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《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:

22卷

期数:

2016年05期

页码:

430-433

栏目:

临床医学

出版日期:

2016-09-20

文章信息/Info

Title:

Correlation? between the frequency of spontaneous abortion and chromosome abnoemality in couples with spontaneous abortion

文章编号:

1006-8147（2016）05-0430-4

作者:

刘蓝泽; 张 娜; 李 岩; 史云芳; 李晓洲; 琚 端; 张 颖

(天津医科大学总医院妇产科遗传室,天津300052)

Author(s):

LIU Lan-ze;  ZHANG Na;  LI Yan;  SHI Yun-fang;  LI Xiao-zhou;  JU Duan ;  ZHANG Ying

(Department of Obstetrics and Gynecology, General Hospital ,Tianjin Medical University, Tianjin 300052, China)

关键词:

自然流产; 染色体核型 ; 第三代试管婴儿

Keywords:

spontaneous abortion ;  chromosome karyotype;  preimplantation genetic diagnosis

分类号:

R394

DOI:

-

文献标志码:

A

摘要:

目的： 探讨自然流产次数与自然流产夫妇染色体异常的关系。方法 ：收集因自然流产进行染色体检查的1 784对夫妇的基本信息，其中1次流产者663对，2次流产者869对，≥3次者252对，行外周血染色体分析。结果： 1次流产组检出染色体异常夫妇27对，异常率为4.07%(27/663)；2次流产组检出31对，异常率3.57%(31/869)；≥3次组检出18对，异常率7.14%(18/252)，比较不同流产次数组染色体异常构成比，无显著性差异 (χ?分别为0.252、3.639、5.922，p均>0.05)；1 784对（3 568例）自然流产夫妇中共发现染色体异常核型77例，占2.16%（77/3 568），其中结构异常49例，占异常核型的63.64%(49/77)，数目异常28例，占异常核型的36.36%(28/77)，且结构异常多于数目异常，差异有统计学意义(χ?=5.79，p<0.05)。结论： 自然流产次数与夫妇双方染色体异常之间无相关性，建议在1次自然流产后即行夫妇双方染色体检测。

Abstract:

Objective ：To investigate the relationship between the frequency of spontaneous abortion and the chromosome abnormality of the couples, and discuss the appropriate frequency to detect chromosome. To provide experimental data for genetic counseling , prenatal diagnosis and the selection of conception mode in couples with abnormal chromosome. Methods： The information of 1 784 couples with the history of spontaneous abortion were collected and the chromosome from peripheral blood of this couples was detected jiashang. Six hundred and sixty-three couples experienced spontaneous abortion once. Eight hundred and sixty-nice couples experienced spontaneous abortion twice. Two hundred and fifty-two couples experienced spontaneous abortion 3 times or more. Results： In the group of the couples who had experienced spontaneous abortion once, 27 couples showed abnormal karyotypes , accounting for 4.07%(27/663). In the group of the couples who had experienced spontaneous abortion twice, 31 couples were observed with abnormal karyotypes, accounting for 3.57%(31/869). In the group of the couples who had experienced spontaneous abortion three times or more, 18 couples had chromosome abnormality, accounting for 7.14%(18/252).Statistical analysis was carried out on the chromosome abnormality rates among the three groups. Difference is not significant(χ?=0.252，3.639，5.922, P> 0.05). In 1 784 couples, we found 77 cases of abnormal karyotype, accounting for 2.16% (77/3 568) of all patient, with 49 cases of structural abnormalities and 28 cases of numerical abnormalities, accounting for 63.64%(49/77) and 36.36%(28/77),respectively. Conclusion ：There is no correlation between the frequency of spontaneous abortion and the chromosome abnormality. If possible, the couples who have experienced spontaneous abortion once should have chromosome(test+).