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《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:

25卷

期数:

2019年04期

页码:

382-384390

栏目:

临床医学

出版日期:

2019-07-20

文章信息/Info

Title:

Effects of different GnRH-analogue on polycystic ovarian syndrome with LH/FSH ratioof 2 or higher

文章编号:

1006-8147(2019)04-0382-03

作者:

刘 娇¹; 罗海宁²; 韩 莹²; 曹 颖¹; 张云山²

（1.天津医科大学研究生院，天津300070； 2.天津市中心妇产科医院生殖医学中心，天津300100）

Author(s):

LIU Jiao¹;  LUO Hai-ning²;  HAN Ying²;  CAO Ying¹;  ZHANG Run-shan²

(1. Graduate School, Tianjin Medical University, Tianjin 300070, China; 2. Reproductive Medicine Cencer, Tianjin Central Hospital of obstetrics and Gynecology, Tianjin, 300100, China)

关键词:

多囊卵巢综合征; LH/FSH; GnRH拮抗剂方案; GnRH激动剂长方案; 体外受精-胚胎移植

Keywords:

PCOS; LH/FSH; GnRH antagonist protocols; GnRH agonist long protocols;  in vitro fertilization and embryo transfer

分类号:

R711.6

DOI:

-

文献标志码:

A

摘要:

目的：探讨促性腺激素释放激素（GnRH）激动剂长方案与GnRH拮抗剂方案对LH/FSH比值大于等于2的多囊卵巢综合征（ PCOS）患者胎质量影响及助孕结局的差别。方法：回顾性分析本中心多囊卵巢综合征患者行体外受精-胚胎移植（IVF-ET），将月经第3天LH/FSH比值为2设为临界值分为比值升高组（58个周期）和比值未升高组（248个周期），分析比较两组基础临床资料，再分别根据不同促排卵方案分为GnRH激动剂长方案与GnRH拮抗剂方案组，根据LH/FSH的比值不同探讨不同促排卵方案对PCOS患者胚胎质量及妊娠结局的影响。结果：首次分组，LH/FSH≥2组Gn总量少于LH/FSH<2组（P<0.05），胚胎质量及临床结局无统计学差异（P>0.05）；再次分组，在LH/FSH≥2前提下应用GnRH拮抗剂方案组促性腺激素（Gn）总量、Gn总天数少于GnRH激动剂长方案组（P<0.05），获卵数、正常受精数、正常卵裂数、优胚数均优于GnRH激动剂长方案组（P<0.05）。结论：PCOS患者中月经第3天LH/FSH比值以2为临界值可能对胚胎质量及临床结局无显著影响，LH/FSH临界值≥2的PCOS患者应用GnRH拮抗剂方案临床结局明显优于GnRH激动剂长方案。

Abstract:

Objective: To explore the effect of different GnRH-analogue on the quality of embryos and the outcome of pregnancy in patients with polycystic ovary syndrome (PCOS) with LH/FSH ratio of 2 or higher. Methods： With the PCOS patients day-3 LH/FSH ratio of 2 as the critical value, the data of 58 cycles which ratio greater than or equal to 2 and the data of 248 cycles which ratio less than 2 were analyzed retrospectively. And then the subjects were again divided into GnRH antagonist protocol group and GnRH agonist protocol group according to different GnRH-analogue. In the light of the ratio of LH/FSH，the relationship between different GnRH-analogues and clinical outcome was discussed. Results：The total number of Gn in LH/FSH≥2 group was less than that in LH/FSH<2 group (P<0.05). There was no significant differences in embryo quality and clinical outcome； the length of stimulation and the dose of gonadotropin were significantly less in GnRH antagonist group than in GnRH agonist long protocol group under the premise of LH/FSH≥2(P<0.05)； the number of retrieval oocytes, normal-fertilized oocytes，normal-cleavage oocytes and high quality embryos were better than the GnRH agonist long protocol group (P>0.05). Conclusion: The day-3 LH/FSH ratio of PCOS patients with 2 as the critical value may not have significant effects on embryo quality and clinical outcomes, and the clinical outcomes of LH/FSH≥2 in patients with polycystic ovary syndrome GnRH antagonist scheme significantly outperforms the GnRH agonist long protocol.

参考文献/References:

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备注/Memo

备注/Memo:

作者简介 刘娇（1986-），女，主治医师，硕士在读，研究方向：生殖医学；通信作者：张云山，E-mail:tjzys@hotmail.com。

常用功能

更新日期/Last Update: 2019-08-28