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《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:

24卷

期数:

2018年06期

页码:

545-548

栏目:

临床医学

出版日期:

2018-11-20

文章信息/Info

Title:

Changes in meibomian glands morphology and function and its effect on ocular surface in patients with type 2 diabetes

作者:

梁伟彦¹; 2; 赵少贞³

（1.天津医科大学研究生院，天津300070；2.天津爱尔眼科医院综合科，天津300384，3.天津医科大学眼科医院屈光与屈光与角膜病科，天津300384）

Author(s):

LIANG Wei-yan¹; 2; ZHAO Shao-zhen³

（1. Graduate School, Tianjin Medical University，Tianjin 300070，China; 2. Department of General, Tianjin Aier Eye Hospital，Tianjin 300384，China；3. Department of Refraction and Corneal Disease, Tianjin Medical University Eye Hospital， Tianjin 300384，China）

关键词:

2型糖尿病; 睑板腺; 眼表; 眼表综合分析仪

Keywords:

type 2 diabetes; meibomian glands;  ocular surface; keratograph 5M

分类号:

R777.1+3

DOI:

-

文献标志码:

A

摘要:

目的：探讨2型糖尿病患者睑板腺形态与功能的改变及其对眼表的影响。方法：收集自2016年9月-2017年9月就诊于我院门诊已确诊的2型糖尿病患者128例作为试验组，于同一时间段在我院就诊的白内障患者130例作为对照组，分别比较试验组与对照组间的眼表症状评分、非侵入式泪膜破裂时间、睑板腺缺失面积评分分级、睑板腺开口堵塞程度评分及睑板腺分泌物性状评分。结果：试验组患者OSDI评分为（25.12±12.24），明显高于对照组（11.12±8.48），差异有统计学意义（Z=-6.018，P<0.001）；试验组NI-BUT（3.86±2.60 s）明显短于对照组（8.96±4.74 s），差异具有统计学意义（Z=-7.632，P<0.001）；试验组中59.37%的患者存在睑板腺缺失，明显多于对照组38.46%；试验组患者睑板腺缺失面积评分明显高于对照组，差异具有统计学意义（Z=-3.865，P<0.001）；睑板腺开口堵塞评分试验组（1.89±0.87）明显高于对照组（0.84±0.72），差异均具有统计学意义（Z=-8.413，P<0.001)。试验组睑板腺分泌物评分为（1.46±0.68），明显高于对照组（0.82±0.63），差异具有统计学意义（Z=-8.761，P<0.001）。结论：2型糖尿病患者出现眼表功能改变及眼部不适症状的概率远远高于非糖尿病人群，且与非糖尿病患者相比，糖尿病患者中干眼的症状程度较重，睑板腺形态及功能出现异常的比例以及异常的程度也较非糖尿病患者明显升高。

Abstract:

Objective: To investigate the changes of morphology and function of meibomian glands in type 2 diabetic patients and its influence on ocular surface. Methods: A total of 128 type 2 diabetic patients diagnosed in our hospital from September 2016 to September 2017 were selected as the trial group. One-hundred of thirty cataract patients treated in our hospital during the same period were served as the control group. The ocular symptom scores, noninvasive tear film break-up time, meibomian glands loss area grading, meibomian glands opening blockage score and meibomian glands secretion trait scores were compared between the trial group and the control group respectively. Results: The Ocular Surface Disease Index（OSDI）score of the trial group was （25.12 ± 12.24）， which was significantly higher than that of the control group （11.12 ± 8.48）, and the difference was statistically significant （Z = -6.018，P <0.001）；ｔhe noninvasive tear film break-up time was significantly shorter than that of the control group （8.96 ± 4.74ｓ）（Z=-7.632，P<0.001). The meibomian glands loss in 59.37% of the patients in the trial group was significantly higher than that in the control group （38.46% （Z = -3.865, P <0.001）. Meibomian glands opening blockage score of trial group （1.89 ± 0.87） was significantly higher than that of the control group （0.84 ± 0.72）. The differences were statistically significant （Z = -8.413，P <0.001）. Meibomian glands secretion score （1.46 ± 0.68） in the trial group was also significantly higher than that in the control group （0.82 ± 0.63）, and the difference was statistically significant （Z = -8.761，P<0.001）. Conclusion: The incidence of ocular surface dysfunction and eye discomfort in patients with type 2 diabetes is much higher than that in non-diabetic people, and the severity of dry eye in diabetic patients is greater than that in non-diabetic patients. The meibomian glands morphology and dysfunctional proportions. And the degree of abnormalities is also significantly higher than non-diabetic patients.

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备注/Memo

备注/Memo:

作者简介 梁伟彦（1987-），女，硕士在读，研究方向：眼科学；通信作者：赵少贞，E-mail：zhaosz1997@sina.com。

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更新日期/Last Update: 2018-11-30