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《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:

21卷

期数:

2015年01期

页码:

48-50

栏目:

临床医学

出版日期:

2015-01-20

文章信息/Info

Title:

Effects of primary percutaneous coronary intervention in patients with acute ST-elevation myocardial infarction at QTc , Tp-Te and Tp-Tec interval

文章编号:

1006-8147（2015）0-0048-03

作者:

张 坤¹; 李广平²; 上官文锋²

(1.天津医科大学研究生院,天津300070;2.天津医科大学第二医院心脏科,天津300211)

Author(s):

 ZHANG Kun¹ ;  LI Guang-ping²;  SHANGGUAN Wen-feng²

(1.Graduate School, Tianjin Medical University, Tianjin 300070, China; 2.Department of Cardiology, The Second Hospital , Tianjin Medical University, Tianjin 300211, China)

关键词:

急性心肌梗死; 经皮冠状动脉介入治疗; T波峰末间期

Keywords:

acute myocardial infarction' target="_blank" rel="external"> TEXT-ALIGN: left" align="left">acute myocardial infarction;  percutaneous coronary intervention;  T-wave peak to end interval

分类号:

R542.2+2

DOI:

-

文献标志码:

A

摘要:

目的：观察急性ST段抬高型心肌梗死（STEMI）患者急诊经皮冠状动脉介入治疗（pPCI）前后心室肌跨壁复极离散度指标（QTc、Tp-Te、Tp-Tec间期）的差异。方法：回顾分析245例STEMI患者，其中行pPCI治疗（干预组）188例，未行急诊PCI（对照组）57例，采集其入院即刻及入院第3天标准12导联心电图进行分析。结果：（1）干预组患者入院第3天和入院即刻比较，QTc间期无明显变化（P =0.277），Tp-Te间期、Tp-Tec间期均明显减小（P <0.001）；对照组患者入院第3天和入院即刻比较，QTc间期较前增大，TpTe间期、TpTec间期均较前减小（P 分别为：0.018，0.003，0.001）；与对照组比较，干预组入院第3天Tp-Te、Tp-Tec间期减小更明显。（2）干预组与对照组相比，住院期间恶性心律失常事件发生率降低（P < 0.05）。结论：急诊PCI术可使Tp-Te间期、Tp-Tec间期明显减小，比药物治疗可更有效的改善心室肌跨壁复极离散度，使恶性心律失常发生率降低。

Abstract:

Objective : To observe the effects of primary percutaneous coronary intervention (pPCI) in patients with acute ST-elevation myocardial infarction on transmural dispersion of repolarization (TDR). Methods: A retrospective analysis on 245 cases with acute STEMI. All of the patients were divided into two groups: 188 cases undergoing pPCI treatment as the intervention [1]group, and 57 cases without pPCI treatment as the control group. Corrected QT interval (QTc) and T-wave peak to end interval before and after correcting heart rate (Tp-Te , Tp-Tec) were measured on admission and on the third day after admission. Results: （1）Intervention group: QTc interval on the third day had no statistical significance compared with that on admission (P=0.277), while the Tp-Te, Tp-Tec intervals were both significantly decreased (P<0.05). Control group: QTc interval was longer on the third day and Tp-Te, Tp-Tec intervals were both significantly decreased (P<0.05), as compared to the intervention group;（2）Comparing with the control group, the intervention group had a lower incidence of malignant arrhythmia (P<0.05). Conclusion: Primary PCI could make Tp-Te, Tp-Tec intervals decrease significantly, thus improving TDR and reducing the incidence of malignant arrhythmia as compared to absolute medicine therapy.

 

参考文献/References:

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备注/Memo

备注/Memo:

作者简介 张坤（1985-），男，硕士在读，研究方向：冠心病基础与临床；E-mail：napo00@163.com。

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更新日期/Last Update: 2015-06-10