|本期目录/Table of Contents|

[1]蔡 晗,刘 刚,陈 欣.老年高血压患者血管弹性和红细胞携氧能力与其心肺功能和生活质量关系[J].天津医科大学学报,2017,23(05):437-441.
 CAI Han,LIU Gang,CHEN Xin.Relationship between vessel elasticity,erythrocyte oxygen carrying capacity and heart/lung function and quality of life in elderly patients with hypertension[J].Journal of Tianjin Medical University,2017,23(05):437-441.
点击复制

老年高血压患者血管弹性和红细胞携氧能力与其心肺功能和生活质量关系(PDF)
分享到:

《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:
23
期数:
2017年05期
页码:
437-441
栏目:
临床医学
出版日期:
2017-09-20

文章信息/Info

Title:
Relationship between vessel elasticity,erythrocyte oxygen carrying capacity and heart/lung function and quality of life in elderly patients with hypertension
文章编号:
1006-8147(2017)05-0437-05
作者:
蔡 晗12刘 刚3陈 欣4
(1.天津医科大学研究生院,天津 300070;2.天津市胸科医院人事科, 天津 300222; 3.中国人民解放军陆军总医院麻醉科,北京 100700; 4.天津医科大学公共卫生学院数学教研室,天津 300070)
Author(s):
CAI Han12LIU Gang3CHEN Xin4
(1. Graduate School,Tianjin Medical University,Tianjin 300070 China; 2.Personnel secyion,?Tianjin Chest Hospital,Tianjin 300222, China;3.Department of Anesthesiology,Chinese PLA Army General Hospital,Beijing 100700 , China; 4.Department of Mathematics,School of Public Health,Tianjin Medical University,Tianjin 300070, China)
关键词:

老年高血压血管弹性红细胞携氧能力心肺功能生活质量

Keywords:
hypertension vascular elasticity erythrocyte oxygen carrying capacity heart and lung function quality of life

分类号:
R544.1+ R592
DOI:
-
文献标志码:
A
摘要:

目的:探讨老年高血压患者的血管弹性和红细胞携氧量与其心肺功能和生活质量的关系。方法:随机选择100名老年受试者分为两组:观察组为老年高血压患者(50例);对照组为相对健康的老年人(50例)。对比两组:(1)血管弹性指标:大动脉和小动脉的弹性指数、动脉血管顺应性、血管僵硬度以及血管壁厚度;(2)红细胞血氧能力指标:测定血氧饱和度50%时的氧分压(P50),用ELISA检测患者红细胞内2,3-二磷酯甘油酸(2,3-DPG)及丙酮酸激酶(PK)含量;(3)心脏功能检测:主动脉直径、左房内径、左室舒张内径、右房内径、右室内经、肺动脉内径、左室射血分数、室间隔厚度、左室后壁厚度及左室前壁厚度;(4)静态肺功能检测:潮气量、每分钟通气量、肺活量、最大通气量、第1秒用力呼气量、第1秒率及深吸气量;(5)采用生存质量核心问卷(QLQ-C30)对患者进行生存质量评估。对检测结果进行统计学分析。结果:对照组大、小动脉弹性指数均明显高于观察组(P<0.05);对照组血管顺应性明显高于观察组(P<0.05);而观察组血管僵硬度则明显高于对照组(P<0.05);观察组动脉内膜中层厚度大于对照组(P<0.05);观察组动脉脉搏波速高于对照组(P<0.05)。观察组外周血P50高于对照组(P<0.05);观察组外周血2,3-DPG和PK含量均高于对照组(P<0.05)。对照组主要心肺功能指标均优于观察组(P<0.05);观察组在躯体、角色、认知、情绪、社会等方面功能和整体生活质量各项指标评分均明显低于对照组(P<0.05)。结论:老年高血压患者动脉血管弹性降低、红细胞携氧能力下降,由此会进一步造成患者心肺功能的下降和生活质量的降低。

Abstract:
Objective To detect the relationship between vessel elasticity,erythrocyte oxygen carrying capacity and heart/lung function and quality of life. Methods A hundred subjects were randomly selected and divided into two groups: Observer group of elderly patients with hypertension (n=50); control group of normal aged person (n=50). Comparing two groups :(1)Blood vessel elasticity indexes: Elastic index aorta and small arteries, arterial vascular compliance, vascular stiffness and vascular wall thickness;(2)RBC oxygen capacity indexes: Determination of oxygen saturation of 50% oxygen partial pressure (P50), enzyme-linked immunosorbent assay patient RBC 2,3-glycerol phosphate ester acid (2,3-DPG) and pyruvate kinase (PK) content;(3)Color Doppler heart function tests;(4)Static pulmonary function testing;(5) The core quality of life questionnaire (QLQ-C30) was usedto assess the quality of life for patients. Test results were statistically analyzed. Results Large and small artery elasticity indexes of the control group were significantly higher than those in the observation group (P<0.05); the control group was significantly higher than that observed in vascular compliance group (P<0.05); and vascular stiffness in the observation group was significantly higher (P<0.05); arterial intima-media thickness of the observation group was larger than the control group (P<0.05); arterial pulse wave velocity was higher than the old observation group (P<0.05). Peripheral blood of patients in the observation group which was lower than the control group reached P50 (P<0.05); the observation group with 2,3-DPG content and PK were higher (P<0.05). The main indicators of heart and lung function of the observation group were better than the control group (P<0.05); the observation group were superior in physical, role, cognitive, emotional, and social function and the overall quality of life was significantly lower than the control group (P<0.05). ConclusionFor elderly hypertensive patients, their arterial elasticity and erythrocyte oxygen carrying capacity would decline, which will further make their heart and lung function and quality of life decreased.

参考文献/References:

[1] Modery-Pawlowski C L, Tian L L, Pan V, et al. Synthetic approaches to RBC mimicry and oxygen carrier systems[J]. Biomacromol, 2013, 14(4): 939

[2] Sun N, Xi Y, Zhu Z, et al. Effects of Anxiety and Depression on Arterial Elasticity of Subjects With Suboptimal Physical Health[J]. Clin Cardiol, 2015, 38(10): 614

[3] Kinlay S, Creager M A, Fukumoto M, et al. Endothelium-derived nitric oxide regulates arterial elasticity in human arteries in vivo[J]. Hypertension, 2001,38(5):1049

[4] Fjeldstad A S, Fjeldstad C, Acree L S, et al. The relationship between arterial elasticity and metabolic syndrome features[J]. Angiology, 2007,58(1):5

[5] Zhang Y, Zhou Z, Gao J, et al. Health-related quality of life and its influencing factors for patients with hypertension: evidence from the urban and rural areas of Shaanxi Province, China[J]. BMC Health Serv Res, 2016,16(1):277

[6] 王文. 中国高血压基层管理指南 (2014年修订版)[J]. 中华高血压杂志, 2015, 23(1): 24

[7] Hickey K T, Hauser N R, Valente L E, et al. A single-center randomized, controlled trial investigating the efficacy of a mHealth ECG technology intervention to improve the detection of atrial fibrillation: the iHEART study protocol[J]. BMC Cardiovasc Disord, 2016,16:152

[8] Bajorek B, Lemay K S, Magin P, et al. Implementation and evaluation of a pharmacist-led hypertension management service in primary care: outcomes and methodological challenges[J]. Pharm Pract (Granada), 2016,14(2):723

[9] Schiffrin E L, Campbell N R, Feldman R D, et al. Hypertension in Canada: Past, Present, and Future[J]. Ann Glob Health, 2016,82(2):288

[10] Jo H E, Corte T J, Wort S J, et al. Year in review 2015:Interstitial lung disease, pulmonary vascular disease, pulmonary function, sleep and ventilation, cystic fibrosis and paediatric lung disease[J]. Respirology, 2016,21(3):556

[11] Maher T M, Piper A, Song Y, et al. Year in review 2014: Interstitial lung disease, physiology, sleep and ventilation, acute respiratory distress syndrome, cystic fibrosis, bronchiectasis and rare lung disease[J]. Respirology, 2015, 20(5): 834

[12] Wirth A, Wang S, Takefuji M, et al. Age-dependent blood pressure elevation is due to increased vascular smooth muscle tone mediated by G-protein signalling[J]. Cardiovasc Res, 2016,109(1):131

[13] Potoka K P, Gladwin M T. Vasculopathy and pulmonary hypertension in sickle cell disease[J]. Am J Physiol Lung Cell Mol Physiol, 2015 ,308(4): 314

[14] St?pniewska J, Go?embiewska E, Do??gowska B, , et al. Oxidative stress and antioxidative enzyme activities in chronic kidney disease and different types of renal replacement therapy[J]. Curr Protein Pept Sci, 2015,16(3):243

[15] Van Hemelrijck J, Levien L J, Veeckman L , et al. A safety and efficacy evaluation of hemoglobin-based oxygen carrier HBOC-201 in a randomized, multicenter red blood cell controlled trial in noncardiac surgery patients[J]. Anesth Analg, 2014 ,119(4):766

[16] Naeije R, Dedobbeleer C. Pulmonary hypertension and the right ventricle in hypoxia[J]. Exp Physiol, 2013,98(8):1247

[17] Tan Q, Kerestes H, Percy M J, et al. Erythrocytosis and pulmonary hypertension in a mouse model of human HIF2A gain of function mutation[J]. J Biol Chem, 2013, 288(24):17134

[18] Risbano M G, Kanias T, Triulzi D, et al. Effects of aged stored autologous red blood cells on human endothelial function[J]. Am J Respir Crit Care Med, 2015,192(10):1223

?

相似文献/References:

备注/Memo

备注/Memo:
作者简介 蔡晗(1988-),女,硕士在读,研究方向:社会医学与卫生事业管理;通信作者:陈欣,E-mail:tjmuhr@tmu.edu.cn
更新日期/Last Update: 2017-09-20