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《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:

22卷

期数:

2016年02期

页码:

107-110

栏目:

专题报道

出版日期:

2016-03-20

文章信息/Info

Title:

Impact of 1ipoprotein-associated phospholipase A2 on adverse cardiovascular events in hospitalized patients with acute myocardial infarction

文章编号:

1006-8147（2016）02-0107-04

作者:

宋温婷; 李 秀; 王丹丹; 郭星梅; 刘相丽

(天津医科大学第二医院心脏科,天津 300211)

Author(s):

SONG Wen-ting ;  LI Xiu ; WANG Dan-dan ;  GUO Xing-mei LIU Xiang-li

(Department of Cardiology,The Second Hospital, Tianjin Medical University,Tianjin 300211,China)

关键词:

急性心肌梗死; 脂蛋白相关磷脂酶A2;  不良心血管事件

Keywords:

acute myocardial infarction;  lipoprotein-associated phospholipase A2 ;  major adverse cardiovascular events

分类号:

R542.2+2

DOI:

-

文献标志码:

A

摘要:

目的:探讨血浆脂蛋白相关磷脂酶A2（Lp-PLA2）对急性心肌梗死（AMI）患者在住院期间发生不良心血管事件的影响。方法: 收集明确诊断为AMI的住院患者167例，依据ST段抬高与否分为ST段抬高型心肌梗死STEMI组（86例)及非ST段抬高型心肌梗死NSTEMI组（81例），同时收集非急性心肌梗死80例作为对照组，记录在院期间的主要不良心血管事件(包括心源性死亡、再发心肌梗死、心力衰竭、恶性心律失常、反复缺血性心绞痛发作等)。比较３组患者血浆Lp-PLA2水平并分析血浆Lp-PLA2水平与患者在住院期间发生不良心血管事件的相关性。结果：（1）AMI患者Lp-PLA2水平高于对照组，且在STEMI组升高最明显，组间比较差异有统计学意义，P<0.05；（2）心血管事件发生率随着Lp-PLA2水平的升高而呈明显上升趋势，P<0.05；（3）AMI患者中不良事件发生组Lp-PLA2水平显著高于无不良事件发生组的患者[（288.732±124.873） ng/ mL对（231.537±92.059） ng/ mL]，P<0.05；（4）经Logistic回归分析发现Lp-PLA2水平是影响AMI患者院内心血管事件发生率的一个独立危险因素，P<0.05；结论：Lp-PLA2对AMI患者院内不良心血管事件的发生有一定的预测价值，检测血浆Lp-PLA2水平可优化AMI患者院内风险评估。

Abstract:

Objective: To determine the prognostic utility of lipoprotein -associated phospholipase A2 (Lp-PLA2) for in-hospital major adverse cardiovascular events （MACE） in patients with acute myocardial infarction(AMI)； Methods: A total of 167 patients referred for AMI participated, including 86 patients who were diagnosed as ST-segment elevation Acute Myocardial Infarction (STEMI) and 81 patients without ST-elevation (non-STEMI)) ,while 80 patients without AMI were selected as the control group; The following in-hospital MACE were recorded: death , remyocardial infarction , angina pectoris after MI , acute heart failure, and life threatening arrhythmias. The Lp-PLA2 levels among each group were compared, and the correlation between in-hospital MACE and Lp-PLA2 levels was explored. Results: (1)The plasma concentration of Lp-PLA2 was higher in patients with AMI than those of the control group, and the（加上） STEMI group was the highest, P<0.05; （2）The occurrence rate of in-hospital MACE rose was elevated significantly with the increased level of Lp-PLA2, P<0.05；(3) Levels of Lp-PLA2 were significantly higher in patients suffered from an event than those event -free subjects [（288.732±124.873） ng/ mL vs (231.537±92.059) ng/ mL]，P<0.05;(4)Lp-PLA2 was found to be an independent risk factor in AMI patients for the in-hospital MACE in the regression analysis . Conclusions:Lp-PLA2 is positively correlated with the in-hospital adverse cardiovascular events in patients with AMI，and it’s an important biomarker in the risk stratification for in-hospital AMI patients.

参考文献/References:

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备注/Memo

备注/Memo:

作者简介 宋温婷（1989-），女，硕士在读，研究方向：动脉硬化性心血管疾病的诊断和治疗；

通信作者：刘相丽，E-mail：liuxl98@163.com。

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更新日期/Last Update: 2016-03-23