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《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:

21卷

期数:

2015年03期

页码:

217-219

栏目:

基础医学

出版日期:

2015-05-20

文章信息/Info

Title:

Studies on chemical constitunents in the South China Sea marine sponge Axinella sp.

文章编号:

1006-8147（2015）03-0217-03

作者:

 许娇娇 ¹;  2; 顾 琼¹;  2; 王 佳¹;  2; 赵 川³; 段宏泉¹;  2; 3; 乔 卫¹;  2; 唐生安^{1;  2}

 (1.天津医科大学药学院,天津300070; 2.天津市临床药物关键技术重点实验室，天津300070; 3.天津医科大学基础医学研究中心,天津300070）

Author(s):

XU Jiao-jiao¹;  2;  GU Qiong¹;  2;  WANG Jia¹;  2;  ZHAO Chuan³;  DUAN Hong-quan ¹;  2;  3;  QIAO Wei¹;  2;  TANG Sheng-an¹;  2; 

(1.School of Pharmacy, Tianjin Medical University, Tianjin 300070, China; 2.Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics (Theranostics), Tianjin 300070, China; 3.Research Center of Basic Medical Sciences, Tianjin Medical University, Tianjin 300070, China)

关键词:

 ; 南海海绵; Axinella sp.; 结构鉴定; 溴代吡咯烷型生物碱

Keywords:

 ; marine sponge;  Axinella sp.;  structure identification;  bromopyrrole alkaloids

分类号:

R282.77

DOI:

-

文献标志码:

A

摘要:

目的：研究中国南海海绵Axinella sp.的化学成分。方法：用硅胶柱色谱、制备薄层色谱、凝胶柱色谱和半制备HPLC等分离纯化,并采用质谱、核磁共振波谱等有机波谱方法鉴定化合物的结构。结果:从海绵Axinella sp.中分离的7个化合物,依次鉴定为debromohymenialdisine (1), hymenialdisine (2), aldisin (3), 3-bromoaldisin (4), 尼克酰胺 (5), 胸腺嘧啶 (6), 尿嘧啶 (7)。结论:化合物1～4是海绵中特有的溴代吡咯烷型生物碱，化合物5, 6, 7为首次从该属海绵中分离得到。

Abstract:

Objective: To investigate the chemical constituents in the South China Sea marine sponge Axinella sp. Methods: Various chromatography techniques (silica gel, preparative TLC, Sephadex LH-20 and semi-preparative HPLC) were performed to isolate and purify the extracts. The structures were identified mainly by extensive spectral data analysis. Results: Seven compounds were isolated and their structures were identified as debromohymenialdisine (1), hymenialdisine (2), aldisin (3), 3-bromoaldisin (4), niacinamide (5), thymine (6), uracil (7). Conclusion: Compounds 1-4 are specific bromopyrrole alkaloids of marine sponges, and compounds 5, 6, 7 are isolated for the first time from the genus Axinella.

参考文献/References:

[1] HassanW, ElkhayatE S, EdradaR A, et al. New bromopyrrole alkaloids from the marine sponges axinella damicornis and stylissa flabelliformis[J]. Nat Prod Commun, 2007, 2 (11):1149

[2] Dai J, Fishback J A, Zhou Y, et al. Sodwanone and yardenone triterpenes from a South African Species of the marine sponge Axinella inhibit hypoxia-Inducible factor-1 (HIF-1) activation in both breast and prostate tumor cells[J]. J Nat Prod, 2006, 69 (12): 1715

[3] Gallimore W A , Cabrala C, Kellyb M, et al. A novel D-ring unsaturated A-nor sterol from the Indonesian sponge, Axinella carteri Dendy[J]. Nat Prod Res, 2008, 22(15): 1339

[4] Zhang H, Khalil Z, Conte M M, et al. A search for kinase inhibitors and antibacterial agents:bromopyrrolo-2-aminoimidazoles from a deep-water Great Australian Bight sponge, Axinella sp[J]. Tetrahedron Lett, 2012, 53(29):3784

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[7] Sauleau P, Retailleau P, Nogues S, et al. Dihydrohymenialdisines, newpyrrole-2-aminoimidazole alkaloids from the marine sponge Cymbastela cantharella[J]. Tetrahedron Lett, 2011, 52(21): 2676

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备注/Memo

备注/Memo:

基金项目 国家自然科学基金资助项目(81102371), 天津市自然科学基金资助项目(10JCYBJC15000)

作者简介 许娇娇(1989-)女，硕士在读，研究方向：天然产物有效分离、分析研究；通信作者：唐生安，E-mail: tangshengan@tijmu.edu.cn。

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更新日期/Last Update: 2015-05-27