|本期目录/Table of Contents|

[1]孙龙昊,陈俊航,杨甜甜,等.肿瘤浸润免疫细胞中自噬对肿瘤进展的影响[J].天津医科大学学报,2022,28(06):683-686.
点击复制

肿瘤浸润免疫细胞中自噬对肿瘤进展的影响(PDF)
分享到:

《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:
28卷
期数:
2022年06期
页码:
683-686
栏目:
综述
出版日期:
2022-11-20

文章信息/Info

Title:
-
文章编号:
1006-8147(2022)06-0683-04
作者:
孙龙昊陈俊航杨甜甜张杨 综述梁晓宇 审校
天津医科大学总医院普通外科,天津 300052
Author(s):
-
关键词:
自噬肿瘤免疫微环境肿瘤浸润免疫细胞
Keywords:
-
分类号:
R392.12
DOI:
-
文献标志码:
A
摘要:
细胞自噬是生物进化过程中高度保守的自我降解过程,可维持细胞内环境稳态和细胞生存,应对氧化应激、饥饿或缺氧等特殊条件。自噬在肿瘤发生及进展过程中所起的作用极其复杂,且常常处于相互矛盾的状态。既往有关肿瘤自噬的研究大多仅注重于肿瘤细胞本身;而最近有研究开始逐步阐明自噬在高度多样化的肿瘤免疫微环境中的意义。这些研究表明,自噬和免疫协同作用以影响肿瘤进展,为肿瘤免疫疗法提供了新的切入点。因此,了解肿瘤微环境中自噬与多种肿瘤浸润免疫细胞之间的关系至关重要,同时也为肿瘤自噬疗法提供理论依据。
Abstract:
-

参考文献/References:

[1] DEVIS-JAUREGUI L,ERITJA N,DAVIS M L,et al. Autophagy in the physiological endometrium and cancer[J]. Autophagy,2021,17(5):1077-1095.
[2] LI J,LIU J,XU Y,et al. Tumor heterogeneity in autophagy-dependent ferroptosis[J]. Autophagy,2021,17(11):3361-3374.
[3] CAMUZARD O,SANTUCCI-DARMANIN S,CARLE G F,et al. Autophagy in the crosstalk between tumor and microenvironment[J].Cancer Lett,2020,490:143-153.
[4] XIA H,GREEN D R,ZOU W. Autophagy in tumour immunity and therapy[J]. Nat Rev Cancer,2021,21(5):281-297.
[5] ANDERSON N R,MINUTOLO NG ,GILL S,et al. Macrophage-based approaches for cancer immunotherapy[J]. Cancer Res,2021, 81(5):1201-1208.
[6] CHEN D,ZHANG X,LI Z,et al. Metabolic regulatory crosstalk between tumor microenvironment and tumor-associated macrophages[J]. Theranostics,2021,11(3):1016-1030.
[7] DONG S,WANG Q,KAO Y R,et al. Chaperone-mediated autophagy sustains haematopoietic stem-cell function[J]. Nature,2021,591(7848):117-123.
[8] WEI Q,PINHO S,DONG S,et al. MAEA is an E3 ubiquitin ligase promoting autophagy and maintenance of haematopoietic stem cells[J]. Nat Commun,2021,12(1):2522.
[9] DAI E,HAN L,LIU J,et al. Autophagy-dependent ferroptosis drives tumor-associated macrophage polarization via release and uptake of oncogenic KRAS protein[J]. Autophagy,2020,16(11):2069-2083.
[10] SANJURJO L,ARAN G,T?魪LLEZ ?魪,et al. CD5L promotes M2 macrophage polarization through autophagy-mediated upregulation of ID3[J]. Front Immunol,2018,9:480.
[11] JIANG H,COURAU T,BORISON J,et al. Activating immune recognition in pancreatic ductal adenocarcinoma via autophagy inhibition,MEK blockade,and CD40 agonism[J]. Gastroenterology,2022, 162(2):590-603.
[12] ZHANG M,LIU F,ZHOU P,et al. The MTOR signaling pathway regulates macrophage differentiation from mouse myeloid progenitors by inhibiting autophagy[J]. Autophagy,2019,15(7):1150-1162.
[13] CHANG C P,SU Y C,LEE P H,et al. Targeting NFKB by autophagy to polarize hepatoma-associated macrophage differentiation[J]. Autophagy,2013,9(4):619-621.
[14] OH D S,LEE H K. Autophagy protein ATG5 regulates CD36 expression and anti-tumor MHC class Ⅱ antigen presentation in dendritic cells[J]. Autophagy,2019,15(12):2091-2106.
[15] XIONG H,CHEN Z,LIN B,et al. Naringenin regulates FKBP4/NR3C1/NRF2 axis in autophagy and proliferation of breast cancer and differentiation and maturation of dendritic cell[J]. Front Immunol,2022,12:745111.
[16] DE SOUZA ASC,GON?覶ALVES L B,LEPIQUE A P,et al. The role of autophagy in tumor immunology-complex mechanisms that may be explored therapeutically[J]. Front Oncol,2020,10:603661.
[17] PIETROCOLA F,BRAVO-SAN PEDRO J M,GALLUZZI L,et al. Autophagy in natural and therapy-driven anticancer immunosurveillance[J]. Autophagy,2017,13(12):2163-2170.
[18] LI Z L,ZHANG H L,HUANG Y,et al. Autophagy deficiency promotes triple-negative breast cancer resistance to T cell-mediated cytotoxicity by blocking tenascin-C degradation[J]. Nat Commun,2020,11(1):3806.
[19] YAMAMOTO K,VENIDA A,YANO J,et al. Autophagy promotes immune evasion of pancreatic cancer by degrading MHC-Ⅰ[J]. Nature,2020,581(7806):100-105.
[20] DOWLING S D,MACIAN F. Autophagy and T cell metabolism[J]. Cancer Lett,2018,419:20-26.
[21] CARLETON G,LUM J J. Autophagy metabolically suppresses CD8+ T cell antitumor immunity[J]. Autophagy,2019,15(9):1648-1649.
[22] WEI J,LONG L,YANG K,et al. Autophagy enforces functional integrity of regulatory T cells by coupling environmental cues and metabolic homeostasis[J]. Nat Immunol,2016,17(3):277-285.
[23] JACQUIN E,APETOH L. Cell-intrinsic roles for autophagy in modulating CD4 T cell functions[J]. Front Immunol,2018,9:1023.
[24] AMARAVADI R K,KIMMELMAN A C,DEBNATH J. Targeting autophagy in cancer: recent advances and future directions[J]. Cancer Discov,2019,9(9): 1167-1181.
[25] WHITE E,MEHNERT J M,CHAN C S. Autophagy,metabolism,and cancer[J]. Clin Cancer Res,2015,21(22):5037-5046.

相似文献/References:

[1]李 杨,齐建利,赵立平,等.xCT影响肝癌细胞转移的作用机制研究[J].天津医科大学学报,2014,20(02):93.
 LI Yang,QI Jian-li,ZHAO Li-ping,et al.Molecular mechanism of metastasis in hepatocellular carcinoma inhibited by xCT[J].Journal of Tianjin Medical University,2014,20(06):93.
[2]宋 虎,王 振,杜晨阳,等.肝缺血再灌注损伤过程中细胞自噬的研究进展[J].天津医科大学学报,2018,24(01):87.
[3]姚庆娟 综 述,孙龙昊,何向辉 审 校.自噬对肿瘤免疫微环境的调控作用及其相关治疗策略[J].天津医科大学学报,2019,25(02):180.
[4]蒋腾,朱仲玲综 述,阎昭审 校.二甲双胍抗肿瘤作用的研究进展[J].天津医科大学学报,2020,26(06):577.
[5]王夏雨,施继禹,贾傲,等.基于网络药理学探讨清胰汤治疗急性胰腺炎的作用机制[J].天津医科大学学报,2021,27(05):454.
 WANG Xia-yu,SHI Ji-yu,JIA Ao,et al.Mechanism of QingyiTang in the treatment of acute pancreatitis based on network pharmacology[J].Journal of Tianjin Medical University,2021,27(06):454.
[6]何磊,杜佳辉,李娜.miR-152通过靶向FGF2抑制肺癌A549细胞系的增殖侵袭[J].天津医科大学学报,2022,28(02):145.
 HE Lei,DU Jia-hui,LI Na.The effect of miR-152 on the proliferation and invasion of lung cancer A549 cell line regulated by FGF2[J].Journal of Tianjin Medical University,2022,28(06):145.
[7]张薇,辛灵,阎涛.AG490改善缺血性脑卒中后神经功能的机制研究[J].天津医科大学学报,2022,28(06):615.
 ZHANG Wei,XING Ling,YAN Tao.Mechanism of AG490 improving neurological function after ischemic stroke[J].Journal of Tianjin Medical University,2022,28(06):615.
[8]杨澜,周春雷,王艺霖,等.PKG抑制剂KT-5823对宫颈癌HeLa细胞活力、凋亡、自噬的影响[J].天津医科大学学报,2023,29(02):131.
 YANG Lan,ZHOU Chun-lei,WANG Yi-lin,et al.Effects of PKG inhibitor KT-5823 on viability,apoptosis and autophagy of cervical cancer HeLa cells[J].Journal of Tianjin Medical University,2023,29(06):131.
[9]陶文岐,姚朱华.达格列净或沙库巴曲缬沙坦对急性心肌梗死大鼠的作用机制探讨[J].天津医科大学学报,2023,29(04):406.
 TENG Jie,CHEN Ye-gangTAO Wen-qi.Exploring the mechanism of protective effect of dapagliflozin or sacubitril/valsartan in rats with acute myocardial infarction[J].Journal of Tianjin Medical University,2023,29(06):406.
[10]靳可青,刘银玥,王萌,等.虾青素通过自噬改善快速老化小鼠心脏组织损伤[J].天津医科大学学报,2024,30(01):35.[doi:10.20135/j.issn.1006-8147.2024.01.0035]
 JIN Keqing,LIU Yinyue,WANG Meng,et al.Astaxanthin improves cardiac tissue damage in rapidly aging mice through autophagy[J].Journal of Tianjin Medical University,2024,30(06):35.[doi:10.20135/j.issn.1006-8147.2024.01.0035]

备注/Memo

备注/Memo:
基金项目 国家自然科学基金(81702410);天津市自然科学基金(17JCQNJC11100);天津医科大学自然科学基金(2016KYZQ02)
作者简介 孙龙昊(1983-),男,副主任医师,博士,研究方向:肿瘤免疫微环境;
通信作者:梁晓宇,E-mail:323246418@qq.com。
更新日期/Last Update: 2022-11-20