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[1]朱晓颖,王 燕,闫 欢,等.小剂量红霉素对肺间质纤维化血清TGF-β、IL-13的影响[J].天津医科大学学报,2015,21(01):55-58.
 ZHU Xiao-ying,WANG Yan,YAN Huan,et al.Effect of small-dose erythromycin on serum TGF-β and IL-13 in patients with idiopathic pulmonary fibrosis[J].Journal of Tianjin Medical University,2015,21(01):55-58.
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《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:
21卷
期数:
2015年01期
页码:
55-58
栏目:
临床医学
出版日期:
2015-01-20

文章信息/Info

Title:
Effect of small-dose erythromycin on serum TGF-β and IL-13 in patients with  idiopathic pulmonary fibrosis
文章编号:
1006-8147(2015)0-0055-04
作者:
朱晓颖1王 燕2闫 欢3郭美南4胡志东3
(1.天津医科大学研究生院,天津300070;2.天津医科大学总医院肿瘤科,天津300052;3.天津医科大学总医院免疫室,天津300052;4.天津医科大学总医院呼吸科,天津300052)
Author(s):
ZHU Xiao-ying1WANG Yan2YAN Huan3GUO Mei-nan4HU Zhi-dong3
(1.Graduate School,Tianjin Medical University,Tianjin 300070,China;2.Department of Oncology,General Hospital,Tianjin Medical University,Tianjin 300052,China;3.Laboratory of Immunology,General Hospital,Tianjin Medical University,Tianjin 300052,China;4.Department of Respiratory,General Hospital,Tianjin Medical University,Tianjin 300052 ,China)
关键词:
特发性肺间质纤维化转化生长因β白介素13 红霉素
Keywords:
 idiopathic pulmonary fibrosistransforming growth factor-β IL-13erythromycin
分类号:
R563
DOI:
-
文献标志码:
A
摘要:
目的:探讨小剂量红霉素对特发性肺间质纤维化血清转化生长因β(TGF-β)、白介素13(IL-13)的影响。方法:将39例特发性肺纤维化患者随机分为常规治疗组(A组)和小剂量红霉素治疗组(B组),采用双抗体夹心ABC-ELISA法对肺间质纤维化两组及健康对照组(C组)血清TGF-β、IL-13进行测定。结果:A、B两组血清TGF-β及IL-13水平均明显高于C组(P <0.05, P<0.05)。治疗后B组动脉血氧饱和度(SaO2 )明显高于A组,差异有显著性(P<0.05);B组血清TGF-β、IL-13水平均低于A组,但差异无显著性(P>0.05)。血清TGF-β、IL-13水平与血氧分压、血氧饱和度、肺泡-动脉氧分压差(AaDO2 )无直线相关关系。结论:细胞因子的紊乱与特发性肺间质纤维化有密切关系,红霉素可影响特发性肺间质纤维化的炎症反应,改善缺氧。
Abstract:
Objective: To investigate the effect of small-dose erythromycin on serum TGF-β and IL-13 in patients with idiopathic pulmonary fibrosis. Methods: Thirty-nine patients with idiopathic pulmonary fibrosis were randomly divided into two groups, conventional glucocorticoid treatment was used in 20 cases (Group A) and small-dose erythromycin was administrated in another 19 cases (Group B). Serum transforming growth factor-β (TGF-β) and interleukin-13 (IL-13) were detected in group A and B and healthy controls (Group C) by double antibody sandwich ABC-ELISA. Results: Serum TGF-β and IL-13 levels of both group A and group B were significantly higher than those of control (P<0.001, P<0.05, respectively). The average level of SaO2 in Group B was significantly higher than that in Group A after treatment of small-dose erythromycin. No linear correlation was found between serum level of TGF-β and IL-13 and PO2, SaO2, and AaDO2. Conclusion: Disorder of cytokines is associated with idiopathic pulmonary fibrosis, and small-dose erythromycin treatment could mitigate inflammation in idiopathic pulmonary fibrosis.

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相似文献/References:

[1]朱晓颖,王 燕,闫 欢,等.小剂量红霉素对肺间质纤维化血清TGF-β、IL-13的影响[J].天津医科大学学报,2015,21(03):55.
 ZHU Xiao-ying,WANG Yan,YAN Huan,et al.Effect of small-dose erythromycin on serum TGF-β and IL-13 in patients with idiopathic pulmonary fibrosis[J].Journal of Tianjin Medical University,2015,21(01):55.

备注/Memo

备注/Memo:

 基金项目 天津医科大学科研基金资助项目(2003KY63)

作者简介 朱晓颖,(1981- ),女,硕士在读,研究方向:呼吸系统疾病;通信作者:王燕,E-mail:wangyan5701@sohu.com.。

更新日期/Last Update: 2015-06-11