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《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:

23卷

期数:

2017年01期

页码:

38-40

栏目:

临床医学

出版日期:

2017-01-16

文章信息/Info

Title:

Value of early postoperative ¹⁸F-FDG PET/CT in restaging of the colorectal carcinoma

文章编号:

1006-8147（2017）01-0038-03

作者:

付 蔷; 徐文贵; 于筱舟; 刘建井; 李小凤

(天津医科大学肿瘤医院分子影像与核医学诊疗科,国家肿瘤临床医学研究中心;天津市“肿瘤防治”重点实验室;天津市恶性肿瘤临床医学研究中心,天津 300060)

Author(s):

FU Qiang;  XU Wen-gui;  YU Xiao-zhou; LIU Jian-jing; LI Xiao-feng

(Department of Molecular Imaging and Nuclear Medicine, Cancer Institute and Hospital, Tianjin Medical University , National Clinical Research Center for Cancer, Tianjin Key Laboratory of Cancer Prevention and Therapy ,Tianjins Clinical Research Center for China, Tianjin 300060, China)

关键词:

结直肠癌; ¹⁸F-FDG PET/CT显像; 再分期

Keywords:

colorectal carcinoma; 18F-FDG PET/CT;  restage

分类号:

R735.3

DOI:

-

文献标志码:

A

摘要:

目的：评价术后早期¹⁸F-FDG PET/CT显像在结直肠癌再分期中的临床价值。方法：回顾性分析术前分期明确后于本院行局部结直肠癌切除手术，并且行术后¹⁸F-FDG PET/CT显像的结直肠癌患者46例，根据显像结果对其进行再分期，分析分期改变率，并通过χ²检验和秩和检验分析再分期影响因素。结果：46例患者中共14例（30.4％）出现病理性¹⁸F-FDG 的摄取，其中13例证实为恶性病灶且分期上升，肝脏转移7例（53.8％），外周淋巴结转移5例（38.5％），腹膜转移1例（7.7％），意外发现其他类型肿瘤2例（15.4％），1例证实为淋巴结炎性反应性增生。PET/CT在诊断结直肠癌远处转移方面的灵敏度为100％，特异度为97.3％，阳性预测率为92.9％，阴性预测率为100％。秩和检验结果表明，相对于较早期I/II期结直肠癌病人而言，术后早期¹⁸F-FDG PET/CT显像对于晚期III期结直肠癌病人再分期改变率较高，χ²检验结果显示年龄、性别、原发部位对于术后再分期无显著影响。结论：术后早期¹⁸F-FDG PET/CT显像在结直肠癌再分期中具有重要的临床价值，尤其是对于晚期III期病人意义更为明显。

Abstract:

Objective: To evaluate ¹⁸F-FDG PET/CT in the diagnosis of restaging for colorectal carcinoma. Methods: Forty six cases, from Tumor Hospital of Tianjin Medical University, of postoperative colorectal carcinoma examined by ¹⁸F-FDG PET/CT imaging were reviewed to restage and analyze the influence factors by Chi-squared test and Kruskal-Wallis Test. Results: In all cases, pathological ¹⁸F-FDG uptake was observed in 14(30.4%). Of these,13 were upstaged with true-positive metastatic disease in distant organs after further workup liver in 7 cases, lymph node in 5 cases, peritoneum in one case) and one case had false-positive finding. The sensitivity and specificity of PET/CT for detecting metastatic disease were 100% and 97.3%, the positive predictive value was 92.9% and the negative predictive value was 100%.The Kruskal-Wallis univariate analysis showed that patients in stage III had more risk than the patients in stage I/II (P ＜0.05). The Chi-square test showed that age, sex and tumor location were not significantly associated with upstaging. Conclusion: The early postoperative ¹⁸F-FDG PET/CT have an important role in restaging of the colorectal carcinoma especially in the patients in stage III.

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备注/Memo

备注/Memo:

作者简介 付蔷（1991-），女，硕士在读，研究方向：肿瘤影像与核医学诊断；通信作者：徐文贵，E-mail： wenguixy@126.com。

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更新日期/Last Update: 2017-01-16