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《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:

24卷

期数:

2018年03期

页码:

224-225,228

栏目:

出版日期:

2018-05-20

文章信息/Info

Title:

Value of random urinary albumin to creatinine ratio for early diagnosis of type 2 diabetic nephropathy

作者:

刘建广¹; 王新²

1. 天津医科大学代谢病医院检验科，天津 300070；2. 天津医科大学总医院麻醉科，天津市麻醉学研究所，天津 300052

Author(s):

LIU Jian-guang¹;  WANG Xin²

1. Department of Clinical Laboratory, Metabolic Diseases Hospital, Tianjin Medical University, Tianjin 300070, China；2. Department of Anesthesiology, General Hospital, Tianjin Medical University, Tianjin Research Institute of Anesthesiology, Tianjin 300052, China

关键词:

尿微量白蛋白与肌酐比值; 糖尿病肾病; 医学决定水平

Keywords:

ACR;  diabetic nephropathy;  medical decision level

分类号:

R587.1

DOI:

-

文献标志码:

A

摘要:

目的：探讨随机尿微量白蛋白与肌酐比值在2型糖尿病早期肾损伤诊断中的临床应用价值。方法：以459例2型糖尿病患者及97例健康体检者为研究对象，采用速率散射比浊法测定随机尿中微量白蛋白（mALB）和肌酐（Cr）含量，并计算mALB与Cr的比值（ACR）。与24 h微量尿白蛋白定量结果进行线性回归分析，确定其相关性。以尿白蛋白排泄率>20 mg/24 h为诊断标准，计算ACR诊断糖尿病肾病的特异性和灵敏度，并初步确定其医学决定水平。结果：随机尿ACR与24 h尿微量白蛋白定量值相关性分析 r =0.738（P <0.01）呈正相关，具有统计学意义，ACR的医学决定水平为2.285 mg/mmol。结论：ACR高于2.285 mg/mmol时，提示医生进行早期干预治疗。

Abstract:

Objective: To investigate the value of urinary albumin to creatinine ratio（ACR） for early diagnosis of type 2 diabetic nephropathy. Methods: The microalbumin (mALB) and creatinine (Cr) content in random urine of 459 type 2 diabetic patients nephropathy and 97 healthy people was detected through immunoturbidimetric assay, and the ratio of mALB to Cr (ACR) was determined. Linear regression analysis was used to determine the correlation between the results of ACR and urine persistant mALB. Urinary protein excretion rate >20 mg/min was set as the diagnostic criteria to calculate the specificity and sensitivity of ACR in the diagnosis of diabetic nephropathy, and the medical decision level was preliminarily determined. Results: The correlation analysis between random urine ACR and 24 h urine albumin showed a positive correlation between them, with statistical significance[r =0.738 (P <0.01)] , and the medical decision level of ACR was 2.285 (mg/mmol). Conclusion: When ACR is higher than 2.285 (mg/mmol), doctors should perform early intervention.

参考文献/References:

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[4] Weir M R. Microalbuminuria in type 2 diabetics: an important, overlooked cardiovascular risk factor[J]. J Clin Hypertens (Greenwich), 2004,6(3):134
[5] 蔡文娟,李洋,门岚,等.尿微量白蛋白/肌酐比值对糖尿病肾病早期诊断价值[J]. 中国实验诊断学,2013,17（9）:1650
[6] Cundy T, Baker J. Prediction of albumin excretion rate from albumin-to-creatinine ratio[J]. Diabetes Care, 2000,23(5):714
[7] Gross J L, Zelmanovitz T, Oliveira J, et al. Screening for diabetic nephropathy: is measurement of urinary albumin-to-creatinine ratio worthwhile[J]. Diabetes Care,1999,22(9):1599
[8] 何向东.医学决定水平概述[J].实用医技杂志,2013,20（2）:160
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备注/Memo

备注/Memo:

文章编号 1006-8147(2018)03-0224-02
基金项目 天津医科大学代谢病医院内分泌研究所科学基金（2012DX07）
作者简介 刘建广(1987-),男,检验技师,学士,研究方向:糖尿病肾病早期诊断；通信作者：王新，E-mail: wangxin19880503@163.com。

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更新日期/Last Update: 2018-05-20