conclusion: Antipsychotic treatment can effectively improve the blood sugar control effect of elderly patients with T2DM, reducing the symptoms of inflammatory reaction and mental disorder, improving the quality of life of patients, and is worthy of clinical promotion.

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备注/Memo

备注/Memo:

作者简介 和西波（1978-），男，副主任医师，硕士在读，研究方向：精神病与精神卫生学；通信作者：毛富强，E-mail: maofq@tmu.edu.cn。

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更新日期/Last Update: 2020-01-20