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[1]魏小娟,郭 艳,高 琦.IL-1RN基因多态性与消化性溃疡发病相关性及机制分析[J].天津医科大学学报,2019,25(02):154-157.
 WEI Xiao-juan,GUO Yan,GAO Qi.Correlation analysis and mechanism of IL-1RN gene polymorphism and peptic ulcer[J].Journal of Tianjin Medical University,2019,25(02):154-157.
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《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:
25
期数:
2019年02期
页码:
154-157
栏目:
临床医学
出版日期:
2019-03-20

文章信息/Info

Title:
Correlation analysis and mechanism of IL-1RN gene polymorphism and peptic ulcer
文章编号:
1006-8147(2019)02-0154-04
作者:
魏小娟郭 艳高 琦
(新乡市中心医院消化内科,新乡453000)
Author(s):
WEI Xiao-juan GUO Yan GAO Qi
(Department of Gastroenterology, Xinxiang Central Hospital, Xinxiang 453000,China)
关键词:
白细胞介素-1受体拮抗剂基因多态性十二指肠溃疡胃溃疡
Keywords:
interleukin -1 receptor antagonist gene polymorphism duodenal ulcer gastric ulcer
分类号:
R573.1
DOI:
-
文献标志码:
A
摘要:
目的:探讨白细胞介素-1受体拮抗剂(IL-1RN)基因多态性与消化性溃疡的相关性。方法:选取2016年1月-2018年1月在我院治疗的消化性溃疡患者180例,其中十二指肠溃疡患者91例(十二指肠溃疡组),胃溃疡患者89例(胃溃疡组),同时选取健康志愿者270例作为对照组,检查IL-1RN基因多态性,采用快速尿素酶测定幽门螺旋杆菌感染情况。结果:十二指肠溃疡组IL-1RN基因型L/2+2/2比例和等位基因2比例分别为50.55%和29.67%,明显高于胃溃疡组和对照组(P<0.05);十二指肠溃疡组幽门螺旋杆菌阳性者IL-1RN基因型L/2+2/2比例和等位基因2比例分别为50.15%和29.38%,明显高于胃溃疡组和对照组(P<0.05);胃溃疡组幽门螺旋杆菌阴性者IL-1RN基因型L/2+2/2比例和等位基因2比例分别为62.50%和37.50%,明显高于对照组(P<0.05);十二指肠溃疡幽门螺旋杆菌阴性者等位基因2比例为31.82%,明显高于对照组(P<0.05);十二指肠溃疡组、胃溃疡组不同IL-1RN基因型患者治疗痊愈率比较差异无统计学意义(P>0.05)。结论:IL-1RN基因多态性可能与十二指肠溃疡发病有一定的关系,值得进一步研究。
Abstract:
Objective: To investigate the relationship between interleukin -1 receptor antagonist (IL-1RN) gene polymorphism and peptic ulcer. Methods: A total of 180 cases of peptic ulcer in our hospital from January 2016 to January 2018 were selected, including 91 cases of duodenal ulcers (duodenal ulcer group), 89 cases of gastric ulcer (gastric ulcer group), and 270 healthy volunteers as control group. Polymerase chain reaction restriction fragment length polymorphism was used to examine the polymorphism of IL-1RN gene, and rapid urease was used to detect Helicobacter pylori infection. Results:The proportion of IL-1RN genotype L/2+2/2 and the ratio of allele 2 in the duodenal ulcer group were 50.55% and 29.67%, respectively,which were significantly higher than those in the gastric ulcer group and the control group (P<0.05); The proportion of IL-1RN genotype L/2+2/2 and the 2 allele ratio of the Helicobacter pylori positive in the duodenal ulcer group were 50.15% and 29.38%, which were significantly higher than those in the gastric ulcer group and the control group (P < 0.05); The proportion of IL-1RN genotype L/2+2/2 and allele 2 ratio of Helicobacter pylori negative patients in gastric ulcer group were 62.50% and 37.50%, which were significantly higher than those of control group (P< 0.05); The proportion of allele 2 in Helicobacter pylori negative duodenal ulcer was 31.82%, which was significantly higher than that in the control group(P < 0.05);There was no significant difference in the cure rates of IL-1RN genotypes between the duodenal ulcer group and the gastric ulcer group(P>0.05). Conclusion:The polymorphism of IL-1RN gene may be related to the incidence of duodenal ulcer, and is worth further study

参考文献/References:


[1] Wright G P, Davis A T, Koehler T J, et al. Cost-efficiency and outcomes in the treatment of perforated peptic ulcer disease: Laparoscopic versus open approach[J]. Surg, 2014, 156(4):1003
[2] Kim B. Diagnosis and treatment of peptic ulcer disease: present and future perspective[J]. Korean J Gastroentero, 2016, 67(6):318
[3] 刘翔,曾柳苑,林虹.AIF-1及IL-1β在溃疡性结肠炎小鼠体内表达的研究[J].海南医学,2015,26(21):3124
[4] 张雪梅,宋文琦,朱艳丽,等.CYP2C19基因多态性对埃索美拉唑治疗老年消化性溃疡疗效的影响[J].中国现代医生,2016,54(14):1
[5] 邢培祥,杨发林,姜金波,等.IL-1β及IL-1RN intron2基因多态性在中国山东地区汉族人大肠癌中的分布特征[J].中华普通外科杂志,2016,31(5):406
[6] Lanas A, Carrera-Lasfuentes P, García-Rodríguez L A, et al. Outcomes of peptic ulcer bleeding following treatment with proton pump inhibitors in routine clinical practice: 935 patients with high- or low-risk stigmata[J]. Scand J Gastroentero, 2014, 49(10):1181
[7] Prabhu V, Shivani A. An overview of history, pathogenesis and treatment of perforated peptic ulcer disease with evaluation of prognostic scoring in adults[J]. Ann Med Health Sci Res, 2014, 4(1):22
[8] 仵永枫,陈煜.炎症小体的研究进展[J].胃肠病学和肝病学杂志,2015,24(3):360
[9] 段启瑞,邱颐,王彩霞.炎症因子与缺血再灌注损伤研究进展[J].内蒙古医科大学学报,2016,38(2):181
[10] 郑金娟,金丹.NLRP3炎症小体的研究进展[J].延边大学医学学报,2017,40(4):302
[11] 张歆,柯晓,陈锦团,等.IL-1β、IL-4在湿热证溃疡性结肠炎大鼠模型中的动态表达及意义[J].西安交通大学学报(医学版),2015, 36(5):697
[12] 梁翙,丁健民,刘小宇.TNF-α与IL-1β对胃癌腹膜间皮细胞黏附分子mRNA表达的影响[J].胃肠病学和肝病学杂志,2014, 23(3):252
[13] 高永利,叶明,高乐,等.肠黏膜核苷酸结合寡聚化结构域样受体-3炎症小体在肠炎组织中的表达及意义[J].临床和实验医学杂志,2017,16(22):2218
[14] 陈婉珍,张芷嫣,王辉,等.复方铝酸铋颗粒对IL-1β致乙酸胃溃疡复发模型抑制作用的研究[J].河北医药,2017,39(8):1148
[15] 杨松涛.老年十二指肠溃疡根除Hp治疗对胃排空及炎症因子水平的影响[J].河北医学,2016,22(5):711

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备注/Memo

备注/Memo:
作者简介 魏小娟(1984-),主治医师,硕士,研究方向: 消化道肿瘤,E-mail: rzizzks92619@126.com。
更新日期/Last Update: 2019-04-25