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《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:

25卷

期数:

2019年05期

页码:

459-462

栏目:

基础医学

出版日期:

2019-09-20

文章信息/Info

Title:

Intermittent hypoxia intervention improves cardiac function and exercise tolerance of rats with myocardial infarction

文章编号:

1006-8147(2019)05-0459-04

作者:

徐凯月; 孟祥雪; 黄 传; 史 昱; 万春晓

（天津医科大学总医院康复医学科，天津300052）

Author(s):

XU Kai-yue;  MENG Xiang-xue;  HUANG Chuan;  SHI Yu;  WAN Chun-xiao

（Department of Physical and Rehabilitation Medicine, General Hospital, Tianjin Medical University, Tianjin 300052, China）

关键词:

间歇性低氧; 心肌梗死; 心功能; 运动耐量; AMPK

Keywords:

intermittent hypoxia;  myocardial infarction;  cardiac function;  exercise tolerance;  AMPK

分类号:

R54

DOI:

-

文献标志码:

A

摘要:

目的：观察4周间歇性低氧（IH）干预对心梗（MI）大鼠心功能及运动耐量的影响。方法：28只雄性SD大鼠随机分为4组：空白组（Sham）、空白低氧组（Sham-IH）、心梗组（MI）和心梗低氧组（MI-IH）。低氧组放入低氧仓（模拟海拔5 000 m，氧浓度13%），每天4 h。对照组置于常氧环境中。干预4周后检测心肌AMPK表达，心梗面积比例，左心室射血分数和运动耐量。结果：同MI组比较，MI-IH组 （1） 心梗面积比例减少（P<0.001）；（2） 左心室射血分数增加（P<0.001）；（3） 运动耐量增加（P<0.001）；（4） AMPK表达增加（P<0.05）。结论：4周间歇性低氧干预能提高心功能和运动耐量，可能与心肌AMPK表达增加有关。

Abstract:

Objective: To explore the effects of four-week intermittent hypoxia (IH) intervention on cardiac function and exercise tolerance in rats with myocardial infarction (MI). Methods: Twenty-eight male SD rats were randomly divided into four groups: Sham group, Sham-IH group, MI group and MI-IH group. The IH groups were placed in the hypoxic chamber (simulates 5 000 maltitude, 13% oxygen concentration), at 4 h/d. The control groups were placed in normal environment. The AMPK expression, infarct size ratio, left ventricular ejection fraction and exercise tolerance were measured after 4-week intervention. Results: Compared with MI group, MI-IH group showed (1) decreased infarct size ratio (P <0.001)；(2) increased left ventricular ejection fraction(P <0.001)；(3) increased the exercise tolerance (P <0.001)；(4) increased the expression of AMPK(P <0.05). Conclusion: 4-week IH intervention can improve cardiac function and exercise tolerance in rats with MI, which may be related to AMPK elevation.

参考文献/References:

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备注/Memo

备注/Memo:

基金项目 天津市卫生局2016年重点发展项目（16KJ122），天津市自然科学基金重点项目（18JCZDJC98900）
作者简介 徐凯月（1994-），女，硕士在读，研究方向：心脏康复；通信作者：万春晓，E-mail：wcx2226@163.com。

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更新日期/Last Update: 2019-10-11