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[1]陈立,贾兰宁,王义增,等.基于SEER数据库的甲状腺髓样癌预后分析[J].天津医科大学学报,2021,27(02):167-171.
 CHEN Li,JIA Lan-ning,WANG Yi-zeng,et al.Prognostic analysis of medullary thyroid carcinoma based on SEER data[J].Journal of Tianjin Medical University,2021,27(02):167-171.
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基于SEER数据库的甲状腺髓样癌预后分析(PDF)
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《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:
27
期数:
2021年02期
页码:
167-171
栏目:
临床医学
出版日期:
2021-03-15

文章信息/Info

Title:
Prognostic analysis of medullary thyroid carcinoma based on SEER data
文章编号:
1006-8147(2021)02-0167-05
作者:
陈立贾兰宁王义增王钰云段然何向辉
(天津医科大学总医院普通外科,天津普通外科研究所,天津 300070)
Author(s):
CHEN LiJIA Lan-ningWANG Yi-zengWANG Yu-yunDUAN RanHE Xiang-hui
(Department of General Surgery, General Hospital,Tianjin Medical University,Tianjin Institute of General Surgery,Tianjin,300070 China)
关键词:
甲状腺髓样癌SEER数据库预后分析Cox回归
Keywords:
medullary thyroid carcinomaSEER databaseprognosis analysisCox regression
分类号:
R736.1
DOI:
-
文献标志码:
A
摘要:
目的:探索影响甲状腺髓样癌的预后因素。方法:通过SEER*Stat软件收集SEER数据库中于2004—2015年行全甲状腺切除+淋巴结清扫,病理诊断明确提示为甲状腺髓样癌的867例患者,运用单因素与多因素Cox回归分析影响患者生存的独立因素,并分析独立危险因素的KM生存曲线。结果:纳入的867例患者平均随访时间60(29~94)个月,3年肿瘤特异性生存率96.1%,5年肿瘤特异性生存率95.1%,单因素Cox结果提示性别(HR=0.573,95%CI:0.337~0.973,P=0.039)、年龄(HR=3.12, 95%CI:2.06~4.71,P<0.001)、肿瘤直径(HR=3.02,95%CI:2.10~4.34,P<0.001)、M分期(HR=12.9,95% CI:7.38~22.4,P<0.001)、阳性淋巴结数量(HR=2.07,95% CI:1.62~2.65,P<0.001)以及淋巴结阳性率(HR=3.00,95%CI:2.17~4.14,P<0.001)与患者生存时间有关,多因素Cox回归分析表明,年龄(HR=3.43,95% CI:2.23~5.27,P<0.001)、肿瘤直径(HR=1.96,95%CI:1.36~2.83,P<0.001)、M分期(HR=7.03,95% CI:3.82~12.9,P<0.001)和淋巴结阳性率(HR=2.24,95% CI:1.59~3.15,P<0.00)是行甲状腺全切+淋巴结清扫的MTC患者的独立危险因素。结论:诊断年龄、肿瘤直径、远处转移和淋巴结阳性率是影响甲状腺全切+淋巴结清扫术后的甲状腺髓样癌患者肿瘤特异性生存率的独立危险因素。
Abstract:
Objective: To explore the prognostic factors affecting medullary thyroid carcinoma(MTC). Methods: SEER*Stat software was used to collect 867 patients with MTC from 2004 to 2015 who had total thyroidectomy and lymphadenectomy and whose pathological diagnosis was definite.Univariate and multivariate Cox regression was used to analyze the independent factors affecting the survival of patients, and to analyze the KM survival curve of independent risk factors. Results: The included 867 patients had an average follow-up time of 60(29-94) months,a 3-year tumor-specific survival rate of 96.1%,and a 5-year tumor-specific survival rate of 95.1%. Univariate Cox results suggested gender(HR=0.57,95% CI:0.337-0.973,P=0.039),age(HR=3.12,95% CI:2.06-4.71,P<0.001),tumor size(HR=3.02,95%CI:2.10-4.34,P<0.001), M stage(HR=12.9,95%CI:7.38-22.4,P<0.001) and lymph node ratio(LNR)(HR=3.00, 95%CI:2.17-4.14,P<0.001) are related to the survival time of patients. Multivariate Cox regression analysis shows that age(HR=3.43,95%CI:2.23-5.27,P<0.001),tumor size(HR=1.96,95%CI:1.36-2.83,P<0.001),M stage(HR=7.03,95%CI:3.82-12.9,P<0.001),number of positive lymph nodes(HR=2.07,95%CI:1.62-2.65,P<0.001) and lymph node ratio(HR=2.24,95%CI:1.59-3.15,P<0.001) were independent risk factors for patients with MTC undergoing total thyroidectomy and lymph node dissection. Conclusion: Age, tumor size, M stage and LNR are independent risk factors that affect the survival of patients with MTC undergoing total thyroidectomy and lymph node dissection.

参考文献/References:

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相似文献/References:

[1]宋宁宁,王义增,李欣,等.降钙素对甲状腺髓样癌诊断和术式选择的意义[J].天津医科大学学报,2017,23(03):239.
 SONG Ning-ning,WANG Yi-zeng,LI Xin,et al.Study on calcitonin in diagnosis and surgery selection in patients with medullary thyroid cancer[J].Journal of Tianjin Medical University,2017,23(02):239.

备注/Memo

备注/Memo:
基金项目 国家自然科学基金(81672641)
作者简介 陈立(1993-),男,硕士在读,研究方向:普通外科学;通信作者:何向辉,E-mail:hexh88@tmu.edu.cn。
更新日期/Last Update: 2021-03-10