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[1]曹 颖,刘 娇,张云山.扳机日血清孕酮升高在不同卵巢反应人群中与优胚率的相关性分析[J].天津医科大学学报,2019,25(04):385-390.
 CAO Ying,LIU Jiao,ZHANG Yun-shan.Correlation analysis between serum progesterone elevation and the rate of excellent embryos in different ovarian response populations[J].Journal of Tianjin Medical University,2019,25(04):385-390.
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扳机日血清孕酮升高在不同卵巢反应人群中与优胚率的相关性分析(PDF)
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《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:
25卷
期数:
2019年04期
页码:
385-390
栏目:
临床医学
出版日期:
2019-07-20

文章信息/Info

Title:
Correlation analysis between serum progesterone elevation and the rate of excellent embryos in different ovarian response populations
文章编号:
1006-8147(2019)04-0385-06
作者:
曹 颖1刘 娇1张云山2
(1.天津医科大学研究生院,天津300070;2.天津市中心妇产科医院生殖医学中心,天津300100)
Author(s):
CAO Ying1 LIU Jiao1 ZHANG Yun-shan2
(1. Graduate School, Tianjin Medical University, Tianjin 300070, China; 2. Reproductive Medicine Center, Tianjin Central Hospital of Obstetrics and Gynecology, Tianjin 300100, China)
关键词:
血清孕酮长方案优胚率卵巢反应性
Keywords:
serum progesterone long protocol the rate of excellent embryos ovarian response
分类号:
R711.6
DOI:
-
文献标志码:
A
摘要:
目的:探讨在促性腺激素释放激素激动剂(GnRH-a)长方案的体外受精(IVF)周期中,人绒毛膜促性腺激素(hCG)扳机日血清孕酮水平在不同卵巢反应人群中与优胚率的关系。方法:回顾性分析纳入研究的5 097例患者,并根据卵巢反应性分成卵巢正常反应组和卵巢高反应组。每组均采用单因素线性回归分析与优胚率有关的参数,选择有统计学意义的因素进一步多因素线性回归分析,计算各参数的相关系数及95%置信区间。将孕酮水平以固定间隔分组,利用非参数检验比较组间优胚率的差异。结果:年龄、体质量指数(BMI)、不孕时间等与优胚率无关(P>0.05),而促性腺激素(Gn)用量、扳机日血清孕酮值和受精率与优胚率相关(P<0.01)。卵巢正常反应组和卵巢高反应组优胚率显著下降时的血清孕酮阈值浓度分别为1.5、1.8 ng/mL。结论:hCG扳机日孕酮升高对优胚率有不利影响,且血清孕酮阈值与卵巢反应性有关。
Abstract:
Objective: To explore the association between progesterone levels on the day of human chorionic gonadotrophin(hCG) administration and the rate of excellent embryos in different ovarian responsers in in vitro Fertilization(IVF)cycles with long gonadotropin-releasing hormone agonist(GnRH-a) protocol. Methods: Retrospective analysis was performed on 5 097 patients enrolled in the study who were divided into normal ovarian response group and high ovarian response group based on ovarian reponse. In each group, univariate linear regression analysis was used to analyze the parameters related to excellent embryo rate, and statistically significant factors were selected for further multivariate linear regression analysis to calculate the correlation coefficient and 95% confidence interval for each parameter. The progesterone levels were grouped at regular intervals and the differences in the rate of excellent embryos between the groups were compared using the nonparametric test. Results: Age, body mass index(BMI), infertility time and so on were not related to the rate of excellent embryos (P>0.05), while the amount of gonadotropin (Gn), serum progesterone value on the day of hCG administration and fertilization rate were correlated with the rate of excellent embryos(P<0.01). The serum progesterone threshold concentrations for the intermediate ovarian responder group and the high ovarian responder group were significantly decreased from 1.5 ng/mL and 1.8 ng/mL, respectively. Conclusion: Increased progesterone levels on the day of hCG administration may have a negative effect on the rate of excellent embryos, and serum progesterone threshold concentration may be associated with ovarian responses.

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备注/Memo

备注/Memo:
作者简介 曹颖(1993-),男,医师,硕士在读,研究方向:生殖医学;通信作者:张云山,E-mail:tjzys@hotmail.com。
更新日期/Last Update: 2019-08-28