|本期目录/Table of Contents|

[1]聂红艳,邱艳丽,靳 燕,等.TIAM1蛋白在神经母细胞瘤中的表达及临床意义[J].天津医科大学学报,2019,25(02):143-146.
 NIE Hong-yan,QIU Yan-li,JIN Yan,et al.Expression and Clinical Significance of TIAM1 in Neuroblastoma[J].Journal of Tianjin Medical University,2019,25(02):143-146.
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TIAM1蛋白在神经母细胞瘤中的表达及临床意义(PDF)
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《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:
25
期数:
2019年02期
页码:
143-146
栏目:
临床医学
出版日期:
2019-03-20

文章信息/Info

Title:
Expression and Clinical Significance of TIAM1 in Neuroblastoma
文章编号:
1006-8147(2019)02-0143-04
作者:
聂红艳邱艳丽靳 燕曹嫣娜闫 杰李 杰王景福赵 强
(天津医科大学肿瘤医院儿童肿瘤科,国家肿瘤临床医学研究中心,天津市“肿瘤防治”重点实验室,天津市恶性肿瘤临床医学研究中心,天津300060)
Author(s):
NIE Hong-yan QIU Yan-li JIN Yan CAO Yan-na YAN Jie LI Jie WANG Jing-fu ZHAO Qiang
(Department of Pediatric Oncology, Cancer Institute and Hospital, Tianjin Medical University, National Clinical Research Center for Cancer, Tianjin Key Laboratory of Cancer Prevention and Therapy, Tianjin 300060, China)
关键词:
TIAM1神经母细胞瘤分化
Keywords:
TIAM1neuroblastomadifferentiation
分类号:
R739.4
DOI:
-
文献标志码:
A
摘要:
目的:探索T淋巴瘤侵袭转移1蛋白(TIAM1)在神经母细胞瘤(NB)中的表达及临床意义。方法:运用免疫组化法检测61例神经母细胞瘤组织中TIAM1蛋白的表达,并分析其与NB患者临床病理特征及预后之间的关系。结果:TIAM1主要定位于细胞浆中,但也可表达在细胞核内,其表达与NB分化程度相关(χ2=4.493,P=0.034),分化程度越高,表达越强;但其表达与年龄,INSS分期,肿瘤部位等无关。结论:TIAM1的表达与NB的分化程度呈正相关,有望成为NB潜在治疗靶点。
Abstract:
Objective: To explore the expression and clinical significance of TIAM1(T-lymphoma invasion and metastasis 1) in the neuroblastoma. Methods:The expression of TIAM1 protein in 61neuroblastoma tissues was detected by immunohistochemical method and its correlation with the clinicopathological characteristics and prognosis was analyzed. Results: TIAM1, mainly located in the cytoplasm, could also be expressed in the nucleus. Its expression was related to the degree of differentiation of NB(χ2=6.205,P=0.013)the higher the differentiation degree, the stronger the expression. However, the expression was not related to age, INSS stage, tumor location and other factors. Conclusion: There is a positive correlation between the expression of TIAM1 and the differentiation of NB,which is expected to be a potential target for NB treatment.

参考文献/References:


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备注/Memo

备注/Memo:
作者简介 聂红艳(1990-),女,硕士在读,研究方向:儿童肿瘤基础与临床;通信作者:赵强,E-mail: qiangzhao169@sina.com。
更新日期/Last Update: 2019-04-25