|本期目录/Table of Contents|

[1]余 冬,冯 霜,李 俊,等.MiR-199a-3p在胰腺癌中的表达水平及生物信息学分析[J].天津医科大学学报,2019,25(02):119-123.
 YU Dong,FENG Shuang,LI Jun,et al.The expression of miR-199a-3p in pancreatic cancer and bioinformatics analysis[J].Journal of Tianjin Medical University,2019,25(02):119-123.





The expression of miR-199a-3p in pancreatic cancer and bioinformatics analysis
余 冬冯 霜李 俊孙晋津
(天津医科大学第二医院肝胆胰外科,天津 300211)
YU DongFENG ShuangLI JunSUN Jin-jin
(Department of Hepatobiliary and pancreatic surgery Surgery, The Second Hospital,Tianjin Medical University,Tianjin 300211,China)
miR-199a-3p pancreatic cancer Bioinformatics
Objective: To investigate miR-199a-3p’s expression levels and diagnostic value in pancreatic cancer, and to conduct bioinformatics analysis. Methods:We gathered miR-199a-3p expression data of pancreatic cancer and normal pancreatic tissues by analysis of a public dataset from Gene Expression Omnibus (GEO) databases. We plotted ROC curve and conducted Meta-analysis using all collected data. Furthermore, the bioinformatics analysis of miR-199a-3p involved target prediction analysis, gene ontology enrichment and KEGG pathway enrichment. Results: A total of six GEO data were finally collected in this study, four of these data showed significant diagnostic value by conducting ROC curve,and Meta-analysis indicated that miR-199a-3p expression was significantly higher in pancreatic cancer by GEO data compared with normal pancreatic tissue (P<0.001). The 221 target genes were predicted as potential target genes for miR-199a-3p. The function of target genes was mostly enriched in the regulation of cell metabolism, regulation of gene expression, protein domain specific binding and other biological processes(P<0.001). KEGG analysis was mostly observed in enrichment pathway, such as PI3K-Akt signaling pathway, focal adhesion, actin cytoskeleton regulation, cancer pathway, Hippo signaling pathway, sphingolipid signaling pathways, ErbB signaling pathway, MAPK signaling pathway and other Signal pathways (P<0.05). Conclusion: MiR-199a-3p expression is significantly higher in pancreatic cancer compared with normal pancreatic tissues. It can be used as a potential diagnostic biomarker of pancreatic cancer, and it may play a vital role in the development of pancreatic cancer. Meanwhile, it could provide a research direction for the treatment of pancreatic cancer in the future.


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作者简介 余冬(1993-),男,硕士在读,研究方向:普通外科;通信作者:孙晋津,E-mail:sun.jinjin@126.com。
更新日期/Last Update: 2019-04-25