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《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:

22卷

期数:

2016年01期

页码:

21-23

栏目:

临床医学

出版日期:

2016-01-20

文章信息/Info

Title:

Correlation between thyroid hormone and cognitive function in hospitalized patients with chronic heart failure

文章编号:

1006-8147（2016）01-0021-03

作者:

牛伟华; 李广平

(天津医科大学第二医院心脏科,天津300211)

Author(s):

NIU Wei-hua;  LI Guang-ping

(Department of Cardiology, The Second Hospital, Tianjin Medical University, Tianjin 300211, China)

关键词:

line-height: 150%; " align="left">心力衰竭; 甲状腺激素; 认知功能

Keywords:

heart failure;  thyroid hormone;  cognitive function

分类号:

R541.6

DOI:

-

文献标志码:

A

摘要:

目的：探讨慢性心力衰竭（ CHF）患者甲状腺激素（ TH）水平与认知功能的关系。方法：便利抽取181例CHF患者，记录年龄、性别、文化程度、心衰病因、心衰病程等一般资料，测定空腹TH水平，采用蒙特利尔认知评估量表（ MoCA）评估认知功能。根据 MoCA评分将CHF患者分为认知功能障碍组（MoCA评分<26分）与认知功能正常组（MoCA评分≥26分），比较两组间TH水平的差异，同时探讨CHF患者TH与认知功能之间的关系。结果：CHF患者的认知功能总分为（24.99±2.81）分。认知功能障碍组比认知功能正常组血清游离三碘甲状腺原氨酸（FT3）水平低，差异有统计学意义（P<0.05）。相关分析显示：CHF患者 FT3与认知功能总分、视空间与执行能力、注意力、定向得分呈正相关（P<0.05）；血清游离甲状腺素（FT4）与视空间与执行能力得分呈正相关（P<0.05）。结论：CHF患者FT3水平的降低与认知功能障碍之间存在一定的相关性。

Abstract:

Objective: To investigate the relationship between thyroid hormone and cognitive function in hospitalized patients with chronic heart failure (CHF). Methods: A convenience sample of 181 hospitalized patients with CHF was selected to assess cognitive function using the Montreal Cognitive Assessment (MoCA). The levels of free three iodine thyroid original acid (FT3), free thyroxine (FT4) and thyroid stimulating hormone (TSH) were measure by chemical radiation immune method. The baseline clinical data were detected, including age, sex, education level, the cause of heart failure, and the course of disease. According to the MoCA scores, CHF patients were divided into normal cognitive function group and abnormal cognitive function group, respectively. The levels of TH between two groups were compared, and the relationship between TH and cognitive function were evaluated. Results: The total score of cognitive function in patients with chronic heart failure was 24.99±2.81 points. The level of FT3 in patients with cognitive impairment was lower than those with normal cognitive function (P<0.05). The level of FT3 was positively associated with the score of cognitive function and cognitive domains of visuospatial/executive function, attention and orientation. The level of FT4 was positively correlated with the score of cognitive domain of visuospatial/executive function. Conclusion: The decline of FT3 is associated with cognitive impairment in patients with CHF.

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参考文献/References:

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备注/Memo

备注/Memo:

作者简介 牛伟华（1988-），男，硕士在读，研究方向：心血管内科；

通信作者：李广平，E-mail: tjcardiol@126.com。

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更新日期/Last Update: 2016-01-25