[1] Maciejczyk A, Szelachowska J, Ekiert M, et al. Elevated nuclear YB1 expression is associated with poor survival of patients with early breast Cancer[J]. Anticancer Res, 2012,32(8):3177 [2]Chatterjee M, Rancso C, Stühmer T, et al.The Y-box binding protein YB-1 is associated with progressive disease and mediates survival and drug resistance in multiple myeloma[J]. Blood,2008,111(7):3714 [3]Lasham A, Moloney S, Hale T, et al.The Y-box-binding protein, YB1, is a potential negative regulator of the p53 tumor suppressor[J]. J Biol Chem,2003,278(37):35516 [4]Lasham A, Samuel W, Cao H, et al.YB-1, the E2F pathway, and regulation of tumor cell growth[J]. J Natl Cancer Inst,2012,104(2):133 [5]Rhodes D R, Kalyana-Sundaram S, Mahavisno V, et al. Mining for regulatory programs in the cancer transcriptome[J]. Nat Genet,2005,37(6):579 [6]Finkbeiner M R,Astanehe A,To K, et al.Profiling YB-1 target genes uncovers a new mechanism for Met receptor regulation in normal and malignant human mammary cells[J].Oncogene,2009,28(11):1421. [7]Jürchott K, Kuban R J, Krech T, et al. Identification of Y-box binding protein 1 as a core regulator of MEK/ERK pathway-dependent gene signatures in colorectal Cancer cells[J].PLoS Genet,2010,6(12):e1001231 [8]Basaki Y,Hosoi F,Oda Y, et al.Akt-dependent nuclear localization of Y-box-binding protein 1 in acquisition of malignant characteristics by human ovarian Cancer cells[J].Oncogene,2007,26(19):2736. [9]Cornu M,Albert V, Hall M N.mTOR in aging,metabolism,and Cancer[J].Curr Opin Genet Dev,2013,23(1):53 [10]Astanehe A,Finkbeiner M R,Hojabrpour P, et al.The transcriptional induction of PIK3CA in tumor cells is dependent on the oncoprotein Y-box binding protein-1[J].Oncogene,2009,28(25):2406 [11]Sutherland B W,Kucab J,Wu J, et al.Akt phosphorylates the Y-box binding protein 1 at Ser102 located in the cold shock domain and affects the anchorage-independent growth of breast Cancer cells[J].Oncogene,2005,24(26):4281 [12]Sinnberg T,Sauer B,Holm P, et al.MAPK and PI3K/AKT mediated YB-1 activation promotes melanoma cell proliferation which is counteracted by an autoregulatory loop[J].Exp Dermatol,2012,21(4):265 [13]Schittek B,Psenner K,Sauer B, et al.The increased expression of Y box-binding protein 1 in melanoma stimulates proliferation and tumor invasion, antagonizes apoptosis and enhances chemoresistance[J].Int J Cancer,2007,120(10):2110 [14]Fujii T,Seki N,Namoto-Matsubayashi R, et al.YB-1 prevents apoptosis via the mTOR/STAT3 pathway in HER-2-overexpressing breast Cancer cells[J].Future Oncol,2009,5(2):153 [15]De Luca A,Maiello M R,D’alessio A, et al.The RAS/RAF/MEK/ERK and the PI3K/AKT signalling pathways: role in Cancer pathogenesis and implications for therapeutic approaches[J].Expert Opin Ther Targets,2012,16(Suppl 2):S17 [16]Aksamitiene E,Kiyatkin A,Kholodenko B N.Cross-talk between mitogenic Ras/MAPK and survival PI3K/Akt pathways: a fine balance[J].Biochem Soc Trans,2012,40(1):139 [17]Wu J,Lee C,Yokom D, et al.Disruption of the Y-box binding protein-1 results in suppression of the epidermal growth factor receptor and HER-2[J].Cancer Res,2006,66(9):4872 [18]Moncho-Amor V,Ibañez de Cáceres I,Bandres E, et al.DUSP1/MKP1 promotes angiogenesis, invasion and metastasis in non-small-cell lung Cancer[J].Oncogene,2011,30(6):668 [19]Coles L S,Lambrusco L,Burrows J, et al.Phosphorylation of cold shock domain/Y-box proteins by ERK2 and GSK3beta and repression of the human VEGF promoter[J].FEBS Lett,2005,579(24):5372 [20]van Roeyen C R,Eitner F,Martinkus S, et al.Y-box protein 1 mediates PDGF-B effects in mesangioproliferative glomerular disease[J].J Am Soc Nephrol,2005,16(10):2985
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基金项目 国家自然科学基金青年基金资助项目(81202380),天津市应用基础与前沿技术研究计划青年基金项目(12JCQNJC07800),教育部博士点基金资助项目(20111202120016),天津医科大学科研基金(2013KYQ04)
作者简介 王勇(1981-),男,讲师,博士,研究方向:泌尿系统肿瘤; 通信作者:岳丹,E-mail:danyue0705@sina.cn。