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《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:

20卷

期数:

2014年06期

页码:

486-489

栏目:

技术与方法

出版日期:

2014-11-20

文章信息/Info

Title:

Hydroxypropyl-β-cyclodextrin improving the solubility of asiatic acid

文章编号:

1006-8147（2014）06-0486-04

作者:

张  博¹; 2  ;  赵永亮³

(1.天津医科大学研究生院,天津 300070;2.天津市南开医院药剂科,天津 300100；3.国家纳米技术与工程研究院纳米粒子药物实验室,天津 300457)

Author(s):

 ZHANG Bo¹; 2 ; ZHAO Yong-liang³

(1.Graduate School ,Tianjin Medical University, Tianjin 300070,China; 2. Department of Pharmacy ,Tianjin Nankai Hospital, Tianjin 300100, China; 3.China National Academy of Nanotechnology Engineering, Tianjin 300457,China )

关键词:

积雪草酸; 羟丙基-β-环糊精; 溶解度; 络合物

Keywords:

asiatic acid;  hydroxypropyl--β-cyclodextrin ;  solubility;  complex

分类号:

R9

DOI:

-

文献标志码:

A

摘要:

目的:通过积雪草酸与羟丙基-β-环糊精（HP-β-CD）的络合作用来提高积雪草酸在水中的溶解度。方法: 用红外光谱（FTIR）、X-射线衍射（XRD）、差示扫描热仪（DSC）和扫描电镜（SEM）对积雪草酸/ HP-β-CD络合物的性质进行测试。结果:研究发现当积雪草酸: HP-β-CD为1：2时，积雪草酸在水中的溶解度达到2 100 μg/mL，是积雪草酸在水中溶解度的17倍。 红外光谱图和X-射线衍射图谱证实了积雪草酸/ HP-β-CD络合物以固体状态存在。扫描电镜、差示扫描热和X-射线衍射图谱表明积雪草酸以无定形形态存在于络合物中。结论：羟丙基-β-环糊精通过与积雪草酸络合，能有效增加积雪草酸的溶解度。

Abstract:

Objective: To improve the solubility of asiatic acid, a poorly water soluble drug, by combining with hydroxypropyl-β-cyclodextrin　(HP-β-CD). Methods: The asiatic acid/HP-β-CD solid complex system was characterized by Fourier Transform Infrared Spectroscopy (FTIR), X-ray diffraction (XRD), Differential Scanning Calorimetry (DSC)and Scanning Electron Microscopy(SEM). Results: The effect of asiatic acid: HP-β-CD feed ratio by molar on the aqueous solubility was investigated and the aqueous solubility of asiatic acid reached 2 100 μg/mL when the molar ratio of asiatic acid to HP-β-CD was 1:2. The aqueous solubility of asiatic acid was increased by 21-fold in asiatic acid/HP-β-CD solid complex. The FTIR and XRD spectra of asiatic acid/HP-β-CD solid complexes showed that Asiatic acid could form inclusion complex with HP-β-CD in solid status. The SEM, DSC and XRD spectra of asiatic acid/HP-β-CD solid complexes indicated asiatic acid was in amorphous status. Conclusion: Hydroxypropyl - β - cyclodextrin  can effectively increase the solubility of asiatic acid by combining with asiatic acid.

参考文献/References:

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相似文献/References:

备注/Memo

备注/Memo:

作者简介 张博（1984-）,女，药师，硕士在读，研究方向：中药学；E-mail:pinklavender1984@aliyun.com。

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更新日期/Last Update: 2014-12-03