|本期目录/Table of Contents|

[1]冯冉冉,孙海柏,冯 爽,等.参附注射液对慢性阻塞性肺疾病的临床观察及其对免疫功能的影响[J].天津医科大学学报,2019,25(05):481-483+487.
　FENG Ran-ran,SUN Hai-bai,FENG Shuang,et al.Clinical observation of shenfu injection on chronic obstructive pulmonary disease and its effect on immune response[J].Journal of Tianjin Medical University,2019,25(05):481-483+487.
点击复制

参附注射液对慢性阻塞性肺疾病的临床观察及其对免疫功能的影响(PDF)
分享到：

《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:
25卷
期数:
2019年05期
页码:
481-483+487
栏目:
临床医学
出版日期:
2019-09-20

文章信息/Info

Title:
Clinical observation of shenfu injection on chronic obstructive pulmonary disease and its effect on immune response
文章编号:
1006-8147(2019)05-0481-03
作者:
冯冉冉1; 2; 孙海柏2; 冯 爽2; 白 虹1
（1.天津医科大学免疫学系，天津300070；2.天津市海河医院检验科，天津300350）
Author(s):
FENG Ran-ran1; 2;  SUN Hai-bai2;  FENG Shuang2;  BAI Hong1
（1.Department of Immunology, Tianjin Medical University, Tianjin 300070, China；2.Department of Clinical Laboratory, Tianjin Haihe Hospital, Tianjin 300350, China)
关键词:
参附注射液; 慢阻肺; 免疫功能; 临床疗效
Keywords:
shenfu injection; chronic obstructive pulmonary disease(COPD);  immune function; clinical curative effect
分类号:
R563
DOI:
-
文献标志码:
A
摘要:
目的：探讨参附注射液对慢性阻塞性肺疾病的临床治疗效果及其对免疫反应的影响。方法： 筛选我院收治的符合标准的160 例病人，根据随机数字表法，随机分为对照组和试验组，对照组给予基础西医治疗，试验组在对照组相同的治疗基础上加参附注射液，治疗周期为14 d。根据临床症状评价疗效，同时采用免疫比浊法检测治疗前后血清中免疫球蛋白IgA、IgM、IgG的含量。利用流式细胞术检测T淋巴细胞亚群CD4、CD8的水平。结果： 和对照组比较，试验组的总有效率显著增加，疗效显著。参附注射液试验组可以增加血清中免疫球蛋白IgA、IgM、IgG的水平，差异显著。和对照组比较，试验组增加T淋巴细胞亚群CD4，降低了CD8的水平。结论： 参附注射液可以显著增加慢性阻塞性肺疾病的治疗效果，增加免疫球蛋白的表达，增强免疫功能。
Abstract:
Objective: To investigate the clinical effect of shenfu injection on chronic obstructive pulmonary disease (COPD) and its effect on immune response. Methods: One hundred and sixty patients meeting the standard in our hospital were selected and randomly divided into control group and experimental group according to the random number table method. The control group was treated with basic western medicine. In the experimental group, shenfu injection was used in addition to basic treatment and the treatment period was 14 days. The efficacy was evaluated according to clinical symptoms. And the levels of immunoglobulin IgA, IgM and IgG in serum before and after treatment were detected by immunoturbidimetry. The levels of CD4 and CD8 of T lymphatic subsets were detected by flow cytometry. Results: Compared with the control group, the total effective rate and curative effect of the experimental group were significantly increased. In the experimental group of shenfu injection, IgA, IgM and IgG levels of immunoglobulin in serum were increased, with significant differences. The experimental group increased the T lymphatic subgroup CD4 and decreased the level of CD8. Conclusion: Shenfu injection may significantly increase the therapeutic effect of chronic obstructive pulmonary disease(COPD), increase the expression of immunoglobulin and enhance the immune function.

参考文献/References:

[1] Kochanek K D, Xu J, Murphy S L, et al. Deaths: preliminary data for 2009[J].Natl Vital Stat Rep, 2011,59(4):1
[2] Novosad S A, Barker A F. Chronic obstructive pulmonary disease and bronchiectasis[J].Curr Opin Pulm Med, 2013,19(2): 133
[3] 韩利红,张国俊.老年慢性阻塞性肺疾病患者血清细胞因子及细胞免疫的水平及意义[J].中国老年学杂志, 2014,34(21): 6065
[4] 徐浩, 陆晓东, 冯胜春. 铜绿假单胞菌致糖尿病并肺结核患者肺部感染的耐药特征分析[J]. 中国微生态学杂志, 2014, 26(12): 1431
[5] 罗娟,许晓琼,杨浩军.痰热清注射液联合头孢哌酮舒巴坦治疗小儿支气管肺炎的系统评价和Meta分析[J].实用预防医学,2012, 19(10):1547
[6] 何青青,沈美华,肖光华.参附注射液的应用概况[J].中国中医急症,2012,21(11):1808
[7] 中国人民解放军总后勤部卫生部. 临床疾病诊断依据治愈好转标准[M]. 人民军医出版社, 1987
[8] Angel Martinez-Garcia M, Jose Soler-Cataluna J, Donat Sanz Y, et al. Factors associated with bronchiectasis in patients with COPD[J].Chest, 2011, 140(5):1130
[9] 宋风,付义.慢性阻塞性肺疾病中医药临床研究进展[J].中医研究, 2018, 31(11): 65
[10] 吴明亮,朱婉萍,孔繁智.中医药调节慢性阻塞性肺疾病免疫功能的应用研究概况[J].浙江中医杂志, 2014, 49(1): 67
[11] 张圆,任长虹,吴晓丹,等.参附注射液的临床应用及药理机制研究进展[J].药物评价研究, 2018, 41(6): 211
[12] 朱晨晨.参附注射液临床应用的研究进展[J].海峡药学,2016, 28(8):115
[13] Zhuo S M, Li N, Zheng Y, et al. Expression of the lymphocyte chemokine XCL1 in lung tissue of COPD mice, and its relationship to CD4(+)/CD8(+) ratio and IL-2[J].Cell Biochem Biophys, 2015, 73(2):505
[14] Freeman C M, Han M K, Martinez F J, et al. Cytotoxic potential of lung CD8+T cells increases with chronic obstructive pulmonary disease severity and with in vitro stimulation by IL-18 or IL-15[J]. J Immunol, 2010,184(11): 6504
[15] 郑燚. 淋巴细胞趋化因子(XCL1)在COPD小鼠模型肺组织中的表达及其与CD4+、CD8+T淋巴细胞、IL-2的相关性分析[D].遵义医学院,2014

相似文献/References:

备注/Memo

备注/Memo:
基金项目 天津市卫生和计划生育委员会资助项目（2013kz042）
作者简介 冯冉冉（1986-），女，初级检验技师，硕士在读，研究方向：感染免疫；通信作者：白虹，E-mail: hongbai25@163.com。
更新日期/Last Update: 2019-10-11