|本期目录/Table of Contents|

[1]聂红艳,邱艳丽,靳 燕,等.TIAM1蛋白在神经母细胞瘤中的表达及临床意义[J].天津医科大学学报,2019,25(02):143-146.
 NIE Hong-yan,QIU Yan-li,JIN Yan,et al.Expression and Clinical Significance of TIAM1 in Neuroblastoma[J].Journal of Tianjin Medical University,2019,25(02):143-146.





Expression and Clinical Significance of TIAM1 in Neuroblastoma
聂红艳邱艳丽靳 燕曹嫣娜闫 杰李 杰王景福赵 强
NIE Hong-yan QIU Yan-li JIN Yan CAO Yan-na YAN Jie LI Jie WANG Jing-fu ZHAO Qiang
(Department of Pediatric Oncology, Cancer Institute and Hospital, Tianjin Medical University, National Clinical Research Center for Cancer, Tianjin Key Laboratory of Cancer Prevention and Therapy, Tianjin 300060, China)
Objective: To explore the expression and clinical significance of TIAM1(T-lymphoma invasion and metastasis 1) in the neuroblastoma. Methods:The expression of TIAM1 protein in 61neuroblastoma tissues was detected by immunohistochemical method and its correlation with the clinicopathological characteristics and prognosis was analyzed. Results: TIAM1, mainly located in the cytoplasm, could also be expressed in the nucleus. Its expression was related to the degree of differentiation of NB(χ2=6.205,P=0.013)the higher the differentiation degree, the stronger the expression. However, the expression was not related to age, INSS stage, tumor location and other factors. Conclusion: There is a positive correlation between the expression of TIAM1 and the differentiation of NB,which is expected to be a potential target for NB treatment.


[1] Boissier P, Huynh-Do U. The guanine nucleotide exchange factor Tiam1: a Janus-faced molecule in cellular signaling[J]. Cell Signal, 2014, 26(3): 483
[2] Wu Q Y, Wang Y, Tong J C, et al. Expression and clinical significance of Tiam1 gene in esophageal carcinoma[J]. Int J Clin Exp Med, 2015, 8(11): 21229
[3] Chen G, Lu L, Liu C, et al. MicroRNA-377 suppresses cell proliferation and invasion by inhibiting TIAM1 expression in hepatocellular carcinoma[J]. PLoS One, 2015, 10(3): e0117714
[4] Yang Y, Wu Q, Li N, et al. Upregulation of Tiam1 contributes to cervical cancer disease progression and indicates poor survival outcome[J]. Hum Pathol, 2018,75:179
[5] Liu L, Wu B, Cai H, et al. Tiam1 promotes thyroid carcinoma metastasis by modulating EMT via Wnt/beta-catenin signaling[J]. Exp Cell Res, 2018, 362(2): 532
[6] Diamantopoulou Z, White G, Fadlullah M Z H, et al. TIAM1 Antagonizes TAZ/YAP Both in the Destruction Complex in the Cytoplasm and in the Nucleus to Inhibit Invasion of Intestinal Epithelial Cells[J]. Cancer Cell, 2017, 31(5): 621
[7] Sanmartin E, Yanez Y, Fornes-Ferrer V, et al. TIAM1 variants improve clinical outcome in neuroblastoma[J]. Oncotarget, 2017, 8(28): 45286
[8] Cao Y N, Jin Y, Yu J P, et al. Clinical evaluation of integrated panel testing by next-generation sequencing for somatic mutations in neuroblastomas with MYCN unamplification[J]. Oncotarget, 2017, 8(30): 49689
[9] Matthay K K, Maris J M, Schleiermacher G, et al. Neuroblastoma[J]. Nat Rev Dis Primers, 2016, 2: 16078
[10] Bosse K R, Maris J M. Advances in the translational genomics of neuroblastoma: From improving risk stratification and revealing novel biology to identifying actionable genomic alterations[J]. Cancer, 2015, 122(1): 20
[11] Aygun N. Biological and Genetic Features of Neuroblastoma and Their Clinical Importance[J]. Curr Pediatr Rev, 2018,14(2):73
[12] Romain C, Paul P, Kim K W, et al. Targeting Aurora kinase-A downregulates cell proliferation and angiogenesis in neuroblastoma[J]. J Pediatr Surg, 2013, 49(1): 159
[13] Brockmann M, Poon E, Berry T, et al. Small Molecule Inhibitors of Aurora-A Induce Proteasomal Degradation of N-Myc in Childhood Neuroblastoma[J]. Cancer Cell, 2016, 30(2): 357
[14] Ham J, Costa C, Sano R, et al. Exploitation of the Apoptosis-Primed State of MYCN-Amplified Neuroblastoma to Develop a Potent and Specific Targeted Therapy Combination[J]. Cancer Cell, 2016, 29(2): 159
[15] Infarinato N R, Park J H, Krytska K, et al. The ALK/ROS1 Inhibitor PF-06463922 Overcomes Primary Resistance to Crizotinib in ALK-Driven Neuroblastoma[J]. Cancer Discov, 2016, 6(1): 96
[16] Mosse Y P, Laudenslager M, Longo L, et al. Identification of ALK as a major familial neuroblastoma predisposition gene[J]. Nature, 2008, 455(7215): 930
[17] Demarco R S, Struckhoff E C, Lundquist E A. The Rac GTP exchange factor TIAM-1 acts with CDC-42 and the guidance receptor UNC-40/DCC in neuronal protrusion and axon guidance[J]. PLoS Genet, 2012, 8(4): e1002665
[18] Leeuwen F N, Kain H E, Kammen R A, et al. The guanine nucleotide exchange factor Tiam1 affects neuronal morphology; opposing roles for the small GTPases Rac and Rho[J]. J Cell Biol, 1997, 139(3): 797
[19] Ellenbroek S I, Iden S, Collard J G. The Rac activator Tiam1 is required for polarized protrusional outgrowth of primary astrocytes by affecting the organization of the microtubule network[J]. Small GTPases, 2012, 3(1): 4
[20] Pasten C, Cerda J, Jausoro I, et al. ApoER2 and Reelin are expressed in regenerating peripheral nerve and regulate Schwann cell migration by activating the Rac1 GEF protein, Tiam1[J]. Mol Cell Neurosci, 2015, 69: 1
[21] Cajanek L, Ganji R S, Henriques-Oliveira C, et al. Tiam1 regulates the Wnt/Dvl/Rac1 signaling pathway and the differentiation of midbrain dopaminergic neurons[J]. Mol Cell Biol, 2013, 33(1): 59
[22] Speleman F, Park J R, Henderson T O. Neuroblastoma: A Tough Nut to Crack[J]. Am Soc Clin Oncol Educ Book, 2016, 35: e548
[23] Brodeur G M, Bagatell R. Mechanisms of neuroblastoma regression[J]. Nat Rev Clin Oncol, 2014, 11(12): 704
[24] Diede S J. Spontaneous regression of metastatic cancer: learning from neuroblastoma[J]. Nat Rev Cancer, 2014, 14(2): 71
[25] Kitanaka C, Kato K, Ijiri R, et al. Increased Ras expression and caspase-independent neuroblastoma cell death: possible mechanism of spontaneous neuroblastoma regression[J]. J Natl Cancer Inst, 2002, 94(5): 358
[26] Shirazi Fard S, Kele J, Vilar M, et al. Tiam1 as a signaling mediator of nerve growth factor-dependent neurite outgrowth[J]. PLoS One, 2010, 5(3): e9647.
[27] Yamauchi J, Miyamoto Y, Tanoue A, et al. Ras activation of a Rac1 exchange factor, Tiam1, mediates neurotrophin-3-induced Schwann cell migration[J]. Proc Natl Acad Sci U S A, 2005, 102(41): 14889




作者简介 聂红艳(1990-),女,硕士在读,研究方向:儿童肿瘤基础与临床;通信作者:赵强,E-mail: qiangzhao169@sina.com。
更新日期/Last Update: 2019-04-25