|本期目录/Table of Contents|

[1]薛凡凡,常诗卉,菅喜岐.血管对高强度聚焦超声焦域影响的体模实验研究[J].天津医科大学学报,2014,20(04):275-278.
　XUE Fan-fan,CHANG Shi-hui,JIAN Xi-qi.Experimental study on the effect of blood vessel on high intensity focused ultrasound focal region in phantom[J].Journal of Tianjin Medical University,2014,20(04):275-278.
点击复制

血管对高强度聚焦超声焦域影响的体模实验研究(PDF)
分享到：

《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:
20卷
期数:
2014年04期
页码:
275-278
栏目:
基础医学
出版日期:
2014-07-08

文章信息/Info

Title:
Experimental study on the effect of blood vessel on high intensity focused ultrasound focal region in phantom
文章编号:
1006-8147（2014）04-0275-04
作者:
薛凡凡; 常诗卉; 菅喜岐
（天津医科大学生物医学工程学院，天津 300070）
Author(s):
XUE Fan-fan; CHANG Shi-hui; JIAN Xi-qi
(School of Biomedical Engineering, Tianjin Medical University, Tianjin 300070，China)
关键词:
高强度聚焦超声; 血管; 仿组织体模
Keywords:
high intensity focused ultrasound;  blood vessel;  tissue-mimicking phantom
分类号:
R730.5
DOI:
-
文献标志码:
A
摘要:
目的：通过含蛋清的仿组织体模模拟血管，实验研究血流、血管位置及管径对高强度聚焦超声（HIFU）形成焦域的影响。方法：以模拟血液流动的仿组织体模血管模型为对象，在水槽进行HIFU辐照实验，分析一定超声治疗剂量条件下不同血流、血管位置和管径对血管周边形成变色焦域体积的影响及其变化规律。结果：血流对HIFU焦域有一定的冷却效应；焦点与血管距离越近，焦域受血管影响越明显；直径2 mm血管在声轴上且位于焦点之后时与焦点的距离大于3 mm，血管位于焦点之前且距离大于8 mm，血管对HIFU焦域的影响可以忽略不计；直径2 mm血管中心垂直偏离声轴大于3 mm时，血管对焦域的影响同样也可以不予考虑；管径越大在其周边形成的焦域体积越小。结论：血管与焦点的相对距离越远，血管对HIFU焦域的影响越小，当血管远离焦点一定距离时其影响可以忽略不计。
Abstract:
Objective: To conduct an experiment with egg-white tissue-mimicking phantom containing simulated blood vessel to study the effect of blood vessels at different blood flow rates, locations and vessel diameters on high intensity focused ultrasound (HIFU) focal region. Methods: A phantom containing simulated blood vessel and blood flow was made with egg white，polyacrylamide etc. Experiments were performed in a degassed water tank under certain parameter condition. The volumes of the color-changing focal region formed by HIFU exposure were measured and the obtained data were statistically analyzed to discuss the effect of blood vessels at different blood flows, locations and diameters on HIFU focal region. Results: The cooling effect of vessel on focal region was observed during exposure. With decreased distance between vessel and focal point, the effect on focal region induced by blood vessel became more marked. The 2 mm blood vessel almost had no impact on the size of HIFU focal region when the blood vessel located on the acoustic axis at a distance larger than 8 mm to the focal point (before the focal point), or a distance smaller than 3 mm (behind the focal point). The effect of the blood vessel of 2 mm diameter was not significant when the vertical distance between the vessel center and the acoustic axis was larger than 3 mm. With increased vessel diameter, the volume of focal region near vessel became smaller. Conclusion: The longer the distance between the vessel and the focal point, the less effective of HIFU and can be neglected when a relative far distance is reached.

参考文献/References:

[1] Mason T J. Therapeutic ultrasound an overview[J]. Ultrason Sonochem, 2011,18(4):847

[2]Zhang L, Zhu H, Jin C B, et al . High-intensity focused ultrasound(HIFU):effective and safe therapy for hepatocellular carcinoma adjacent to major hepatic veins[J]. Eur Radiol, 2009,19(2):437

[3]Labuda C P, Church C C. Augmentation of HIFU-induced heating with fibers embedded in a phantom[J]. Ultrasound Med Biol, 2011,37(3):442

[4]Takegami K, Kaneko Y, Watanabe T, et al . Polyacrylamide gel containing egg white as new model for irradiation experiments using focused ultrasound[J]. Ultrasound Med Biol, 2004,30(10):1419

[5]Greaby R, Zderic V, Vaezy S. Pulsatile flow phantom for ultrasound image-guided HIFU treatment of vascular injuries[J]. Ultrasound Med Biol, 2007,33(8):1269

[6]董磊，张传森，管一帆，等. 肝细胞癌供血动脉的血流速度与微血管密度的关系[J]. 中华肿瘤杂志, 2005,27(9):538

[7]Jiang F, He M, Liu Y J, et al . High intensity focused ultrasound ablation of goat liver in vivo: Pathologic changes of portal vein and the "heat-sink" effect[J]. Ultrasonics, 2013,53(1):77

[8]张平，张晓静，朱元光，等. 血管位置对HIFU焦域温度场的影响[J]. 国际生物医学工程杂志, 2011,34(1):16

 

相似文献/References:

[1]曾苗苗,钱宇晗,常诗卉,等.骨骼对于高强度聚焦超声聚焦影响的实验研究[J].天津医科大学学报,2016,22(04):291.
　ZENG Miao-miao,QIAN Yu-han,CHANG Shi-hui,et al.Research on the influence of bone on high intensity focused ultrasound focusing[J].Journal of Tianjin Medical University,2016,22(04):291.
[2]郭嘉露,李心乐,李新,等.机械加载对高血压大鼠心血管及肾脏损伤的疗效观察[J].天津医科大学学报,2018,24(02):106.
　GUO Jia-lu,LI Xin-le,LI Xin,et al.Effect of mechanical loading on the angiocarpy and kidney damage in hypertensive rats[J].Journal of Tianjin Medical University,2018,24(04):106.
[3]钱宇晗,张艳秋,霍 然,等.HIFU经颅脑肿瘤治疗参数筛选的数值仿真研究001[J].天津医科大学学报,2018,24(05):369.
　QIAN Yu-han,ZHANG Yan-qiu,HUO Ran,et al.Study on parameters screening for the numerical simulation of transcranial tumor treatment with high intensity focused ultrasound[J].Journal of Tianjin Medical University,2018,24(04):369.

备注/Memo

备注/Memo:
基金项目 国家自然科学基金资助项目(81272495）
作者简介 薛凡凡（1986-），男，硕士在读，研究方向：超声医学；通信作者：菅喜岐，E-mail:jianxiqi@tijmu.edu.cn。
更新日期/Last Update: 2014-06-06