|本期目录/Table of Contents|

[1]张 奕,刘长山.呼出气一氧化氮及外周血嗜酸性粒细胞水平在儿童肺炎支原体肺炎中的临床意义[J].天津医科大学学报,2019,25(02):147-149.
 ZHANG Yi,LIU Chang-shan.Clinical significance of FeNO and peripheral blood eosinophil ratio in children with Mycoplasma pneumoniae pneumonia[J].Journal of Tianjin Medical University,2019,25(02):147-149.
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呼出气一氧化氮及外周血嗜酸性粒细胞水平在儿童肺炎支原体肺炎中的临床意义(PDF)
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《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:
25
期数:
2019年02期
页码:
147-149
栏目:
临床医学
出版日期:
2019-03-20

文章信息/Info

Title:
Clinical significance of FeNO and peripheral blood eosinophil ratio in children with Mycoplasma pneumoniae pneumonia
文章编号:
1006-8147(2019)02-0147-03
作者:
张 奕刘长山
(天津医科大学第二医院儿科,天津300211)
Author(s):
ZHANG Yi LIU Chang-shan
(Department of Paediatrics, The Second Hospital, Tianjin Medical University, Tianjin 300211, China)
关键词:
肺炎支原体肺炎嗜酸性粒细胞呼出气一氧化氮肺功能儿童
Keywords:
Mycoplasma pneumoniae pneumonia eosinophil FeNO lung functionchildren
分类号:
R725
DOI:
-
文献标志码:
A
摘要:
目的:探讨呼出气一氧化氮(FeNO)及外周血嗜酸性粒细胞(EOS)水平在儿童肺炎支原体肺炎(MPP)中的临床意义。方法:选择2015年4月-2017年4月因肺炎住院治疗患儿共242例,根据肺炎支原体(MP)抗体水平分为MPP组(142例)及非MPP组(100例),比较各组间FeNO、EOS、血清总IgE(TIgE)水平、肺功能及临床特点。结果:MPP组较非MPP组FeNO及EOS比例升高,但TIgE水平无统计学差异,肺功能中呼气峰流速值(PEF)、用力呼气流量50%及75%(MEF50,MEF75)占预计值百分比降低。MPP组影像学表现肺部实变影较多,易出现胸腔积液,肺功能受损及影像学改变与外周血EOS水平相关。结论:儿童MPP可出现FeNO水平及外周血EOS比例增高,外周血EOS水平可能影响MP感染后肺功能及影像学临床表现。
Abstract:
Objective: To investigate clinical significance of Fractional exhaled nitric oxide (FeNO) and peripheral blood eosinophils (EOS) levels in children with Mycoplasma pneumoniae pneumonia (MPP). Methods: Two hundred and forty-two cases of hospitalized children with pneumonia from April 2015 to April 2017 were included and divided into MPP group (142 cases) and non-MPP group (100 cases) according to the antibody level of Mycoplasma pneumoniae (MP), and FeNO, EOS, serum total IgE (TIgE) level, lung function. Clinical characteristics in each group were compared. Results: Compared with the non-MPP group, FeNO and EOS of the MPP group was increased, but no difference was found in TIgE, and lung function was reduced. MPP group was prone to lobar consolidation and pleural effusion. Impaired lung function and imaging changes were associated with peripheral blood EOS levels. Conclusion: EOS and FeNO level may increase in children with MPP. The peripheral blood EOS ratio may affect lung function and imaging findings after MP infection.

参考文献/References:


[1] Youn Y S, Lee K Y. Mycoplasma pneumoniae pneumonia in children[J].Korean J Pediatr, 2012,55(2):42
[2] Fan Q, Gu T, Li P, et al. Roles of T-cell Immunoglobulin and Mucin Domain Genes and Toll-like Receptors in Wheezy Children with Mycoplasma pneumoniae Pneumonia [J] . Heart Lung Circ, 2016,25(12):1226
[3] 中华医学会儿科学分会呼吸学组,《中华儿科杂志》编辑委员会.儿童社区获得性肺炎管理指南(2013年修订) [J].中华儿科杂志,2013,51(10):745
[4] Zhi Y O, Rong Z, Feng H W, et al. Retrospective analysis of mycoplasma pneumoniae infection in pediatric fatal pneumonia in guangzhou[J].Clin Pediatr, 2008,47(8):791
[5] Harjacek M,Ostojic J, Djakovic R, et al. Juvenile spondyloarthropathies associated with Mycoplasma pneumoniae infection[J]. Clin Rheumatol,2006,25(4):470
[6] Christie L J, Honarmand S, Talkington D F, et al. Pediatric encephalitis: what is the role of Mycoplasma pneumoniae[J].Pediatrics,2007,120(2):305
[7] 陈广道,梁少媛,冯柏潮.儿童支原体肺炎的临床表现和实验室检查及影像学特点分析[J].中国全科医学,2015,18(1):59
[8] 赵德育,陈慧中,郑跃杰,等. 肺炎支原体感染的诊断[J].中华儿科杂志,2016,54(2):98
[9] 王鑫,马春艳,张亚京,等. 肺炎支原体肺炎患J LCb周血 Th1/T1=12表达及肺功能变化的临床意义[J].中华临床杂志(电子版),2014,8(6):1031
[10] 孙红,孙红妹. 肺炎支原体直接损伤及其免疫学致病机制研究进展[J].中华微生物和免疫学杂志, 2015,35(1):65
[11] 张晗,尚云晓,周潇男,等. 肺炎支原体感染在BALB/c小鼠肺组织不同时间炎症的变化[J]. 解剖学研究, 2012,34(1):8
[12] Joo H K, Tae Shik C, Jin Hwa M, et al. Serial Changes in Serum Eosinophil-associated Mediators between Atopic and Non-atopic Children after Mycoplasma pneumoniae pneumonia[J]. Allergy Asthma Immunol Res,2014,6(5):428
[13] 白晓雪,华树成,竭晶,等. 呼出气一氧化氮在慢性过敏性肺炎诊断中的应用价值[J]. 中国实验诊断学,2014,18(1):39
[14] 白翠芬. 呼出气一氧化氮检测对儿童肺炎支原体感染的临床价值分析[J].白求恩医学杂志,2016,14(2):151
[15] Reddel H K,Taylor D R, Bateman E D, et al. An official American thoracic society/European respiratory society statement: asthma control and exacerbations standardizing endpoints for clinical asthma trails and clinical practice[J]. Am J Respir Crit Care Med,2009, 180(1): 59
[16] Ozdemir C, Akdis M, Akdis C A. T regulatory cells and their counterparts: masters of immune regulation[J]. Clin Exp Allergy,2009, 39(5):626
[17] 乔凌燕,孙广荣,马少春. 支原体感染后慢性咳嗽病儿FeNO水平及意义[J].齐鲁医学杂志,2015,30(6):695
[18] Alcoba G, Keitel K, Maspoli V,et al. A three-step diagnosis of pediatric pneumonia at the emergency department using clinical predictors, C-reactive protein, and pneumococcal PCR[J]. Eur J Pediatr, 2017, 176(6):815

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备注/Memo

备注/Memo:
基金项目 天津医科大学科学基金(2014KYQ25) 作者简介 张奕(1983-)女,主治医师,硕士,研究方向:儿科;E-mail: kyzz3347@163.com。
更新日期/Last Update: 2019-04-25