|本期目录/Table of Contents|

[1]罗慧景,胡志东,田 原,等.天津6 085名健康成人静脉血细胞分析的参考区间调查[J].天津医科大学学报,2019,25(02):136-139.
　LUO Hui-jing,HU Zhi-dong,TIAN Yuan,et al.Investigation on venous blood cells reference intervals in 6085 healthy adults in Tianjin[J].Journal of Tianjin Medical University,2019,25(02):136-139.
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《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:
25卷
期数:
2019年02期
页码:
136-139
栏目:
临床医学
出版日期:
2019-03-20

文章信息/Info

Title:
Investigation on venous blood cells reference intervals in 6085 healthy adults in Tianjin
文章编号:
1006-8147(2019)02-0136-04
作者:
罗慧景; 胡志东; 田 原; 王 静; 彭瑞清; 张晓方; 罗 微
（天津医科大学总医院检验中心，天津300052）
Author(s):
LUO Hui-jing; HU Zhi-dong; TIAN Yuan; WANG Jing; PENG Rui-qing; ZHANG Xiao-fang; LUO Wei
（Clinical Laboratory Center, General Hospital, Tianjin Medical University, Tianjin 300052, China）
关键词:
健康成人; 血细胞; 参考区间
Keywords:
healthy adults; blood cells; reference intervals
分类号:
R446
DOI:
-
文献标志码:
A
摘要:
目的：调研天津地区健康成人静脉血细胞的参考区间，为建立可行、实用的血细胞参考区间提供数据支撑。方法：研究对象为在天津医科大学总医院健康管理中心进行体检的成年人，参照CLSI C28-A3文件的标准，排除血液病、甲状腺疾病和肾病等可能会影响血细胞参数的疾病，于清晨采集空腹静脉血，用日本sysmex XN9000血细胞分析仪及配套试剂在2 h内进行血细胞分析（包括WBC、RBC、Hb、PLT、HCT等参数），从采样到分析过程严格质量控制工作；采用统计软件包SAS 9.3对数据进行统计分析，实验结果与现行的国家行业标准及其它地区的参数进行比较。结果：本研究共筛选出6 085名健康体检者，年龄19~96岁，其中男2 853名，平均年龄44.2岁；女3 232名，平均年龄45.8岁。血细胞主要参数参考区间：WBC男（3.6~9.1）×109/L，女（3.3~8.8）×109/L，RBC男（3.6~5.9）×1012/L，女（3.9~5.2）×1012/L，PLT男（146~348）×109/L，女（158~371）×109/L，Hb男（139~176）g/L，女（117~153）g/L，HCT男（41~52）%，女（36~46）%；男性WBC、RBC、Hb和HCT均高于女性（P<0.05），而PLT小于女性（P<0.05），并且随着年龄增长，该5项参数均有下降趋势；本研究所得WBC较现用行业标准偏低，而RBC、Hb、PLT和HCT均较行业标准高。结论：本研究结果表明天津地区的血细胞分析参考区间与现行国家行业标准、其他地区有所差异，性别和年龄对血细胞参考区间有所影响，提示建立适合本地区的血细胞分析参考区间非常必要，并且注意性别和年龄组的差异。
Abstract:
Objective: To investigate the main reference intervals of venous blood cells in healthy adults in Tianjin and provide data support for establishing feasible and practical reference intervals of blood cells. Methods: Healthy subjects in Tianjin Medical University General Hospital-Health Management Centre were chosen. After excluding blood diseases, thyroid diseases, kidney diseases and other diseases, which may affect blood parameters according to CLSI C28-A3, we collected fasting venous blood and analyzed (including WBC, RBC, Hb, PLT, HCT and so on) by sysmex XN9000 with auxiliary reagents with in 2 hours. Quality control was implemented strictly during sampling and analysis. We did statistical analysis by statistical package SAS9.3 and compared the results with national standards and reference intervals in other regions of China. Results: In this study, 6 085 health adults were selected, ranging from 19 to 96 years old, including 2 853 males whose average age was 44.2 years old and 3 232 females whose average age was 45.8 years old. The main reference intervals of blood cells in this region: WBC male (3.6 ~ 9.1)×109/L, female (3.3~8.8)×109/L, RBC male (3.6~5.9)×1012 /L, female (3.9~5.2)×1012/L, PLT male (146~348)×109/L, female (158~371)×109/L, Hb male (139~176) g/L, female (117~153) g/L, HCT male (41~52)%, female (36~46)%. WBC, RBC, Hb and HCT were all higher in males than in females(P<0.05), while PLT was lower(P<0.05) and these five parameters all showed a downward trend as the age increased; WBC obtained in this study was lower than current national standards, while RBC, Hb, PLT and HCT were higher than national standards. Conclusions: The results of this study indicate that the reference intervals of blood cell analysis in Tianjin are different from current national standards and other regions, and that gender and age can influence the reference intervals, indicating that it is very necessary to establish blood cells analysis reference intervals for this region, meanwhile, the difference between gender and age is also important.

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备注/Memo

备注/Memo:
基金项目 国家青年自然科学基金资助项目（81701968） 作者简介 罗慧景（1990-），女，硕士在读，研究方向：临床检验与诊断；通信作者：张晓芳，E-mail: xiaofangz1986@163.com； 罗微，E-mail: 115049520@qq.com。
更新日期/Last Update: 2019-04-25