|本期目录/Table of Contents|

[1]顾 琼,焦 扬,赵 川,等.中国南海海绵Jaspis stellifera中异臭椿型萜类成分研究[J].天津医科大学学报,2014,20(05):357-359.
　GU Qiong,JIAO Yang,ZHAO Chuan,et al.Studies on chemical constituents of Jaspis stellifera [J].Journal of Tianjin Medical University,2014,20(05):357-359.
点击复制

中国南海海绵Jaspis stellifera中异臭椿型萜类成分研究(PDF)
分享到：

《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:
20卷
期数:
2014年05期
页码:
357-359
栏目:
基础医学
出版日期:
2014-09-20

文章信息/Info

Title:

Studies on chemical constituents of Jaspis stellifera

文章编号:
1006-8147(2014)05-0357-03
作者:
顾 琼1; 焦 扬2; 赵 川3; 唐 铖1; 唐生安1; 段宏泉1;  3; 周 晶1
(1.天津医科大学药学院,天津市临床药物关键技术重点实验室,天津 300070;2.天津中医药大学第一附属医院药学部,天津 300193;3.天津医科大学基础医学研究中心,天津 300070)
Author(s):

GU Qiong1;  JIAO Yang2;  ZHAO Chuan3;  TANG Cheng1;  TANG Sheng-an1;  DUAN Hong-quan1; 3;  ZHOU Jing1

 (1.School of Pharmacy, Tianjin Medical University, Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics (Theranostics), Tianjin 300070, China; 2.Department of Pharmacy, The First Teaching Hospital of Tianjin University of TCM, Tianjin 300193, China；3. Research Center of Basic Medical Sciences, Tianjin Medical University, Tianjin 300070, China)
关键词:

南海海绵; Jaspis stellifera; 结构鉴定; 异臭椿型萜类

Keywords:
marine sponge;  Jaspis stellifera;  structure identification;  isomalabaricane-type terpenoids
分类号:
R9
DOI:
-
文献标志码:
A
摘要:

目的: 对采自中国南海海域海绵Jaspis stellifera中异臭椿型萜类成分进行分离鉴定。方法: 采用硅胶柱色谱、凝胶柱色谱和HPLC制备色谱和重结晶方法分离纯化得到单体化合物，采用有机波谱方法鉴定化合物结构。结果: 从Jaspis stellifera氯仿层萃取物中分离得到5个化合物，分别鉴定为22,23-dihydrostellettin B (1)、isogeoditin A (2)、stellettin A (3)、stellettin B (4)、jaspolide B (5)。结论：化合物1和2为首次从该属海绵中分离得到的异臭椿型萜类成分。

Abstract:
 Objective: To study the isomalabaricane-type terpenoids from the South China Sea marine sponge Jaspis stellifera. Methods: Chemical constituents were isolated and purified by repeated column chromatography (silica gel, Toyopearl HW-40C and preparative HPLC). Their structures were elucidated on the basis of spectral data analysis. Results: Five compounds (1-5) were obtained and their structures were identified by comparing their spectral data with literature values as follows: 22,23-dihydrostellettin B (1), isogeoditin A (2), stellettin A (3), stellettin B (4), jaspolide B (5). Conclusion: Compound 1 and 2 can be isolated for the first time from the genus Jaspis.

参考文献/References:

[1] 郭跃伟.欧洲海洋药物的研究现状及对我国海洋药物研究的启示[J].中国新药杂志, 2001, 10(2):81

[2] Naonobu T,Rei M, Azusa S,et a1．Stelliferins J-N, isomalabaricane-type triterpenoids from Okinawan marine sponge Rhabdastrella cf. globostellata [J]. Tetrahedron,2011,67 (4):6689

[3] Li J, Zhu H J, Ren J W,et a1.Globostelletins J-S,isomalabaricanes with unusual cyclopentane sidechains from the marine sponge Rhabdastrella globostellata [J].Tetrahedron,2012,68 (10):559

[4] Juntchi K,Osamu M.Jaspisamides A-C,new cytotoxic macrolides from the Okinawan sponge Jaspis sp.[J]. J Nat Prod,1993,56(5):787

[5] Amiram G,Joshua J N. Cytotoxic metabohtes from an Australian colection of the sponge Jaspis Species[J]. J Nat Prod,1999,62 (12):1691

[6] Zabriskie T M, Klocke K A, heland C M, et al. Jaspamide,a modified peptide from a Jaspis sponge,with insecticidal and antifungal activity[J]. J Am Chem Soc,1986,108(11):3123

[7] Lv F,Deng Z W,Li J, et a1. Isomalabaricane-Type Compounds from the Marine Sponge Rhabdastrella affdistincta [J]. J Nat Prod,2004,67(3):2033

[8] Su J Y, Meng Y H, Zeng L M. Cytotoxic stellettin A, a new triterpenoid pigment from the marine sponge Stelletta tenuis [J]. J Nat Prod,1994,7(10):1450

[9] McCabe T,Clardy J A.Triterpenoid pigment with the isoma labaricane skeleton from the sponge Stelletta sp . [J]. Tetrahedron Lett,1982,23(33) : 3307

[10] Tang S A,Pei Y H,Fu H Z,et al. Jaspolide A-F, six new isomalabricane-type terpenoids from the sponge Jaspis sp.[J]. Chem Pharm Bull,2006,54(1): 4

相似文献/References:

备注/Memo

备注/Memo:

 基金项目 国家自然科学基金资助(81102371) ,天津市自然科学基金资助(10JCYBJC15000)

作者简介 顾琼(1987-), 女, 研士在读, 研究方向：天然产物有效成分分离、分析研究；通信作者：唐生安, E-mail: tangshengan@tijmu.edu.cn。

更新日期/Last Update: 2014-09-25