[1]佟若菲,张 囡,李维超,等.氯霉素凝胶剂的制备与质量标准研究[J].天津医科大学学报,2015,21(05):446-448.
TONG Ruo-fei,ZHANG-Nan,LI Wei-chao,et al.Preparation of chloramphenicol gel with quality control[J].Journal of Tianjin Medical University,2015,21(05):446-448.
点击复制
氯霉素凝胶剂的制备与质量标准研究(PDF)
TONG Ruo-fei,ZHANG-Nan,LI Wei-chao,et al.Preparation of chloramphenicol gel with quality control[J].Journal of Tianjin Medical University,2015,21(05):446-448.
《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]
- 卷:
- 21卷
- 期数:
- 2015年05期
- 页码:
- 446-448
- 栏目:
- 技术与方法
- 出版日期:
- 2015-09-20
文章信息/Info
- Title:
- Preparation of chloramphenicol gel with quality control
- 文章编号:
- 1006-8147(2015)05-0446-03
- Author(s):
- TONG Ruo-fei1; 2; ZHANG-Nan2; LI Wei-chao2; FANG Zhi-zhong2
- （1. Department of Pharmacy, Tianjin Children′s Hospital，Tianjin 300074, China;2. College of Pharmacy, Tianjin Medical University, Tianjin 300070, China）
- Keywords:
- chloramphenicol; gel; preparation; quality control.
- 分类号:
- R9
- DOI:
- -
- 文献标志码:
- A
- 摘要:
-
目的：制备氯霉素凝胶剂并建立其质量控制方法。方法：以氯霉素为主药，以卡波姆-940为凝胶基质，制备氯霉素凝胶剂；采用高效液相色谱法测定氯霉素的含量，测定波长为277 nm。结果：该品为无色透明，均匀细腻的凝胶，质量符.合2010年版《中国药典》中的相关规定；氯霉素浓度在39.84~249.00 ?g/mL范围内线性关系良好(r=0.999 9)，平均回收率为100.3%(RSD=0.81％)。结论：该处方工艺简单、实用，质量控制方法可靠、易行。
?
- Abstract:
- Objective：To investigate the preparation of chloramphenicol gel and establish the methods for its quality control．Methods：Chloramphenicol gel was prepared by using chloramphenicol as a main drug and carbopoler 940 as gel matrix. The concentration of chloramphenicol in the gel formulation was determined by HPLC at the detection wave length of 277 nm．Results：The prepared formulation was a colorless transparent gel and its quality met the relevant requirements in Chinese Pharmacopoeia in2010 edition．The concentration of chloramphenicol was determined by HPLC and its linear range was 39.84-249.00 ?g/mL (r=0.9999)． The average recovery rate was 100.3% (RSD=0.81%，n=9)．Conclusion：The preparation of chloramphenicol gel is simple and practical, and the quality control methods are reliable and simple．
参考文献/References:
[1]陈新谦. 新编药物学[M]. 第17版.北京:人民卫生出版社, 2011 [2]天津市食品药品监督管理局.天津市医疗机构制剂规范[S]. 2008:31 [3]国家药典委员会. 中华人民共和国药典-二部[M].北京:中国医药科技出版社, 2010 [4]翟学娜，刘青，王姿婧，等. 加替沙星眼用凝胶剂的制备与质量控制[J]. 天津医科大学学报, 2012,18(3):392 [5]李金伟，董根山，何西奎，等. 依沙吖啶凝胶的制备及质量控制[J]. 中国药物与临床, 2012,12(1):51 [6]施霞，范义凤，李德明，等. 复方酮康唑凝胶剂的研制方法研究[J]. 临床合理用药杂志, 2012,5(2):42 [7]张囡，王冬. HPLC法测定复方氯霉素乳膏中氯霉素含量[J]. 天津药学, 2010,22(2):14 [8]涂初芳，蒋藤川. HPLC法测定氯霉素搽剂中氯霉素的含量[J]. 中国药师, 2010,13(12):1832 [9]崔福德. 药剂学[M]. 第4版.北京:人民卫生出版社, 2003:172-173 [10]夏爱晓，张昊，朱丹燕，等. 双嘧达莫凝胶剂的制备与质量控制[J]. 中国药业, 2011,20(12):43 [11]Agarwal V, Singh S K, Reddy I K, et al. Cataplasm-based controlled drug delivery: development and optimization of a novel formulation[J]. Drug Dev Ind Pharm, 1999,25(5):659 [12]Rathnam G, Narayanan N, Ilavarasan R. Carbopol-based gels for nasal delivery of progesterone[J]. AAPS PharmSciTech, 2008,9(4):1078 [13]何用忠, 杨林. 尼美舒利凝胶剂的制备与质量控制[J]. 医药导报, 2011,30:159
相似文献/References:
备注/Memo
- 备注/Memo:
- 作者简介 佟若菲（1977-），女，副主任药师，学士，研究方向：临床药学；通信作者：房志仲，E-mail:fangzhizhong@tijmu.edu.cn。
常用功能
统计/Statistics
- 摘要浏览/Viewed1299
- 全文下载/Downloads1552
- 评论/Comments
