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[1]张 洁,张 飞 综 述,牛瑞芳 审 校.SHP2在肿瘤中的研究进展[J].天津医科大学学报,2015,21(03):269-271.
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《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:
21卷
期数:
2015年03期
页码:
269-271
栏目:
综述
出版日期:
2015-05-20

文章信息/Info

Title:
-
文章编号:
1006-8147（2015）03-0269-03
作者:
张 洁; 张 飞 综 述 ; 牛瑞芳 审 校

（天津医科大学肿瘤医院公共实验室，国家肿瘤临床医学研究中心，天津市“肿瘤防治”重点实验室，天津300060）

Author(s):
-
关键词:
 ; SHP2; 癌症转移; 促癌基因
Keywords:
-
分类号:
R730.231
DOI:
-
文献标志码:
A
摘要:
-
Abstract:
-

参考文献/References:

[1]Liu W, Yu B, Xu G, et al.Identification of cryptotanshinone as an inhibitor of oncogenic protein tyrosine phosphatase SHP2 (PTPN11)[J].J Med Chem,2013,56(18):7212

[2]Duan Y Q, Ma Y, Wang X J, et al.Design potential selective inhibitors for treating Cancer by targeting the Src homology 2 (SH2) Domain-Containing phosphatase 2 (Shp2) with core hopping approach[J].Protein Pept Lett,2014,21(6):556

[3]Yu B, Liu W, Yu W M, et al.Targeting protein tyrosine phosphatase SHP2 for the treatment of PTPN11-Associated malignancies[J].Mol Cancer Ther,2013,12(9):1738

[4]Zhou X D, Agazie Y M.Inhibition of SHP2 leads to mesenchymal to epithelial transition in breast Cancer cells[J].Cell Death Differ,2008,15(6):988

[5]Aceto N, Sausgruber N, Brinkhaus H, et al.Tyrosine phosphatase SHP2 promotes breast Cancer progression and maintains tumor-initiating cells via activation of key transcription factors and a positive feedback signaling loop[J].Nat Med,2012,18(4):529

[6]Zhang X, Lavoie G, Fort L, et al.Gab2 phosphorylation by RSK inhibits Shp2 recruitment and cell motility[J].Mol Cell Biol,2013,33(8):1657

[7]Mariotto S, Ciampa A R, de Prati A C, et al.Aqueous extract of Arbutus unedo inhibits STAT1 activation in human breast Cancer cell line MDA-MB-231 and human fibroblasts through SHP2 activation[J].Med Chem,2008,4(3):219

[8]Zhou X D, Agazie Y M.Molecular mechanism for SHP2 in promoting HER2-induced signaling and transformation[J].J Biol Chem,2009,284(18):12226

[9]Lee I O, Kim J H, Choi Y J, et al.Helicobacter pylori CagA phosphorylation status determines the gp130-activated SHP2/ERK and JAK/STAT signal transduction pathways in gastric epithelial cells[J].J Biol Chem,2010,285(21):16042

[10]Lazzara M J, Lane K, Chan R, et al.Impaired SHP2-mediated extracellular signal-regulated kinase activation contributes to gefitinib sensitivity of lung Cancer cells with epidermal growth factor receptor-activating mutations[J].Cancer Res,2010,70(9):3843

[11]Xie H, Huang S, Li W, et al.Upregulation of Src homology phosphotyrosyl phosphatase 2 (Shp2) expression in oral Cancer and knockdown of Shp2 expression inhibit tumor cell viability and invasion in vitro[J].Oral Surg Oral Med Oral Pathol Oral Radiol,2014,117(2):234

[12]Gu J, Han T, Ma R H, et al.SHP2 promotes laryngeal Cancer growth through the Ras/Raf/Mek/Erk pathway and serves as a prognostic indicator for laryngeal Cancer[J].Int J Oncol,2014,44(2):481

[13]Meng F, Zhao X, Zhang S.Expression and significance of SHP-2 in human papillomavirus infected cervical Cancer[J].J Huazhong Univ Sci Technolog Med Sci,2012,32(2):247

[14]Bard-Chapeau E A, Li S, Ding J, et al.Ptpn11/Shp2 acts as a tumor suppressor in hepatocellular carcinogenesis[J].Cancer Cell, 2011,19(5):629

[15]Yang W, Wang J, Moore D C, et al.Ptpn11 deletion in a novel progenitor causes metachondromatosis by inducing hedgehog signalling[J].Nature,2013,499(7459):491

[16]Zhou X, Coad J, Ducatman B, et al.SHP2 is up-regulated in breast Cancer cells and in infiltrating ductal carcinoma of the breast, implying its involvement in breast oncogenesis[J]. Histopathology, 2008,53(4):389

[17]Sausgruber N, Coissieux M M, Britschgi A, et al.Tyrosine phosphatase SHP2 increases cell motility in triple-negative breast Cancer through the activation of SRC-family kinases[J].Oncogene,2014, [Epub ahead of print]



[18]Hartman Z R, Schaller M D, Agazie Y M.The tyrosine phosphatase SHP2 regulates focal adhesion kinase to promote EGF-induced lamellipodia persistence and cell migration[J].Mol Cancer Res,2013,11(6):651

[19]Wang H C, Chiang W F, Huang H H, et al.Src-homology 2 domain-containing tyrosine phosphatase 2 promotes oral Cancer invasion and metastasis[J].BMC Cancer,2014,14:442

[20]Tang C, Luo D, Yang H, et al.Expression of SHP2 and related markers in non-small cell lung Cancer: a tissue microarray study of 80 cases[J].Appl Immunohistochem Mol Morphol,2013,21(5):386

[21]Tang C, Zhou X, Yang H, et al.Expression and its clinical significance of SHP2 in non-small cell lung Cancer[J].Zhongguo Fei Ai Za Zhi,2010,13(2):98

[22]Li S, Wang L, Zhao Q, et al.SHP2 positively regulates TGFbeta1-induced epithelial-mesenchymal transition modulated by its novel interacting protein hook1[J].J Biol Chem,2014, 289(49):34152

[23]Dong S, Li F Q, Zhang Q, et al.Expression and clinical significance of SHP2 in gastric Cancer[J].J Int Med Res,2012,40(6):2083

[24]Yang X Q, Dutta U, Shaw L M.SHP2 mediates the localized activation of Fyn downstream of the alpha 6 beta 4 integrin to promote carcinoma invasion[J].Mol Cell Biol,2010,30(22):5306

[25]Pan Y R, Cho K H, Lee H H, et al.Protein tyrosine phosphatase SHP2 suppresses podosome rosette formation in Src-transformed fibroblasts[J].J Cell Sci,2013,126(Pt 2):657

[26]Nabinger S C, Chan R J.Shp2 function in hematopoietic stem cell biology and leukemogenesis[J].Curr Opin Hematol,2012,19(4):273

[27]Zheng H, Li S H, Hsu P, et al.Induction of a tumor-associated activating mutation in protein tyrosine phosphatase Ptpn11 (Shp2) enhances mitochondrial metabolism, leading to oxidative stress and senescence[J].J Biol Chem,2013,288(36):25727

[28]Cheng H L, Su S J, Huang L W, et al.Arecoline induces HA22T/VGH hepatoma cells to undergo anoikis - involvement of STAT3 and RhoA activation[J].Mol Cancer,2010,9:126

[29]Morales L D, Casillas Pavón E A, Shin J W, et al.Protein tyrosine phosphatases PTP-1B, SHP-2, and PTEN facilitate Rb/E2F-associated apoptotic signaling[J].PLoS One,2014,9(5):e97104

[30]Li L, Modi H, Mcdonald T, et al.A critical role for SHP2 in STAT5 activation and growth factor-mediated proliferation, survival, and differentiation of human CD34(+) cells[J].Blood,2011,118(6):1504

[31]Furcht C M, Buonato J M, Skuli N, et al.Multivariate signaling regulation by SHP2 differentially controls proliferation and therapeutic response in glioma cells[J].J Cell Sci,2014,127(Pt 16):3555

[32]Hu Z, Fang H, Wang X, et al.Overexpression of SHP2 tyrosine phosphatase promotes the tumorigenesis of breast carcinoma[J].Oncol Rep,2014,32(1):205

[33]Yang Z, Li Y, Yin F, et al.Activating PTPN11 mutants promote hematopoietic progenitor cell-cycle progression and survival[J].Exp Hematol,2008,36(10):1285

[34]Tsang Y H, Han X, Man W Y, et al.Novel functions of the phosphatase SHP2 in the DNA replication and damage checkpoints[J].PLoS One,2012,7(11):e49943

[35]Buet D, Gallais I, Lauret E, et al.Cotargeting signaling pathways driving survival and cell cycle circumvents resistance to Kit inhibitors in leukemia[J].Blood,2012,119(18):4228

[36]Peng G, Cao R B, Li Y H, et al.Alterations of cell cycle control proteins SHP1/2, p16, CDK4 and cyclin D1 in radioresistant nasopharyngeal carcinoma cells[J].Mol Med Rep,2014,10(4):1709

[37]Xu J, Zeng L F, Shen W, et al.Targeting SHP2 for EGFR inhibitor resistant non-small cell lung carcinoma[J].Biochem Biophys Res Commun,2013,439(4):586

[38]Wang Y C, Chen C L, Sheu B S, et al.Helicobacter pylori infection activates Src homology-2 domain-containing phosphatase 2 to suppress IFN-gamma signaling[J].J Immunol,2014,193(8):4149

[39]Zhang L, Yang Z, Ma A, et al.Growth arrest and DNA damage 45G down-regulation contributes to Janus kinase/signal transducer and activator of transcription 3 activation and cellular senescence evasion in hepatocellular carcinoma[J].Hepatology,2014,59(1):178

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备注/Memo

备注/Memo:
基金项目 国家自然科学基金（81372844）；天津医科大学科研基金（2009ky21）;教育部博士点基金(20131202110002)

作者简介 张洁（1989-），女，硕士在读，研究方向：生物化学与分子生物学；通信作者：牛瑞芳，E-mail：niuruifang@tjmuch.com。

更新日期/Last Update: 2015-05-27