|本期目录/Table of Contents|

[1]程婷婷,王凤梅,朱争艳,等.HBV慢性感染者肝脏组织中CD4+T、CD8+T和FoxP3+Tregs细胞的表达水平[J].天津医科大学学报,2016,22(02):129-132.
　CHENG Ting-ting,WANG Feng-mei,ZHU Zheng-yan,et al.Level of CD4+T、CD8+T and FoxP3+Tregs in the liver tissues of patients with chronic HBV infection[J].Journal of Tianjin Medical University,2016,22(02):129-132.
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《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:
22卷
期数:
2016年02期
页码:
129-132
栏目:
临床医学
出版日期:
2016-03-20

文章信息/Info

Title:
Level of CD4+T、CD8+T and FoxP3+Tregs in the liver tissues of patients with chronic HBV infection
文章编号:
1006-8147（2016）02-0129-04
作者:
程婷婷1; 2; 王凤梅2; 朱争艳3; 刘 辉3; 吕洪敏2
（1.天津医科大学第三中心临床学院消化(肝病)科，天津 300170；2.天津市第三中心医院消化(肝病)科，天津 300170；3.天津市肝胆疾病研究所，天津市人工细胞重点实验室，天津 300170）
Author(s):
CHENG Ting-ting1; 2;  WANG Feng-mei2;  ZHU Zheng-yan3;  LIU Hui3;  LV Hong-min2
(1. Department of Gastroenterology and Hepatology, The Third Central Clinical College ， Tianjin Medical University, Tianjin 300170, China; 2. Department of Gastroenterology and Hepatology, The Third Central Hospital of Tianjin, Tianjin 300170, China; 3.Key Laboratory of Artificial Cell, Institute of Hepatobiliary Disease, Tianjin 300170,China )
关键词:
乙型肝炎病毒; CD4+T细胞; CD8+T细胞; FoxP3+Tregs细胞;  肝脏
Keywords:
hepatitis B virus;  CD4+ T cells;  CD8+ T cells;  FoxP3+T cells;  liver
分类号:
R512.6+2
DOI:
-
文献标志码:
A
摘要:
?目的：计数慢性乙型肝炎病毒( HBV)感染者肝脏组织中CD4+T、CD8+T和FoxP3+Tregs细胞，观察不同免疫状态下的肝脏组织中CD4+T和CD8+T细胞表达水平之间的差异，探索其临床意义。方法: 选取慢性HBV感染者68例，健康对照组(非HBV感染组)30例，运用免疫组织化学的方法进行检测。结果：慢性HBV感染组的CD4+T、CD8+T和FoxP3+Tregs细胞表达水平明显升高，与非HBV感染组相比，P均<0.001；在HBV感染组中，CD4+T和CD8+T细胞在免疫耐受期患者肝脏组织中的表达水平最低，CD4+T、CD8+T细胞在免疫清除期、再活动期中的表达水平与二者在免疫耐受期相比，均有增高趋势，然而CD4+T、CD8+T细胞的表达水平在免疫耐受期、免疫清除期、低复制期及再活动期任意两期之间比较，P均>0.05。结论：CD4+T和CD8+T细胞在免疫耐受期、免疫清除期、低复制期及再活动期患者肝脏组织中表达水平的变化趋势在一定程度上反应了各期肝脏的免疫状态；FoxP3+ Tregs细胞可能与HBV感染慢性化有关。
Abstract:
Objective: To count the number of CD4+T, CD8+T and FoxP3+Tregs in the liver tissue of patients with chronic HBV infection and compare the expression levels of CD4+T and CD8+T cells in liver tissues in different immune status. Methods: The levels of CD4+T, CD8+T and FoxP3+Tregs were detected by the method of immunohistochemistry in 68 chronic HBV infection patients, and 30 individuals without HBV infection as healthy control. Results: Compared with the non-HBV infection group, the expression level of CD4+T, CD8+T and FoxP3+Tregs were significantly higher in the chronic HBV infection group (P<0.001); In chronic HBV infection group, the numbers of CD4+T and CD8+T in immune clearance and active period were higher than the ones in the immune tolerance, and the liver tissue from immune tolerance patients had lowest CD4+T and CD8+T levels, but P>0.05 respectively. Conclusion: To some extent, the expression levels of CD4+T and CD8+T cells in the immune tolerance, immune clearance phase, low copy phase and active period indicate the liver immune status; and maybe FoxP3+ Tregs are associated with chronic HBV infection.

参考文献/References:

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备注/Memo

备注/Memo:
基金项目 天津市应用基础与前沿技术研究计划(13JCYBJC22500)，天津市卫生局科技基金(2010KZ123)

作者简介 程婷婷( 1987-)，女，硕士在读，研究方向：肝脏相关疾病；通信作者: 吕洪敏，E-mail: lvhongmin58@163.com。



更新日期/Last Update: 2016-03-23