|本期目录/Table of Contents|

[1]胡善雷,李广明,任 娜,等.GP73在HBV相关性肝病中的水平及意义[J].天津医科大学学报,2019,25(06):615-617.
 HU Shan-lei,LI Guang-ming,REN Na,et al.The level and significance of GP73 in HBV related liver diseases[J].Journal of Tianjin Medical University,2019,25(06):615-617.
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《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:
25
期数:
2019年06期
页码:
615-617
栏目:
临床医学
出版日期:
2019-11-20

文章信息/Info

Title:
The level and significance of GP73 in HBV related liver diseases
文章编号:
1006-8147(2019)06-0615-03
作者:
胡善雷李广明任 娜许金生高 鹏李 琤
(郑州市第六人民医院肝病科,郑州 450000)
Author(s):
HU Shan-leiLI Guang-ming REN NaXU Jing-shengGAO PengLI Zheng
(Depratment of Hepatology ,The Sixth People’s Hospital of Zhengzhou,Zhengzhou 450000,China)
关键词:
高尔基体蛋白73乙型肝炎病毒肝癌肝硬化
Keywords:
Golgi protein 73hepatitis B virusliver cancercirrhosis
分类号:
R575
DOI:
-
文献标志码:
A
摘要:
目的:探讨高尔基体蛋白73(GP73)在乙型肝炎病毒(HBV)相关性肝病中的检测及意义。方法:选取2016年5月-2018年5月在我院治疗的HBV相关性肝病患者160例,其中慢性乙肝患者78例,乙肝肝硬化患者52例,肝癌患者30例,采用GP73检测试剂盒检测血清GP73水平。结果:肝癌组、乙肝肝硬化组和慢性乙肝组血清GP73分别为(101.11±35.60)ng/mL、(81.87±30.54)ng/mL和(60.45±12.24)ng/mL,肝癌组>乙肝肝硬化组>慢性乙肝组>对照组(P<0.05);丙氨酸氨基转移酶(ALT)、天门冬氨酸转氨酶(AST)和总胆红素(TBIL)水平,肝癌组>乙肝肝硬化组>慢性乙肝组>对照组(P<0.05),而ALB水平,肝癌组<乙肝肝硬化组<慢性乙肝组<对照组(P<0.05);血清GP73与ALT、AST、TBIL成正相关(r=0.451、0.406和0.357,P<0.05),与ALB成负相关(r=-0.380,P<0.05)。结论: GP73在HBV相关性肝病中明显升高,与疾病严重程度和肝功能有一定关系。
Abstract:
Objective: To investigate the detection and significance of Golgi protein 73 (GP73) in hepatitis B virus (HBV) related liver diseases. Methods: From May 2016 to May 2018,160 patients with HBV-related liver diseases were selected, including 78 patients with chronic hepatitis B, 52 patients with cirrhosis of hepatitis B and 30 patients with hepatocellular carcinoma, the serum GP73 level was detected by GP73 test kit. Results: The serum GP73 levels in hepatocellular carcinoma group, hepatitis B cirrhosis group and chronic hepatitis B group were (101.11±35.60) ng/mL, (81.87±30.54) ng/mL and (60.45±12.24) ng/mL, the serum GP73 levels in hepatocellular carcinoma group> hepatitis B cirrhosis group>chronic hepatitis B group>control group (P<0.05);alanineaminotransferase(ALT),aspartate aminotransferase (AST) and tumor bilirubin(TBIL) in hepatocellular carcinoma group>hepatitis B cirrhosis group>chronic hepatitis B group>control group (P<0.05), and ALB in hepatocellular carcinoma group<hepatitis B cirrhosis group<chronic hepatitis B group<control group (P<0.05); serum GP73 were positively correlated with ALT, AST and TBIL (r=0.451, 0.406 and 0.357, P<0.05), and negatively correlated with ALB (r=-0.380, P<0.05). Conclusion: GP73 are increased significantly in HBV related liver diseases, which are related to the severity of disease and liver function.

参考文献/References:

[1] 乐萍,高国生,董飞波,等.血清高尔基体蛋白73及3种评分系统对慢性乙型肝炎患者肝纤维化的预测价值研究[J].中华医院感染学杂志,2016,26(11):2529
[2] 黄风玲,杨颖,张瑞丽,等.肝细胞癌组织中高尔基体蛋白73和转化生长因子β1及Smad2的表达水平及其意义[J].中国全科医学,2016,19(26):3191
[3] 赵年,李春华,李德秀,等.MRI与CT多期动态增强扫描诊断肝硬化伴肝癌的效果比较[J].中国CT和MRI杂志,2017,15(5):85
[4] 罗晓云,胡仁静,武标,等.高尔基体蛋白73在早期肝癌中诊断价值[J].中国现代医学杂志,2016,26(21):100
[5] 应盛,高国生,董飞波,等.血清GP73对慢加急性肝衰竭患者短期预后的评价[J].中华医院感染学杂志,2016,26(21):4894
[6] 赵殊棋,石统东.聚乙二醇-干扰素治疗慢性乙型肝炎患者应答预测因素研究进展[J].现代医药卫生,2016,13(4):527
[7] 李海燕.乙肝HBx蛋白上调CD147介导肝纤维化的调控机制研究[D].西安:第四军医大学,2016
[8] 郝磊,郝坤.血清AFP,AFU,CEA,GP73及糖链抗原系列联合检测对于早期原发性肝癌的诊断价值[J]. 实用癌症杂志,2017,32(10):1609
[9] Bookstaver P B,Foster J L,Lu Z K, et al.Hepatitis B virus seroconversion rates among health sciences students in the southeastern United States[J]. J Am Coll Health,2016,64(1):69
[10] 张小曼,魏梅娟,许正锯,等.血清甲胎蛋白,白细胞介素-6和高尔基体蛋白73在肝脏疾病中的表达特点及其对肝细胞癌的诊断价值[J].中华实验和临床感染病杂志,2017,11(4):339
[11] Xu Z J,Shen J K,Pan X N, et al.Predictive value of serum Golgi protein 73 for prominent hepatic necroinflammation in chronic HBV infection[J]. J Med Virol,2018,90(6):1053
[12] 和海玉,路明亮,黄华,等. GP73在慢性乙型肝炎、肝硬化、原发性肝癌血清及组织中的表达[J]. 昆明医科大学学报,2016,37(4):41
[13] Cao Z J,Li Z Q,Wang H, et al. Algorithm of golgi protein 73 and liver stiffness accurately diagnoses significant fibrosis in chronic HBV infection[J]. Liver International,2017,37(11):1612
[14] 徐凤玲,吕江峰,庄伟,等.病毒性肝炎临床检测指标的诊断分析[J].中华医院感染学杂志,2016,26(19):4362
[15] 余敏,王立坤.干扰素联合核苷类药物对乙肝患者外周血T淋巴细胞亚群表达改变的相关性研究[J]. 中国临床药理学杂志,2016, 32(5):415

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备注/Memo

备注/Memo:
基金项目 郑州市科技计划重大项目基金资助(152PZDZX035)
作者简介 胡善雷(1983-),男,主治医师,硕士,研究方向:肝脏疾病;通信作者:李广明,E-mail:ta80mu@163.com。
更新日期/Last Update: 2020-01-20