|本期目录/Table of Contents|

[1]侯慧星,韩之波,池 颖,等.ESE-3在溃疡性结肠炎相关结肠癌中的意义[J].天津医科大学学报,2019,25(06):618-622.
 HOU Hui-xing,HAN Zhi-bo,CHI Ying,et al.The significance of ESE-3 in ulcerative colitis-associated colon cancer[J].Journal of Tianjin Medical University,2019,25(06):618-622.
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ESE-3在溃疡性结肠炎相关结肠癌中的意义(PDF)
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《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:
25
期数:
2019年06期
页码:
618-622
栏目:
临床医学
出版日期:
2019-11-20

文章信息/Info

Title:
The significance of ESE-3 in ulcerative colitis-associated colon cancer
文章编号:
1006-8147(2019)06-0618-05
作者:
侯慧星1韩之波2池 颖2曹晓沧1
(1.天津医科大学总医院消化科,天津 300052;2.中国医学科学院北京协和医学院血液学研究所,天津300020)
Author(s):
HOU Hui-xing1 HAN Zhi-bo2 CHI Ying2 CAO Xiao-cang1
(1. Department of Gastroenterology and Hepatology, General Hospital, Tianjin Medical University, Tianjin 300052, China;2.The State Key Laboratory of Experimental Hematology,Institute of Hematology and Hospital of Blood Diseases,Chinese Academy of Medical Science and Peking Union of Medical College, Tianjin 300020, China)
关键词:
上皮特异性Ets转录因子-3炎症性肠病UC相关结肠癌
Keywords:
ESE-3 inflammatory bowel diseaseulcerative colitis-associated colon cancer
分类号:
R574.6
DOI:
-
文献标志码:
A
摘要:
目的:探讨上皮特异性Ets转录因子-3(ESE-3)在溃疡性结肠炎(UC)及其癌变组织中的表达及意义。方法:采用免疫组化SP法、实时定量聚合酶链反应(Real-time PCR)检测UC及其癌变结肠组织标本中ESE-3的表达。结果:在结肠组织中,ESE-3表达于细胞核中,表达量在UC组织中与正常对照组织的表达无统计学差异(P>0.05);而在UC相关结肠癌组织中ESE-3的表达低于癌旁组织。结论:ESE-3可能参与了与UC相关结肠癌的发生。
Abstract:
Objective: To investigate the expression and significance of epithelium-specific Ets transcription factor-3(ESE-3) in ulcerative colitis(UC) and its cancerous tissues. Methods: Immunohistochemical and real-time quantitative polymerase chain reaction (Real-time PCR)were used to detect the expression of ESE-3 in UC and its cancerous colon tissue. Results: In the colon tissue, ESE-3 was expressed in the nucleus, and the expression level of ESE-3 in UC tissues was similar to control tissues(P>0.05); but in the cases of UC-associated colon cancer, the expression of ESE-3 was lower than para-carcinoma tissues. Conclusion: ESE-3 may be involved in the occurrence of UC-associated colon cancer.

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备注/Memo

备注/Memo:
作者简介 侯慧星(1991-),女,硕士在读;研究方向:炎症性肠病临床及基础治疗;通信作者:曹晓沧,E-mail:doccaoxc@163.com。
更新日期/Last Update: 2020-01-20